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A1S8S8

- SYL_SHEAM

UniProt

A1S8S8 - SYL_SHEAM

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Shewanella amazonensis (strain ATCC BAA-1098 / SB2B)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei621 – 6211ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSAMA326297:GH0T-2687-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:Sama_2582
OrganismiShewanella amazonensis (strain ATCC BAA-1098 / SB2B)
Taxonomic identifieri326297 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
ProteomesiUP000009175: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 859859Leucine--tRNA ligasePRO_0000334812Add
BLAST

Proteomic databases

PRIDEiA1S8S8.

Interactioni

Protein-protein interaction databases

STRINGi326297.Sama_2582.

Structurei

3D structure databases

ProteinModelPortaliA1S8S8.
SMRiA1S8S8. Positions 228-412.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi42 – 5211"HIGH" regionAdd
BLAST
Motifi618 – 6225"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1S8S8 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQEQYIHSEI EAEVQKYWAD NKTFEVTEDP AKEKFYCLSM FPYPSGRLHM
60 70 80 90 100
GHVRNYTIGD VVARFQRLQG KNVLQPIGWD AFGLPAENAA IKNATAPAPW
110 120 130 140 150
TYENIDYMKN QLKMLGFGYD WSREIATCTP EYYRWEQWFF TKLYEKGLVY
160 170 180 190 200
KKTSAVNWCP NDQTVLANEQ VQDGCCWRCD TPVEQKEIPQ WFIKITAYAE
210 220 230 240 250
ELLNDIDNLE GWPEQVKTMQ RNWIGRSEGV EMTFKVKDSD DSFDIYTTRP
260 270 280 290 300
DTVMGVTYVA IAAGHPLAEK AALNNPELAA FVEECKQSGT SEAELATMEK
310 320 330 340 350
KGVATGLYAI HPLTGEEVPV WAANFVLMNY GTGAVMSVPA HDQRDYEFAK
360 370 380 390 400
KYGLALKAVI KPADGEVDIS EAAYTEKGVL FNSAEFDGLD FDGAFNAIAD
410 420 430 440 450
KLAAEGKGKR QVNFRLRDWG VSRQRYWGAP IPMVTLEDGT VMPTPEDQLP
460 470 480 490 500
VILPEDVVMD GVQSPIKADK EWAKTQVNGQ DALRETDTFD TFMESSWYYA
510 520 530 540 550
RYCSPKANEM LDPAKANYWL PVDQYIGGIE HACMHLLYFR FFHKLLRDAG
560 570 580 590 600
LVNSNEPAKR LLTQGMVLAD AFYYNNEKGA RVWVSPLDVT VVEKDDKGRI
610 620 630 640 650
LKAVDTEGHE LVYTGMSKMS KSKNNGIDPQ VMVEKYGADT VRLFMMFASP
660 670 680 690 700
PELTLEWQES GVEGAHRFIK RLWKLASEYS AAPATEALDV SALNADQKTL
710 720 730 740 750
RRELHKTIAK VTDDLGRRQM FNTAVAAVME LMNHLQKAPL ASAQDKALMN
760 770 780 790 800
EALSAVVRLL YPIAPHVCFN LWRELGNSGA IEDAGWPATD ESALVEDSKL
810 820 830 840 850
IVVQVNGKVR AKLTVAADAT KEQVEALGLA EDAVRKYTDG VTVRKVIYVP

GKLLNIVAN
Length:859
Mass (Da):96,507
Last modified:May 20, 2008 - v2
Checksum:iE62046CFEC2DE27D
GO

Sequence cautioni

The sequence ABM00785.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000507 Genomic DNA. Translation: ABM00785.1. Different initiation.
RefSeqiYP_928454.1. NC_008700.1.

Genome annotation databases

EnsemblBacteriaiABM00785; ABM00785; Sama_2582.
GeneIDi4604829.
KEGGisaz:Sama_2582.
PATRICi23453987. VBISheAma74963_2655.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000507 Genomic DNA. Translation: ABM00785.1 . Different initiation.
RefSeqi YP_928454.1. NC_008700.1.

3D structure databases

ProteinModelPortali A1S8S8.
SMRi A1S8S8. Positions 228-412.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 326297.Sama_2582.

Proteomic databases

PRIDEi A1S8S8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABM00785 ; ABM00785 ; Sama_2582 .
GeneIDi 4604829.
KEGGi saz:Sama_2582.
PATRICi 23453987. VBISheAma74963_2655.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci SAMA326297:GH0T-2687-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-1098 / SB2B.

Entry informationi

Entry nameiSYL_SHEAM
AccessioniPrimary (citable) accession number: A1S8S8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: October 29, 2014
This is version 59 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3