Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

A1S965

- GCSP_SHEAM

UniProt

A1S965 - GCSP_SHEAM

Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Shewanella amazonensis (strain ATCC BAA-1098 / SB2B)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 57 (01 Oct 2014)
      Sequence version 1 (06 Feb 2007)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciSAMA326297:GH0T-2834-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-proteinUniRule annotation
    Glycine decarboxylaseUniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
    Gene namesi
    Name:gcvPUniRule annotation
    Ordered Locus Names:Sama_2719
    OrganismiShewanella amazonensis (strain ATCC BAA-1098 / SB2B)
    Taxonomic identifieri326297 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
    ProteomesiUP000009175: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 962962Glycine dehydrogenase (decarboxylating)PRO_1000045606Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei709 – 7091N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

    Protein-protein interaction databases

    STRINGi326297.Sama_2719.

    Structurei

    3D structure databases

    ProteinModelPortaliA1S965.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1003.
    HOGENOMiHOG000239369.
    KOiK00281.
    OMAiFDSRPYS.
    OrthoDBiEOG6HMXDX.

    Family and domain databases

    Gene3Di3.40.640.10. 2 hits.
    HAMAPiMF_00711. GcvP.
    InterProiIPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 2 hits.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 3 hits.
    TIGRFAMsiTIGR00461. gcvP. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A1S965-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTKQTLTELE QHELFLTRHI GPDADEQQAM LNYVGAESLE DLTAQIVPES    50
    IRLGRELNVG ASNGEAAGLA YIRQLADKNQ VFKSYIGMGY HGTEVPNVIL 100
    RNVLENPGWY TAYTPYQPEI AQGRLEAILN FQQLSIDLTG LDLASASLLD 150
    EATAAAEAMA LAKRVSKAKK ANTFFVADDV FPQTLDVVKT RAECFGFDIV 200
    TGPAAEAANH DDLFGALFQY TNRQGQLTDF TELFAQLRAK NVIVTVGADI 250
    MSLVLLKSPG AMGADVVFGS AQRFGVPMGF GGPHAAFFVS KDEHKRSMPG 300
    RIIGVSKDTR GKTALRMAMQ TREQHIRREK ANSNICTAQV LLANMASFYA 350
    VFHGPQGLKV IANRIHRLTD ILAAGLAAKG VTVLNTQWFD TLSFKVDVDA 400
    VRARALAAGV NLRYDADGVV GVSLAETTTR ADVAELFDII LGAGHGLDVA 450
    AIDADILAKG SSSIPAALVR EEAFLTHPTF NSYHSETEMM RYIKRLENKD 500
    LALNHSMISL GSCTMKLNAA VEMIPVSWPE FANMHPFCPS EQAQGYTQLI 550
    GELSDWLVDI TGYDAVCMQP NSGAQGEYAG LLAIRKYHES RGEGHRDVCL 600
    IPQSAHGTNP ASAQLAGMKV VVTACDKQGN VDLDDLRAKA AEVAENLSCI 650
    MITYPSTHGV YEETVREICD IIHQHGGQVY LDGANMNAQV GLTAPGFIGA 700
    DVSHLNLHKT FAIPHGGGGP GMGPIGVKKH LAPFVAGHAV VKQGIESDNN 750
    GAVSAAPFGS AGILPISWMY IKLLGSKGLK QSTQTAMLNA NYLTKKLSEH 800
    YPVLYRGRND RIAHECIIDM RPLKEASGVT EMDVAKRLND YGFHAPTMSF 850
    PVAGTLMIEP TESESKAELD RFIEAMVAIR GEIARVESGE WPVDNNPLAN 900
    APHTMDDIMD PAFDSRPYSR ELAVFPTESV RANKFWPTVN RIDDVYGDRN 950
    LFCACVPMSD YE 962
    Length:962
    Mass (Da):104,438
    Last modified:February 6, 2007 - v1
    Checksum:i61179B208FD5969C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000507 Genomic DNA. Translation: ABM00922.1.
    RefSeqiWP_011760827.1. NC_008700.1.
    YP_928591.1. NC_008700.1.

    Genome annotation databases

    EnsemblBacteriaiABM00922; ABM00922; Sama_2719.
    GeneIDi4604966.
    KEGGisaz:Sama_2719.
    PATRICi23454285. VBISheAma74963_2794.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000507 Genomic DNA. Translation: ABM00922.1 .
    RefSeqi WP_011760827.1. NC_008700.1.
    YP_928591.1. NC_008700.1.

    3D structure databases

    ProteinModelPortali A1S965.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 326297.Sama_2719.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABM00922 ; ABM00922 ; Sama_2719 .
    GeneIDi 4604966.
    KEGGi saz:Sama_2719.
    PATRICi 23454285. VBISheAma74963_2794.

    Phylogenomic databases

    eggNOGi COG1003.
    HOGENOMi HOG000239369.
    KOi K00281.
    OMAi FDSRPYS.
    OrthoDBi EOG6HMXDX.

    Enzyme and pathway databases

    BioCyci SAMA326297:GH0T-2834-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 2 hits.
    HAMAPi MF_00711. GcvP.
    InterProi IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 2 hits.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 3 hits.
    TIGRFAMsi TIGR00461. gcvP. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-1098 / SB2B.

    Entry informationi

    Entry nameiGCSP_SHEAM
    AccessioniPrimary (citable) accession number: A1S965
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: February 6, 2007
    Last modified: October 1, 2014
    This is version 57 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3