Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Isocitrate dehydrogenase (NADP(+))

Gene

Sama_2059

Organism
Shewanella amazonensis (strain ATCC BAA-1098 / SB2B)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotationNote: Binds 1 Mg(2+) or Mn2+ ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei147 – 1471SubstrateUniRule annotation
Sitei257 – 2571Critical for catalysisUniRule annotation
Metal bindingi352 – 3521Magnesium or manganeseUniRule annotation
Sitei422 – 4221Critical for catalysisUniRule annotation
Binding sitei549 – 5491SubstrateUniRule annotation
Metal bindingi550 – 5501Magnesium or manganeseUniRule annotation
Metal bindingi554 – 5541Magnesium or manganeseUniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseImported

Keywords - Ligandi

MagnesiumUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

BioCyciSAMA326297:GH0T-2136-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Isocitrate dehydrogenase (NADP(+))Imported (EC:1.1.1.42Imported)
Gene namesi
Ordered Locus Names:Sama_2059Imported
OrganismiShewanella amazonensis (strain ATCC BAA-1098 / SB2B)Imported
Taxonomic identifieri326297 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
ProteomesiUP000009175 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi326297.Sama_2059.

Structurei

3D structure databases

ProteinModelPortaliA1S7A8.
SMRiA1S7A8. Positions 5-740.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni134 – 1418Substrate bindingUniRule annotation

Phylogenomic databases

eggNOGiCOG2838.
HOGENOMiHOG000240860.
KOiK00031.
OMAiDENRAHD.
OrthoDBiEOG6DVJPP.

Family and domain databases

Gene3Di3.40.718.10. 3 hits.
InterProiIPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PfamiPF03971. IDH. 1 hit.
[Graphical view]
PIRSFiPIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsiTIGR00178. monomer_idh. 1 hit.

Sequencei

Sequence statusi: Complete.

A1S7A8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKDNSPTIIY TETDEAPALA TLSLLPILQT FAEPAGVKIE TRDISLSGRV
60 70 80 90 100
IATFPEKLTD AQRIGDHLAE LGELATKPEA NIIKLPNISA SIPQLKACIK
110 120 130 140 150
ELQAQGYDIP NYPEEPKTDE EKSIKARYDK IKGSAVNPVL REGNSDRRAP
160 170 180 190 200
LSVKNYARKN PHSMGKWASD SKSHVSHMEA GDFYGSEQSV TLADADSVSI
210 220 230 240 250
VHTSKAGVET VLKSGLKLQA GEIIDSAVMS KNALVAFFER EIEAAKAEDV
260 270 280 290 300
LLSLHLKATM MKVSDPIMFG HAVKVFFKPL FAKHAETFER LGVDVNNGFG
310 320 330 340 350
DVVAKIQSLP EAERAAIEAD IQAVYAERPA MAMVNSDKGI TNLHVPSDII
360 370 380 390 400
IDASMPAAIR SSGQMWGPDG QLKDTKFMIP DRCYAGVYDA TINFCKAHGA
410 420 430 440 450
FDPRTMGTIP NVGLMAQKAE EYGSHDKTFE IAEDGVVTVV NAAGSVLMSH
460 470 480 490 500
TVEAGDIFRM CQVKDAPIQD WVKLAVRRAR LSETPAVFWL DKNRAHDAEL
510 520 530 540 550
IKKVEAYLPQ HDTSGLEIHI MSPVEATQFS LARMKDGKDT ISVTGNVLRD
560 570 580 590 600
YLTDLFPILE LGTSAKMLSI VPLMNGGGLF ETGAGGSAPK HVEQVQSENY
610 620 630 640 650
LRWDSLGEFL ALAASFEHLA QTAGVAKAQV LADTLDTAIG KFLDENKSPA
660 670 680 690 700
RRVGQIDNRG SHFYLAMYWA QALAAQTADA ELAAHFGQLA DKLAANEETI
710 720 730 740
LAELIGVQGH SVDLGGYYRP DFAKASAVMR PSATLNGLMS H
Length:741
Mass (Da):80,332
Last modified:February 6, 2007 - v1
Checksum:i0B4691F910BB655C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000507 Genomic DNA. Translation: ABM00265.1.
RefSeqiWP_011760172.1. NC_008700.1.
YP_927934.1. NC_008700.1.

Genome annotation databases

EnsemblBacteriaiABM00265; ABM00265; Sama_2059.
KEGGisaz:Sama_2059.
PATRICi23452873. VBISheAma74963_2125.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000507 Genomic DNA. Translation: ABM00265.1.
RefSeqiWP_011760172.1. NC_008700.1.
YP_927934.1. NC_008700.1.

3D structure databases

ProteinModelPortaliA1S7A8.
SMRiA1S7A8. Positions 5-740.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi326297.Sama_2059.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABM00265; ABM00265; Sama_2059.
KEGGisaz:Sama_2059.
PATRICi23452873. VBISheAma74963_2125.

Phylogenomic databases

eggNOGiCOG2838.
HOGENOMiHOG000240860.
KOiK00031.
OMAiDENRAHD.
OrthoDBiEOG6DVJPP.

Enzyme and pathway databases

BioCyciSAMA326297:GH0T-2136-MONOMER.

Family and domain databases

Gene3Di3.40.718.10. 3 hits.
InterProiIPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PfamiPF03971. IDH. 1 hit.
[Graphical view]
PIRSFiPIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsiTIGR00178. monomer_idh. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-1098 / SB2BImported.

Entry informationi

Entry nameiA1S7A8_SHEAM
AccessioniPrimary (citable) accession number: A1S7A8
Entry historyi
Integrated into UniProtKB/TrEMBL: February 6, 2007
Last sequence update: February 6, 2007
Last modified: April 1, 2015
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.