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A1S7L6

- FADJ_SHEAM

UniProt

A1S7L6 - FADJ_SHEAM

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Protein
Fatty acid oxidation complex subunit alpha
Gene
fadJ, Sama_2167
Organism
Shewanella amazonensis (strain ATCC BAA-1098 / SB2B)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the formation of a hydroxyacyl-CoA by addition of water on enoyl-CoA. Also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities By similarity.UniRule annotation

Catalytic activityi

(3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl-CoA + H2O.UniRule annotation
(S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH.UniRule annotation
(S)-3-hydroxybutanoyl-CoA = (R)-3-hydroxybutanoyl-CoA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei116 – 1161Important for catalytic activity By similarity
Sitei138 – 1381Important for catalytic activity By similarity

GO - Molecular functioni

  1. 3-hydroxyacyl-CoA dehydrogenase activity Source: UniProtKB-HAMAP
  2. 3-hydroxybutyryl-CoA epimerase activity Source: UniProtKB-HAMAP
  3. NAD binding Source: InterPro
  4. enoyl-CoA hydratase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. fatty acid beta-oxidation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Lyase, Oxidoreductase

Keywords - Biological processi

Fatty acid metabolism, Lipid degradation, Lipid metabolism

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciSAMA326297:GH0T-2252-MONOMER.
UniPathwayiUPA00659.

Names & Taxonomyi

Protein namesi
Recommended name:
Fatty acid oxidation complex subunit alpha
Including the following 2 domains:
Enoyl-CoA hydratase/3-hydroxybutyryl-CoA epimerase (EC:4.2.1.17, EC:5.1.2.3)
3-hydroxyacyl-CoA dehydrogenase (EC:1.1.1.35)
Gene namesi
Name:fadJ
Ordered Locus Names:Sama_2167
OrganismiShewanella amazonensis (strain ATCC BAA-1098 / SB2B)
Taxonomic identifieri326297 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
ProteomesiUP000009175: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 706706Fatty acid oxidation complex subunit alphaUniRule annotation
PRO_0000323525Add
BLAST

Interactioni

Subunit structurei

Heterotetramer of two alpha chains (FadJ) and two beta chains (FadI) By similarity.

Protein-protein interaction databases

STRINGi326297.Sama_2167.

Structurei

3D structure databases

ProteinModelPortaliA1S7L6.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 188188Enoyl-CoA hydratase By similarity
Add
BLAST
Regioni308 – 7063993-hydroxyacyl-CoA dehydrogenase By similarity
Add
BLAST

Sequence similaritiesi

In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.
In the central section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family.

Phylogenomic databases

eggNOGiCOG1250.
HOGENOMiHOG000261344.
KOiK01782.
OMAiPFRYMDT.
OrthoDBiEOG6M9F0M.

Family and domain databases

Gene3Di1.10.1040.10. 2 hits.
3.40.50.720. 1 hit.
3.90.226.10. 1 hit.
HAMAPiMF_01617. FadJ.
InterProiIPR006176. 3-OHacyl-CoA_DH_NAD-bd.
IPR006108. 3HC_DH_C.
IPR008927. 6-PGluconate_DH_C-like.
IPR029045. ClpP/crotonase-like_dom.
IPR001753. Crotonase_core_superfam.
IPR013328. DH_multihelical.
IPR012802. FadJ.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00725. 3HCDH. 2 hits.
PF02737. 3HCDH_N. 1 hit.
PF00378. ECH. 1 hit.
[Graphical view]
SUPFAMiSSF48179. SSF48179. 2 hits.
SSF52096. SSF52096. 1 hit.
TIGRFAMsiTIGR02440. FadJ. 1 hit.

Sequencei

Sequence statusi: Complete.

