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A1S7A8

- A1S7A8_SHEAM

UniProt

A1S7A8 - A1S7A8_SHEAM

Protein
Submitted name:

Isocitrate dehydrogenase (NADP(+))

Gene

Sama_2059

Organism
Shewanella amazonensis (strain ATCC BAA-1098 / SB2B)
Status
Unreviewed - Annotation score: 2 out of 5- Protein predictedi
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    • History
      Entry version 50 (01 Oct 2014)
      Sequence version 1 (06 Feb 2007)
      Previous versions | rss
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    Functioni

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei147 – 1471Substrate
    Sitei257 – 2571Critical for catalysisUniRule annotation
    Metal bindingi352 – 3521Magnesium or manganeseUniRule annotation
    Sitei422 – 4221Critical for catalysisUniRule annotation
    Binding sitei549 – 5491SubstrateUniRule annotation
    Metal bindingi550 – 5501Magnesium or manganeseUniRule annotation
    Metal bindingi554 – 5541Magnesium or manganeseUniRule annotation

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. tricarboxylic acid cycle Source: InterPro

    Keywords - Molecular functioni

    OxidoreductaseImported

    Keywords - Ligandi

    MagnesiumUniRule annotation, Metal-bindingUniRule annotation

    Enzyme and pathway databases

    BioCyciSAMA326297:GH0T-2136-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Isocitrate dehydrogenase (NADP(+))Imported (EC:1.1.1.42Imported)
    Gene namesi
    Ordered Locus Names:Sama_2059Imported
    OrganismiShewanella amazonensis (strain ATCC BAA-1098 / SB2B)Imported
    Taxonomic identifieri326297 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
    ProteomesiUP000009175: Chromosome

    Interactioni

    Protein-protein interaction databases

    STRINGi326297.Sama_2059.

    Structurei

    3D structure databases

    ProteinModelPortaliA1S7A8.
    SMRiA1S7A8. Positions 5-740.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni134 – 1418Substrate binding

    Phylogenomic databases

    eggNOGiCOG2838.
    HOGENOMiHOG000240860.
    KOiK00031.
    OMAiEEQRIGD.
    OrthoDBiEOG6DVJPP.

    Family and domain databases

    Gene3Di3.40.718.10. 3 hits.
    InterProiIPR004436. Isocitrate_DH_NADP_mono.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PfamiPF03971. IDH. 1 hit.
    [Graphical view]
    PIRSFiPIRSF009407. IDH_monmr. 1 hit.
    TIGRFAMsiTIGR00178. monomer_idh. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A1S7A8-1 [UniParc]FASTAAdd to Basket

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    MKDNSPTIIY TETDEAPALA TLSLLPILQT FAEPAGVKIE TRDISLSGRV    50
    IATFPEKLTD AQRIGDHLAE LGELATKPEA NIIKLPNISA SIPQLKACIK 100
    ELQAQGYDIP NYPEEPKTDE EKSIKARYDK IKGSAVNPVL REGNSDRRAP 150
    LSVKNYARKN PHSMGKWASD SKSHVSHMEA GDFYGSEQSV TLADADSVSI 200
    VHTSKAGVET VLKSGLKLQA GEIIDSAVMS KNALVAFFER EIEAAKAEDV 250
    LLSLHLKATM MKVSDPIMFG HAVKVFFKPL FAKHAETFER LGVDVNNGFG 300
    DVVAKIQSLP EAERAAIEAD IQAVYAERPA MAMVNSDKGI TNLHVPSDII 350
    IDASMPAAIR SSGQMWGPDG QLKDTKFMIP DRCYAGVYDA TINFCKAHGA 400
    FDPRTMGTIP NVGLMAQKAE EYGSHDKTFE IAEDGVVTVV NAAGSVLMSH 450
    TVEAGDIFRM CQVKDAPIQD WVKLAVRRAR LSETPAVFWL DKNRAHDAEL 500
    IKKVEAYLPQ HDTSGLEIHI MSPVEATQFS LARMKDGKDT ISVTGNVLRD 550
    YLTDLFPILE LGTSAKMLSI VPLMNGGGLF ETGAGGSAPK HVEQVQSENY 600
    LRWDSLGEFL ALAASFEHLA QTAGVAKAQV LADTLDTAIG KFLDENKSPA 650
    RRVGQIDNRG SHFYLAMYWA QALAAQTADA ELAAHFGQLA DKLAANEETI 700
    LAELIGVQGH SVDLGGYYRP DFAKASAVMR PSATLNGLMS H 741
    Length:741
    Mass (Da):80,332
    Last modified:February 6, 2007 - v1
    Checksum:i0B4691F910BB655C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000507 Genomic DNA. Translation: ABM00265.1.
    RefSeqiWP_011760172.1. NC_008700.1.
    YP_927934.1. NC_008700.1.

    Genome annotation databases

    EnsemblBacteriaiABM00265; ABM00265; Sama_2059.
    GeneIDi4604309.
    KEGGisaz:Sama_2059.
    PATRICi23452873. VBISheAma74963_2125.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000507 Genomic DNA. Translation: ABM00265.1 .
    RefSeqi WP_011760172.1. NC_008700.1.
    YP_927934.1. NC_008700.1.

    3D structure databases

    ProteinModelPortali A1S7A8.
    SMRi A1S7A8. Positions 5-740.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 326297.Sama_2059.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABM00265 ; ABM00265 ; Sama_2059 .
    GeneIDi 4604309.
    KEGGi saz:Sama_2059.
    PATRICi 23452873. VBISheAma74963_2125.

    Phylogenomic databases

    eggNOGi COG2838.
    HOGENOMi HOG000240860.
    KOi K00031.
    OMAi EEQRIGD.
    OrthoDBi EOG6DVJPP.

    Enzyme and pathway databases

    BioCyci SAMA326297:GH0T-2136-MONOMER.

    Family and domain databases

    Gene3Di 3.40.718.10. 3 hits.
    InterProi IPR004436. Isocitrate_DH_NADP_mono.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    Pfami PF03971. IDH. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF009407. IDH_monmr. 1 hit.
    TIGRFAMsi TIGR00178. monomer_idh. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-1098 / SB2BImported.

    Entry informationi

    Entry nameiA1S7A8_SHEAM
    AccessioniPrimary (citable) accession number: A1S7A8
    Entry historyi
    Integrated into UniProtKB/TrEMBL: February 6, 2007
    Last sequence update: February 6, 2007
    Last modified: October 1, 2014
    This is version 50 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3