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A1S7A8

- A1S7A8_SHEAM

UniProt

A1S7A8 - A1S7A8_SHEAM

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Protein
Submitted name:

Isocitrate dehydrogenase (NADP(+))

Gene

Sama_2059

Organism
Shewanella amazonensis (strain ATCC BAA-1098 / SB2B)
Status
Unreviewed - Annotation score: 2 out of 5- Protein predictedi

Functioni

Cofactori

Binds 1 magnesium or manganese ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei147 – 1471Substrate
Sitei257 – 2571Critical for catalysisUniRule annotation
Metal bindingi352 – 3521Magnesium or manganeseUniRule annotation
Sitei422 – 4221Critical for catalysisUniRule annotation
Binding sitei549 – 5491SubstrateUniRule annotation
Metal bindingi550 – 5501Magnesium or manganeseUniRule annotation
Metal bindingi554 – 5541Magnesium or manganeseUniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseImported

Keywords - Ligandi

MagnesiumUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

BioCyciSAMA326297:GH0T-2136-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Isocitrate dehydrogenase (NADP(+))Imported (EC:1.1.1.42Imported)
Gene namesi
Ordered Locus Names:Sama_2059Imported
OrganismiShewanella amazonensis (strain ATCC BAA-1098 / SB2B)Imported
Taxonomic identifieri326297 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
ProteomesiUP000009175: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi326297.Sama_2059.

Structurei

3D structure databases

ProteinModelPortaliA1S7A8.
SMRiA1S7A8. Positions 5-740.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni134 – 1418Substrate binding

Phylogenomic databases

eggNOGiCOG2838.
HOGENOMiHOG000240860.
KOiK00031.
OMAiEEQRIGD.
OrthoDBiEOG6DVJPP.

Family and domain databases

Gene3Di3.40.718.10. 3 hits.
InterProiIPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PfamiPF03971. IDH. 1 hit.
[Graphical view]
PIRSFiPIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsiTIGR00178. monomer_idh. 1 hit.

Sequencei

Sequence statusi: Complete.

A1S7A8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKDNSPTIIY TETDEAPALA TLSLLPILQT FAEPAGVKIE TRDISLSGRV
60 70 80 90 100
IATFPEKLTD AQRIGDHLAE LGELATKPEA NIIKLPNISA SIPQLKACIK
110 120 130 140 150
ELQAQGYDIP NYPEEPKTDE EKSIKARYDK IKGSAVNPVL REGNSDRRAP
160 170 180 190 200
LSVKNYARKN PHSMGKWASD SKSHVSHMEA GDFYGSEQSV TLADADSVSI
210 220 230 240 250
VHTSKAGVET VLKSGLKLQA GEIIDSAVMS KNALVAFFER EIEAAKAEDV
260 270 280 290 300
LLSLHLKATM MKVSDPIMFG HAVKVFFKPL FAKHAETFER LGVDVNNGFG
310 320 330 340 350
DVVAKIQSLP EAERAAIEAD IQAVYAERPA MAMVNSDKGI TNLHVPSDII
360 370 380 390 400
IDASMPAAIR SSGQMWGPDG QLKDTKFMIP DRCYAGVYDA TINFCKAHGA
410 420 430 440 450
FDPRTMGTIP NVGLMAQKAE EYGSHDKTFE IAEDGVVTVV NAAGSVLMSH
460 470 480 490 500
TVEAGDIFRM CQVKDAPIQD WVKLAVRRAR LSETPAVFWL DKNRAHDAEL
510 520 530 540 550
IKKVEAYLPQ HDTSGLEIHI MSPVEATQFS LARMKDGKDT ISVTGNVLRD
560 570 580 590 600
YLTDLFPILE LGTSAKMLSI VPLMNGGGLF ETGAGGSAPK HVEQVQSENY
610 620 630 640 650
LRWDSLGEFL ALAASFEHLA QTAGVAKAQV LADTLDTAIG KFLDENKSPA
660 670 680 690 700
RRVGQIDNRG SHFYLAMYWA QALAAQTADA ELAAHFGQLA DKLAANEETI
710 720 730 740
LAELIGVQGH SVDLGGYYRP DFAKASAVMR PSATLNGLMS H
Length:741
Mass (Da):80,332
Last modified:February 6, 2007 - v1
Checksum:i0B4691F910BB655C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000507 Genomic DNA. Translation: ABM00265.1.
RefSeqiYP_927934.1. NC_008700.1.

Genome annotation databases

EnsemblBacteriaiABM00265; ABM00265; Sama_2059.
GeneIDi4604309.
KEGGisaz:Sama_2059.
PATRICi23452873. VBISheAma74963_2125.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000507 Genomic DNA. Translation: ABM00265.1 .
RefSeqi YP_927934.1. NC_008700.1.

3D structure databases

ProteinModelPortali A1S7A8.
SMRi A1S7A8. Positions 5-740.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 326297.Sama_2059.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABM00265 ; ABM00265 ; Sama_2059 .
GeneIDi 4604309.
KEGGi saz:Sama_2059.
PATRICi 23452873. VBISheAma74963_2125.

Phylogenomic databases

eggNOGi COG2838.
HOGENOMi HOG000240860.
KOi K00031.
OMAi EEQRIGD.
OrthoDBi EOG6DVJPP.

Enzyme and pathway databases

BioCyci SAMA326297:GH0T-2136-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 3 hits.
InterProi IPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
Pfami PF03971. IDH. 1 hit.
[Graphical view ]
PIRSFi PIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsi TIGR00178. monomer_idh. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-1098 / SB2BImported.

Entry informationi

Entry nameiA1S7A8_SHEAM
AccessioniPrimary (citable) accession number: A1S7A8
Entry historyi
Integrated into UniProtKB/TrEMBL: February 6, 2007
Last sequence update: February 6, 2007
Last modified: October 29, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3