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A1S8S8

- SYL_SHEAM

UniProt

A1S8S8 - SYL_SHEAM

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Shewanella amazonensis (strain ATCC BAA-1098 / SB2B)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 58 (01 Oct 2014)
      Sequence version 2 (20 May 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei621 – 6211ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSAMA326297:GH0T-2687-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:Sama_2582
    OrganismiShewanella amazonensis (strain ATCC BAA-1098 / SB2B)
    Taxonomic identifieri326297 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
    ProteomesiUP000009175: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 859859Leucine--tRNA ligasePRO_0000334812Add
    BLAST

    Proteomic databases

    PRIDEiA1S8S8.

    Interactioni

    Protein-protein interaction databases

    STRINGi326297.Sama_2582.

    Structurei

    3D structure databases

    ProteinModelPortaliA1S8S8.
    SMRiA1S8S8. Positions 228-412.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi42 – 5211"HIGH" regionAdd
    BLAST
    Motifi618 – 6225"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A1S8S8-1 [UniParc]FASTAAdd to Basket

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    MQEQYIHSEI EAEVQKYWAD NKTFEVTEDP AKEKFYCLSM FPYPSGRLHM    50
    GHVRNYTIGD VVARFQRLQG KNVLQPIGWD AFGLPAENAA IKNATAPAPW 100
    TYENIDYMKN QLKMLGFGYD WSREIATCTP EYYRWEQWFF TKLYEKGLVY 150
    KKTSAVNWCP NDQTVLANEQ VQDGCCWRCD TPVEQKEIPQ WFIKITAYAE 200
    ELLNDIDNLE GWPEQVKTMQ RNWIGRSEGV EMTFKVKDSD DSFDIYTTRP 250
    DTVMGVTYVA IAAGHPLAEK AALNNPELAA FVEECKQSGT SEAELATMEK 300
    KGVATGLYAI HPLTGEEVPV WAANFVLMNY GTGAVMSVPA HDQRDYEFAK 350
    KYGLALKAVI KPADGEVDIS EAAYTEKGVL FNSAEFDGLD FDGAFNAIAD 400
    KLAAEGKGKR QVNFRLRDWG VSRQRYWGAP IPMVTLEDGT VMPTPEDQLP 450
    VILPEDVVMD GVQSPIKADK EWAKTQVNGQ DALRETDTFD TFMESSWYYA 500
    RYCSPKANEM LDPAKANYWL PVDQYIGGIE HACMHLLYFR FFHKLLRDAG 550
    LVNSNEPAKR LLTQGMVLAD AFYYNNEKGA RVWVSPLDVT VVEKDDKGRI 600
    LKAVDTEGHE LVYTGMSKMS KSKNNGIDPQ VMVEKYGADT VRLFMMFASP 650
    PELTLEWQES GVEGAHRFIK RLWKLASEYS AAPATEALDV SALNADQKTL 700
    RRELHKTIAK VTDDLGRRQM FNTAVAAVME LMNHLQKAPL ASAQDKALMN 750
    EALSAVVRLL YPIAPHVCFN LWRELGNSGA IEDAGWPATD ESALVEDSKL 800
    IVVQVNGKVR AKLTVAADAT KEQVEALGLA EDAVRKYTDG VTVRKVIYVP 850
    GKLLNIVAN 859
    Length:859
    Mass (Da):96,507
    Last modified:May 20, 2008 - v2
    Checksum:iE62046CFEC2DE27D
    GO

    Sequence cautioni

    The sequence ABM00785.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000507 Genomic DNA. Translation: ABM00785.1. Different initiation.
    RefSeqiYP_928454.1. NC_008700.1.

    Genome annotation databases

    EnsemblBacteriaiABM00785; ABM00785; Sama_2582.
    GeneIDi4604829.
    KEGGisaz:Sama_2582.
    PATRICi23453987. VBISheAma74963_2655.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000507 Genomic DNA. Translation: ABM00785.1 . Different initiation.
    RefSeqi YP_928454.1. NC_008700.1.

    3D structure databases

    ProteinModelPortali A1S8S8.
    SMRi A1S8S8. Positions 228-412.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 326297.Sama_2582.

    Proteomic databases

    PRIDEi A1S8S8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABM00785 ; ABM00785 ; Sama_2582 .
    GeneIDi 4604829.
    KEGGi saz:Sama_2582.
    PATRICi 23453987. VBISheAma74963_2655.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci SAMA326297:GH0T-2687-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-1098 / SB2B.

    Entry informationi

    Entry nameiSYL_SHEAM
    AccessioniPrimary (citable) accession number: A1S8S8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: May 20, 2008
    Last modified: October 1, 2014
    This is version 58 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3