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A1S8S8

- SYL_SHEAM

UniProt

A1S8S8 - SYL_SHEAM

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Protein

Leucine--tRNA ligase

Gene
leuS, Sama_2582
Organism
Shewanella amazonensis (strain ATCC BAA-1098 / SB2B)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei621 – 6211ATP By similarity

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSAMA326297:GH0T-2687-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:Sama_2582
OrganismiShewanella amazonensis (strain ATCC BAA-1098 / SB2B)
Taxonomic identifieri326297 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
ProteomesiUP000009175: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 859859Leucine--tRNA ligaseUniRule annotationPRO_0000334812Add
BLAST

Proteomic databases

PRIDEiA1S8S8.

Interactioni

Protein-protein interaction databases

STRINGi326297.Sama_2582.

Structurei

3D structure databases

ProteinModelPortaliA1S8S8.
SMRiA1S8S8. Positions 228-412.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi42 – 5211"HIGH" regionUniRule annotationAdd
BLAST
Motifi618 – 6225"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1S8S8-1 [UniParc]FASTAAdd to Basket

« Hide

MQEQYIHSEI EAEVQKYWAD NKTFEVTEDP AKEKFYCLSM FPYPSGRLHM    50
GHVRNYTIGD VVARFQRLQG KNVLQPIGWD AFGLPAENAA IKNATAPAPW 100
TYENIDYMKN QLKMLGFGYD WSREIATCTP EYYRWEQWFF TKLYEKGLVY 150
KKTSAVNWCP NDQTVLANEQ VQDGCCWRCD TPVEQKEIPQ WFIKITAYAE 200
ELLNDIDNLE GWPEQVKTMQ RNWIGRSEGV EMTFKVKDSD DSFDIYTTRP 250
DTVMGVTYVA IAAGHPLAEK AALNNPELAA FVEECKQSGT SEAELATMEK 300
KGVATGLYAI HPLTGEEVPV WAANFVLMNY GTGAVMSVPA HDQRDYEFAK 350
KYGLALKAVI KPADGEVDIS EAAYTEKGVL FNSAEFDGLD FDGAFNAIAD 400
KLAAEGKGKR QVNFRLRDWG VSRQRYWGAP IPMVTLEDGT VMPTPEDQLP 450
VILPEDVVMD GVQSPIKADK EWAKTQVNGQ DALRETDTFD TFMESSWYYA 500
RYCSPKANEM LDPAKANYWL PVDQYIGGIE HACMHLLYFR FFHKLLRDAG 550
LVNSNEPAKR LLTQGMVLAD AFYYNNEKGA RVWVSPLDVT VVEKDDKGRI 600
LKAVDTEGHE LVYTGMSKMS KSKNNGIDPQ VMVEKYGADT VRLFMMFASP 650
PELTLEWQES GVEGAHRFIK RLWKLASEYS AAPATEALDV SALNADQKTL 700
RRELHKTIAK VTDDLGRRQM FNTAVAAVME LMNHLQKAPL ASAQDKALMN 750
EALSAVVRLL YPIAPHVCFN LWRELGNSGA IEDAGWPATD ESALVEDSKL 800
IVVQVNGKVR AKLTVAADAT KEQVEALGLA EDAVRKYTDG VTVRKVIYVP 850
GKLLNIVAN 859
Length:859
Mass (Da):96,507
Last modified:May 20, 2008 - v2
Checksum:iE62046CFEC2DE27D
GO

Sequence cautioni

The sequence ABM00785.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000507 Genomic DNA. Translation: ABM00785.1. Different initiation.
RefSeqiYP_928454.1. NC_008700.1.

Genome annotation databases

EnsemblBacteriaiABM00785; ABM00785; Sama_2582.
GeneIDi4604829.
KEGGisaz:Sama_2582.
PATRICi23453987. VBISheAma74963_2655.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000507 Genomic DNA. Translation: ABM00785.1 . Different initiation.
RefSeqi YP_928454.1. NC_008700.1.

3D structure databases

ProteinModelPortali A1S8S8.
SMRi A1S8S8. Positions 228-412.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 326297.Sama_2582.

Proteomic databases

PRIDEi A1S8S8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABM00785 ; ABM00785 ; Sama_2582 .
GeneIDi 4604829.
KEGGi saz:Sama_2582.
PATRICi 23453987. VBISheAma74963_2655.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci SAMA326297:GH0T-2687-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-1098 / SB2B.

Entry informationi

Entry nameiSYL_SHEAM
AccessioniPrimary (citable) accession number: A1S8S8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: May 14, 2014
This is version 57 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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