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A1SAE2

- FTHS_SHEAM

UniProt

A1SAE2 - FTHS_SHEAM

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Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Shewanella amazonensis (strain ATCC BAA-1098 / SB2B)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi62 – 698ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSAMA326297:GH0T-3266-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:Sama_3146
OrganismiShewanella amazonensis (strain ATCC BAA-1098 / SB2B)
Taxonomic identifieri326297 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
ProteomesiUP000009175: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 560560Formate--tetrahydrofolate ligasePRO_0000293058Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi326297.Sama_3146.

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiLKHHGGV.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1SAE2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLTDMEISRQ ANVRPIGWIA DDFGLGKHLW REAGHAMAKI SLEAARAPLR
60 70 80 90 100
GKLVIVTAVT PTPHGEGKTV TTIGLTQGLH LLGHKACACI RQPSLGPVFG
110 120 130 140 150
VKGGAAGGGY AQVVPMEVMN LHMTGDIHAV TSAHNLAAAA IDARLFHETR
160 170 180 190 200
LGCESFSAKT GLPALNIDPE RILWRRVVDH NDRSLRQIEL GLGDNNGPVH
210 220 230 240 250
GGGFDITAAS ELMAILALCE NIADMRARIG RVILAMSRDG KPISADDLGV
260 270 280 290 300
AGAMTAIMRD AIEPTLMQTL SGAPCLVHAG PFANIAHGNS SIIADRVALA
310 320 330 340 350
HHDYVVTEGG FGSDMGFEKF CNIKSRASGI APSAAVLVVT LRALKANSGV
360 370 380 390 400
EGDDRARLEA GFANLHWHMQ NVMGYGLPLV VAINRFPDDA MAELDWLKER
410 420 430 440 450
CLEEGAFGCE ISDAFSHGAE GARALATAVA RACDAPVNFE YLYDDEMDFG
460 470 480 490 500
ARLMTLAERY GAAGVSLSED ARRDLAMITE LGMDKLPLCM AKTPLSISHD
510 520 530 540 550
PSLKGAPSGF ELPVVGLRLS AGAGFITVLT GKVMTMPGLG LLPGYLNIDI
560
NDKGEIIGLG
Length:560
Mass (Da):59,201
Last modified:February 6, 2007 - v1
Checksum:iD41F2B8EC98CD7D6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000507 Genomic DNA. Translation: ABM01349.1.
RefSeqiWP_011761253.1. NC_008700.1.
YP_929018.1. NC_008700.1.

Genome annotation databases

EnsemblBacteriaiABM01349; ABM01349; Sama_3146.
GeneIDi4605393.
KEGGisaz:Sama_3146.
PATRICi23455187. VBISheAma74963_3240.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000507 Genomic DNA. Translation: ABM01349.1 .
RefSeqi WP_011761253.1. NC_008700.1.
YP_929018.1. NC_008700.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 326297.Sama_3146.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABM01349 ; ABM01349 ; Sama_3146 .
GeneIDi 4605393.
KEGGi saz:Sama_3146.
PATRICi 23455187. VBISheAma74963_3240.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi LKHHGGV.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci SAMA326297:GH0T-3266-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-1098 / SB2B.

Entry informationi

Entry nameiFTHS_SHEAM
AccessioniPrimary (citable) accession number: A1SAE2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: February 6, 2007
Last modified: November 26, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3