Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

A1S965 (GCSP_SHEAM) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glycine dehydrogenase (decarboxylating)

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene names
Name:gcvP
Ordered Locus Names:Sama_2719
OrganismShewanella amazonensis (strain ATCC BAA-1098 / SB2B) [Complete proteome] [HAMAP]
Taxonomic identifier326297 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella

Protein attributes

Sequence length962 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00711

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00711

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_00711

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Sequence similarities

Belongs to the GcvP family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 962962Glycine dehydrogenase (decarboxylating) HAMAP-Rule MF_00711
PRO_1000045606

Amino acid modifications

Modified residue7091N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
A1S965 [UniParc].

Last modified February 6, 2007. Version 1.
Checksum: 61179B208FD5969C

FASTA962104,438
        10         20         30         40         50         60 
MTKQTLTELE QHELFLTRHI GPDADEQQAM LNYVGAESLE DLTAQIVPES IRLGRELNVG 

        70         80         90        100        110        120 
ASNGEAAGLA YIRQLADKNQ VFKSYIGMGY HGTEVPNVIL RNVLENPGWY TAYTPYQPEI 

       130        140        150        160        170        180 
AQGRLEAILN FQQLSIDLTG LDLASASLLD EATAAAEAMA LAKRVSKAKK ANTFFVADDV 

       190        200        210        220        230        240 
FPQTLDVVKT RAECFGFDIV TGPAAEAANH DDLFGALFQY TNRQGQLTDF TELFAQLRAK 

       250        260        270        280        290        300 
NVIVTVGADI MSLVLLKSPG AMGADVVFGS AQRFGVPMGF GGPHAAFFVS KDEHKRSMPG 

       310        320        330        340        350        360 
RIIGVSKDTR GKTALRMAMQ TREQHIRREK ANSNICTAQV LLANMASFYA VFHGPQGLKV 

       370        380        390        400        410        420 
IANRIHRLTD ILAAGLAAKG VTVLNTQWFD TLSFKVDVDA VRARALAAGV NLRYDADGVV 

       430        440        450        460        470        480 
GVSLAETTTR ADVAELFDII LGAGHGLDVA AIDADILAKG SSSIPAALVR EEAFLTHPTF 

       490        500        510        520        530        540 
NSYHSETEMM RYIKRLENKD LALNHSMISL GSCTMKLNAA VEMIPVSWPE FANMHPFCPS 

       550        560        570        580        590        600 
EQAQGYTQLI GELSDWLVDI TGYDAVCMQP NSGAQGEYAG LLAIRKYHES RGEGHRDVCL 

       610        620        630        640        650        660 
IPQSAHGTNP ASAQLAGMKV VVTACDKQGN VDLDDLRAKA AEVAENLSCI MITYPSTHGV 

       670        680        690        700        710        720 
YEETVREICD IIHQHGGQVY LDGANMNAQV GLTAPGFIGA DVSHLNLHKT FAIPHGGGGP 

       730        740        750        760        770        780 
GMGPIGVKKH LAPFVAGHAV VKQGIESDNN GAVSAAPFGS AGILPISWMY IKLLGSKGLK 

       790        800        810        820        830        840 
QSTQTAMLNA NYLTKKLSEH YPVLYRGRND RIAHECIIDM RPLKEASGVT EMDVAKRLND 

       850        860        870        880        890        900 
YGFHAPTMSF PVAGTLMIEP TESESKAELD RFIEAMVAIR GEIARVESGE WPVDNNPLAN 

       910        920        930        940        950        960 
APHTMDDIMD PAFDSRPYSR ELAVFPTESV RANKFWPTVN RIDDVYGDRN LFCACVPMSD 


YE 

« Hide

References

[1]"Complete sequence of Shewanella amazonensis SB2B."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Munk A.C., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J. expand/collapse author list , Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Fredrickson J., Richardson P.
Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-1098 / SB2B.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000507 Genomic DNA. Translation: ABM00922.1.
RefSeqYP_928591.1. NC_008700.1.

3D structure databases

ProteinModelPortalA1S965.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING326297.Sama_2719.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABM00922; ABM00922; Sama_2719.
GeneID4604966.
KEGGsaz:Sama_2719.
PATRIC23454285. VBISheAma74963_2794.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1003.
HOGENOMHOG000239369.
KOK00281.
OMAFDSRPYS.
OrthoDBEOG6HMXDX.

Enzyme and pathway databases

BioCycSAMA326297:GH0T-2834-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 2 hits.
HAMAPMF_00711. GcvP.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMSSF53383. SSF53383. 3 hits.
TIGRFAMsTIGR00461. gcvP. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSP_SHEAM
AccessionPrimary (citable) accession number: A1S965
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 6, 2007
Last modified: May 14, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families