A1S7L6-1 [UniParc]FASTAAdd to Basket

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MEKTFSLSRR DDGIALLTMD VPGETMNTLK AQFAPEITAI LQEIKADSSI    50
KGLVLISGKA DSFVAGADIS MLDACETAED ARLLSRQGHH VFAELEGLNI 100
PVVAAIHGAC LGGGLELALA CHQRVCSDSS KTMLGVPEVQ LGLLPGGGGT 150
QRLPRLIGIA KALDLMLTGK QVRPKQAVKM GLVDDVVPES ILLDTAIEMA 200
LAGKKTRKPL KQPLVTKLLE GTPVGRNIMF DQATKQVLKK TQGNYPSPLK 250
IIDCVREGMA KGMEKGLEVE AAHFGALVAT PESAALRSIF FATTEMKKET 300
GAGDAKPRKV AKAVVLGGGL MGGGIASVTT TKAKVPVRVK DISDKGLSNA 350
LGYAYKLLDK GVKRRHMTSA ERDKLMALMT TTTEYRGVKD ADIVVEAVFE 400
DLNLKHQMVR DIERECGEHT IFASNTSSLP ITQIAAAASR PENVIGLHYF 450
SPVEKMPLVE VIAHEKTSPE TIATTVAFAR KQGKTPIVVK DCAGFYVNRI 500
LALYMNEAAQ LLLEGQAVDH LDKALVKFGF PVGPMTLLDE VGIDVGAKIS 550
PILEKELGER FKAPAAFDKL MADDRKGRKN GKGFYLYGKA AKKGKKVDES 600
VYSLLGLTPA TGKEAGEIAE RCVVQMLNEA VRCLEEGIIA SPRDGDIGAI 650
FGIGFPPFLG GPFRYMDTLG AAKMVRLLEG YQSKYGDRFA PAALLKAMAA 700
EGKTFY 706
Length:706
Mass (Da):75,699
Last modified:February 6, 2007 - v1
Checksum:iC724364647D18D6F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000507 Genomic DNA. Translation: ABM00373.1.
RefSeqiYP_928042.1. NC_008700.1.

Genome annotation databases

EnsemblBacteriaiABM00373; ABM00373; Sama_2167.
GeneIDi4604417.
KEGGisaz:Sama_2167.
PATRICi23453115. VBISheAma74963_2238.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000507 Genomic DNA. Translation: ABM00373.1 .
RefSeqi YP_928042.1. NC_008700.1.

3D structure databases

ProteinModelPortali A1S7L6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 326297.Sama_2167.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABM00373 ; ABM00373 ; Sama_2167 .
GeneIDi 4604417.
KEGGi saz:Sama_2167.
PATRICi 23453115. VBISheAma74963_2238.

Phylogenomic databases

eggNOGi COG1250.
HOGENOMi HOG000261344.
KOi K01782.
OMAi PFRYMDT.
OrthoDBi EOG6M9F0M.

Enzyme and pathway databases

UniPathwayi UPA00659 .
BioCyci SAMA326297:GH0T-2252-MONOMER.

Family and domain databases

Gene3Di 1.10.1040.10. 2 hits.
3.40.50.720. 1 hit.
3.90.226.10. 1 hit.
HAMAPi MF_01617. FadJ.
InterProi IPR006176. 3-OHacyl-CoA_DH_NAD-bd.
IPR006108. 3HC_DH_C.
IPR008927. 6-PGluconate_DH_C-like.
IPR029045. ClpP/crotonase-like_dom.
IPR001753. Crotonase_core_superfam.
IPR013328. DH_multihelical.
IPR012802. FadJ.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
Pfami PF00725. 3HCDH. 2 hits.
PF02737. 3HCDH_N. 1 hit.
PF00378. ECH. 1 hit.
[Graphical view ]
SUPFAMi SSF48179. SSF48179. 2 hits.
SSF52096. SSF52096. 1 hit.
TIGRFAMsi TIGR02440. FadJ. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-1098 / SB2B.

Entry informationi

Entry nameiFADJ_SHEAM
AccessioniPrimary (citable) accession number: A1S7L6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: February 6, 2007
Last modified: June 11, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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