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A1S965

- GCSP_SHEAM

UniProt

A1S965 - GCSP_SHEAM

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Protein
Glycine dehydrogenase (decarboxylating)
Gene
gcvP, Sama_2719
Organism
Shewanella amazonensis (strain ATCC BAA-1098 / SB2B)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciSAMA326297:GH0T-2834-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating) (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene namesi
Name:gcvP
Ordered Locus Names:Sama_2719
OrganismiShewanella amazonensis (strain ATCC BAA-1098 / SB2B)
Taxonomic identifieri326297 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
ProteomesiUP000009175: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 962962Glycine dehydrogenase (decarboxylating)UniRule annotation
PRO_1000045606Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei709 – 7091N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Protein-protein interaction databases

STRINGi326297.Sama_2719.

Structurei

3D structure databases

ProteinModelPortaliA1S965.

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiFDSRPYS.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

A1S965-1 [UniParc]FASTAAdd to Basket

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MTKQTLTELE QHELFLTRHI GPDADEQQAM LNYVGAESLE DLTAQIVPES    50
IRLGRELNVG ASNGEAAGLA YIRQLADKNQ VFKSYIGMGY HGTEVPNVIL 100
RNVLENPGWY TAYTPYQPEI AQGRLEAILN FQQLSIDLTG LDLASASLLD 150
EATAAAEAMA LAKRVSKAKK ANTFFVADDV FPQTLDVVKT RAECFGFDIV 200
TGPAAEAANH DDLFGALFQY TNRQGQLTDF TELFAQLRAK NVIVTVGADI 250
MSLVLLKSPG AMGADVVFGS AQRFGVPMGF GGPHAAFFVS KDEHKRSMPG 300
RIIGVSKDTR GKTALRMAMQ TREQHIRREK ANSNICTAQV LLANMASFYA 350
VFHGPQGLKV IANRIHRLTD ILAAGLAAKG VTVLNTQWFD TLSFKVDVDA 400
VRARALAAGV NLRYDADGVV GVSLAETTTR ADVAELFDII LGAGHGLDVA 450
AIDADILAKG SSSIPAALVR EEAFLTHPTF NSYHSETEMM RYIKRLENKD 500
LALNHSMISL GSCTMKLNAA VEMIPVSWPE FANMHPFCPS EQAQGYTQLI 550
GELSDWLVDI TGYDAVCMQP NSGAQGEYAG LLAIRKYHES RGEGHRDVCL 600
IPQSAHGTNP ASAQLAGMKV VVTACDKQGN VDLDDLRAKA AEVAENLSCI 650
MITYPSTHGV YEETVREICD IIHQHGGQVY LDGANMNAQV GLTAPGFIGA 700
DVSHLNLHKT FAIPHGGGGP GMGPIGVKKH LAPFVAGHAV VKQGIESDNN 750
GAVSAAPFGS AGILPISWMY IKLLGSKGLK QSTQTAMLNA NYLTKKLSEH 800
YPVLYRGRND RIAHECIIDM RPLKEASGVT EMDVAKRLND YGFHAPTMSF 850
PVAGTLMIEP TESESKAELD RFIEAMVAIR GEIARVESGE WPVDNNPLAN 900
APHTMDDIMD PAFDSRPYSR ELAVFPTESV RANKFWPTVN RIDDVYGDRN 950
LFCACVPMSD YE 962
Length:962
Mass (Da):104,438
Last modified:February 6, 2007 - v1
Checksum:i61179B208FD5969C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000507 Genomic DNA. Translation: ABM00922.1.
RefSeqiWP_011760827.1. NC_008700.1.
YP_928591.1. NC_008700.1.

Genome annotation databases

EnsemblBacteriaiABM00922; ABM00922; Sama_2719.
GeneIDi4604966.
KEGGisaz:Sama_2719.
PATRICi23454285. VBISheAma74963_2794.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000507 Genomic DNA. Translation: ABM00922.1 .
RefSeqi WP_011760827.1. NC_008700.1.
YP_928591.1. NC_008700.1.

3D structure databases

ProteinModelPortali A1S965.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 326297.Sama_2719.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABM00922 ; ABM00922 ; Sama_2719 .
GeneIDi 4604966.
KEGGi saz:Sama_2719.
PATRICi 23454285. VBISheAma74963_2794.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
KOi K00281.
OMAi FDSRPYS.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci SAMA326297:GH0T-2834-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-1098 / SB2B.

Entry informationi

Entry nameiGCSP_SHEAM
AccessioniPrimary (citable) accession number: A1S965
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 6, 2007
Last modified: September 3, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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