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Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Shewanella amazonensis (strain ATCC BAA-1098 / SB2B)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathway:itetrahydrofolate interconversion

This protein is involved in the pathway tetrahydrofolate interconversion, which is part of One-carbon metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway tetrahydrofolate interconversion and in One-carbon metabolism.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi62 – 698ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSAMA326297:GH0T-3266-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:Sama_3146
OrganismiShewanella amazonensis (strain ATCC BAA-1098 / SB2B)
Taxonomic identifieri326297 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
ProteomesiUP000009175 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 560560Formate--tetrahydrofolate ligasePRO_0000293058Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi326297.Sama_3146.

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiCGEIMTM.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1SAE2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLTDMEISRQ ANVRPIGWIA DDFGLGKHLW REAGHAMAKI SLEAARAPLR
60 70 80 90 100
GKLVIVTAVT PTPHGEGKTV TTIGLTQGLH LLGHKACACI RQPSLGPVFG
110 120 130 140 150
VKGGAAGGGY AQVVPMEVMN LHMTGDIHAV TSAHNLAAAA IDARLFHETR
160 170 180 190 200
LGCESFSAKT GLPALNIDPE RILWRRVVDH NDRSLRQIEL GLGDNNGPVH
210 220 230 240 250
GGGFDITAAS ELMAILALCE NIADMRARIG RVILAMSRDG KPISADDLGV
260 270 280 290 300
AGAMTAIMRD AIEPTLMQTL SGAPCLVHAG PFANIAHGNS SIIADRVALA
310 320 330 340 350
HHDYVVTEGG FGSDMGFEKF CNIKSRASGI APSAAVLVVT LRALKANSGV
360 370 380 390 400
EGDDRARLEA GFANLHWHMQ NVMGYGLPLV VAINRFPDDA MAELDWLKER
410 420 430 440 450
CLEEGAFGCE ISDAFSHGAE GARALATAVA RACDAPVNFE YLYDDEMDFG
460 470 480 490 500
ARLMTLAERY GAAGVSLSED ARRDLAMITE LGMDKLPLCM AKTPLSISHD
510 520 530 540 550
PSLKGAPSGF ELPVVGLRLS AGAGFITVLT GKVMTMPGLG LLPGYLNIDI
560
NDKGEIIGLG
Length:560
Mass (Da):59,201
Last modified:February 6, 2007 - v1
Checksum:iD41F2B8EC98CD7D6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000507 Genomic DNA. Translation: ABM01349.1.
RefSeqiWP_011761253.1. NC_008700.1.

Genome annotation databases

EnsemblBacteriaiABM01349; ABM01349; Sama_3146.
KEGGisaz:Sama_3146.
PATRICi23455187. VBISheAma74963_3240.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000507 Genomic DNA. Translation: ABM01349.1.
RefSeqiWP_011761253.1. NC_008700.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi326297.Sama_3146.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABM01349; ABM01349; Sama_3146.
KEGGisaz:Sama_3146.
PATRICi23455187. VBISheAma74963_3240.

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiCGEIMTM.
OrthoDBiEOG6PCPSP.

Enzyme and pathway databases

UniPathwayiUPA00193.
BioCyciSAMA326297:GH0T-3266-MONOMER.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-1098 / SB2B.

Entry informationi

Entry nameiFTHS_SHEAM
AccessioniPrimary (citable) accession number: A1SAE2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: February 6, 2007
Last modified: July 22, 2015
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.