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A1S7A8

- A1S7A8_SHEAM

UniProt

A1S7A8 - A1S7A8_SHEAM

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Protein
Submitted name:

Isocitrate dehydrogenase (NADP(+))

Gene
Sama_2059
Organism
Shewanella amazonensis (strain ATCC BAA-1098 / SB2B)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein predictedi

Functioni

Cofactori

Binds 1 magnesium or manganese ion per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei147 – 1471Substrate By similarityUniRule annotation
Sitei257 – 2571Critical for catalysis By similarityUniRule annotation
Metal bindingi352 – 3521Magnesium or manganese By similarityUniRule annotation
Sitei422 – 4221Critical for catalysis By similarityUniRule annotation
Binding sitei549 – 5491Substrate By similarityUniRule annotation
Metal bindingi550 – 5501Magnesium or manganese By similarityUniRule annotation
Metal bindingi554 – 5541Magnesium or manganese By similarityUniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseImported

Keywords - Ligandi

MagnesiumUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

BioCyciSAMA326297:GH0T-2136-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Isocitrate dehydrogenase (NADP(+))Imported (EC:1.1.1.42Imported)
Gene namesi
Ordered Locus Names:Sama_2059Imported
OrganismiShewanella amazonensis (strain ATCC BAA-1098 / SB2B)Imported
Taxonomic identifieri326297 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
ProteomesiUP000009175: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi326297.Sama_2059.

Structurei

3D structure databases

ProteinModelPortaliA1S7A8.
SMRiA1S7A8. Positions 5-740.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni134 – 1418Substrate binding By similarityUniRule annotation

Phylogenomic databases

eggNOGiCOG2838.
HOGENOMiHOG000240860.
KOiK00031.
OMAiEEQRIGD.
OrthoDBiEOG6DVJPP.

Family and domain databases

Gene3Di3.40.718.10. 3 hits.
InterProiIPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PfamiPF03971. IDH. 1 hit.
[Graphical view]
PIRSFiPIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsiTIGR00178. monomer_idh. 1 hit.

Sequencei

Sequence statusi: Complete.

A1S7A8-1 [UniParc]FASTAAdd to Basket

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MKDNSPTIIY TETDEAPALA TLSLLPILQT FAEPAGVKIE TRDISLSGRV    50
IATFPEKLTD AQRIGDHLAE LGELATKPEA NIIKLPNISA SIPQLKACIK 100
ELQAQGYDIP NYPEEPKTDE EKSIKARYDK IKGSAVNPVL REGNSDRRAP 150
LSVKNYARKN PHSMGKWASD SKSHVSHMEA GDFYGSEQSV TLADADSVSI 200
VHTSKAGVET VLKSGLKLQA GEIIDSAVMS KNALVAFFER EIEAAKAEDV 250
LLSLHLKATM MKVSDPIMFG HAVKVFFKPL FAKHAETFER LGVDVNNGFG 300
DVVAKIQSLP EAERAAIEAD IQAVYAERPA MAMVNSDKGI TNLHVPSDII 350
IDASMPAAIR SSGQMWGPDG QLKDTKFMIP DRCYAGVYDA TINFCKAHGA 400
FDPRTMGTIP NVGLMAQKAE EYGSHDKTFE IAEDGVVTVV NAAGSVLMSH 450
TVEAGDIFRM CQVKDAPIQD WVKLAVRRAR LSETPAVFWL DKNRAHDAEL 500
IKKVEAYLPQ HDTSGLEIHI MSPVEATQFS LARMKDGKDT ISVTGNVLRD 550
YLTDLFPILE LGTSAKMLSI VPLMNGGGLF ETGAGGSAPK HVEQVQSENY 600
LRWDSLGEFL ALAASFEHLA QTAGVAKAQV LADTLDTAIG KFLDENKSPA 650
RRVGQIDNRG SHFYLAMYWA QALAAQTADA ELAAHFGQLA DKLAANEETI 700
LAELIGVQGH SVDLGGYYRP DFAKASAVMR PSATLNGLMS H 741
Length:741
Mass (Da):80,332
Last modified:February 6, 2007 - v1
Checksum:i0B4691F910BB655C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000507 Genomic DNA. Translation: ABM00265.1.
RefSeqiWP_011760172.1. NC_008700.1.
YP_927934.1. NC_008700.1.

Genome annotation databases

EnsemblBacteriaiABM00265; ABM00265; Sama_2059.
GeneIDi4604309.
KEGGisaz:Sama_2059.
PATRICi23452873. VBISheAma74963_2125.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000507 Genomic DNA. Translation: ABM00265.1 .
RefSeqi WP_011760172.1. NC_008700.1.
YP_927934.1. NC_008700.1.

3D structure databases

ProteinModelPortali A1S7A8.
SMRi A1S7A8. Positions 5-740.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 326297.Sama_2059.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABM00265 ; ABM00265 ; Sama_2059 .
GeneIDi 4604309.
KEGGi saz:Sama_2059.
PATRICi 23452873. VBISheAma74963_2125.

Phylogenomic databases

eggNOGi COG2838.
HOGENOMi HOG000240860.
KOi K00031.
OMAi EEQRIGD.
OrthoDBi EOG6DVJPP.

Enzyme and pathway databases

BioCyci SAMA326297:GH0T-2136-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 3 hits.
InterProi IPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
Pfami PF03971. IDH. 1 hit.
[Graphical view ]
PIRSFi PIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsi TIGR00178. monomer_idh. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-1098 / SB2B.

Entry informationi

Entry nameiA1S7A8_SHEAM
AccessioniPrimary (citable) accession number: A1S7A8
Entry historyi
Integrated into UniProtKB/TrEMBL: February 6, 2007
Last sequence update: February 6, 2007
Last modified: September 3, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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