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Protein

Probable nicotinate-nucleotide adenylyltransferase

Gene

nadD

Organism
Shewanella amazonensis (strain ATCC BAA-1098 / SB2B)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).UniRule annotation

Catalytic activityi

ATP + beta-nicotinate-D-ribonucleotide = diphosphate + deamido-NAD+.UniRule annotation

Pathwayi: NAD(+) biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes deamido-NAD(+) from nicotinate D-ribonucleotide.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Probable nicotinate-nucleotide adenylyltransferase (nadD)
This subpathway is part of the pathway NAD(+) biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes deamido-NAD(+) from nicotinate D-ribonucleotide, the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNucleotidyltransferase, Transferase
Biological processPyridine nucleotide biosynthesis
LigandATP-binding, NAD, Nucleotide-binding

Enzyme and pathway databases

BioCyciSAMA326297:G1G7Q-2717-MONOMER
UniPathwayiUPA00253; UER00332

Names & Taxonomyi

Protein namesi
Recommended name:
Probable nicotinate-nucleotide adenylyltransferaseUniRule annotation (EC:2.7.7.18UniRule annotation)
Alternative name(s):
Deamido-NAD(+) diphosphorylaseUniRule annotation
Deamido-NAD(+) pyrophosphorylaseUniRule annotation
Nicotinate mononucleotide adenylyltransferaseUniRule annotation
Short name:
NaMN adenylyltransferaseUniRule annotation
Gene namesi
Name:nadDUniRule annotation
Ordered Locus Names:Sama_2585
OrganismiShewanella amazonensis (strain ATCC BAA-1098 / SB2B)
Taxonomic identifieri326297 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
Proteomesi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003367371 – 216Probable nicotinate-nucleotide adenylyltransferaseAdd BLAST216

Proteomic databases

PRIDEiA1S8T1

Interactioni

Protein-protein interaction databases

STRINGi326297.Sama_2585

Structurei

3D structure databases

ProteinModelPortaliA1S8T1
SMRiA1S8T1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NadD family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108Z1W Bacteria
COG1057 LUCA
HOGENOMiHOG000262781
KOiK00969
OMAiIHIGHLI
OrthoDBiPOG091H028Y

Family and domain databases

CDDicd02165 NMNAT, 1 hit
Gene3Di3.40.50.620, 1 hit
HAMAPiMF_00244 NaMN_adenylyltr, 1 hit
InterProiView protein in InterPro
IPR004821 Cyt_trans-like
IPR005248 NadD/NMNAT
IPR014729 Rossmann-like_a/b/a_fold
PfamiView protein in Pfam
PF01467 CTP_transf_like, 1 hit
TIGRFAMsiTIGR00482 TIGR00482, 1 hit

Sequencei

Sequence statusi: Complete.

A1S8T1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKQPNAKRH TALLGGTFDP PHFGHIRPLL DVLKHWPLQD CWLLPNHIPP
60 70 80 90 100
HKPGTHASPK ARLEMIDALC REFPAFSLCD VELRRDEPSY TVNTLRQLRE
110 120 130 140 150
LYPDRVFYFV MGMDSFLSLD KWFEWQQLFE LCHLVVCARP GYQLAADHGM
160 170 180 190 200
AEVLANRQHT EADLPAEDSG KVLIADIREQ DISSTDIRTA LAERRDIRQL
210
VPESVARVIE TQGLYR
Length:216
Mass (Da):24,876
Last modified:February 6, 2007 - v1
Checksum:iDE64E6C8F1993B9E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000507 Genomic DNA Translation: ABM00788.1
RefSeqiWP_011760694.1, NC_008700.1

Genome annotation databases

EnsemblBacteriaiABM00788; ABM00788; Sama_2585
KEGGisaz:Sama_2585

Entry informationi

Entry nameiNADD_SHEAM
AccessioniPrimary (citable) accession number: A1S8T1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 6, 2007
Last modified: May 23, 2018
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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