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A1S712 (SPEA_SHEAM) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Biosynthetic arginine decarboxylase

Short name=ADC
EC=4.1.1.19
Gene names
Name:speA
Ordered Locus Names:Sama_1963
OrganismShewanella amazonensis (strain ATCC BAA-1098 / SB2B) [Complete proteome] [HAMAP]
Taxonomic identifier326297 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella

Protein attributes

Sequence length636 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the biosynthesis of agmatine from arginine By similarity. HAMAP-Rule MF_01417

Catalytic activity

L-arginine = agmatine + CO2. HAMAP-Rule MF_01417

Cofactor

Magnesium By similarity. HAMAP-Rule MF_01417

Pyridoxal phosphate By similarity. HAMAP-Rule MF_01417

Pathway

Amine and polyamine biosynthesis; agmatine biosynthesis; agmatine from L-arginine: step 1/1. HAMAP-Rule MF_01417

Sequence similarities

Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 636636Biosynthetic arginine decarboxylase HAMAP-Rule MF_01417
PRO_1000024264

Regions

Region286 – 29611Substrate-binding Potential

Amino acid modifications

Modified residue1011N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
A1S712 [UniParc].

Last modified February 6, 2007. Version 1.
Checksum: 1922594751248BA0

FASTA63671,125
        10         20         30         40         50         60 
MNEWSIDDAR AGYNVAHWSQ GFYGISDEGE VTVSPDPKNP TFKIGLNALA KDMVKAGVSL 

        70         80         90        100        110        120 
PVLVRFPQIL HHRVDHLCQM FNQAIQKYEY QSDYLLVYPI KVNQQQTVVE EILASQVSKT 

       130        140        150        160        170        180 
VPQLGLEAGS KPELMAVLAM AQKASSVIVC NGYKDKEYIR LALIGEKLGH SVYIVLEKMS 

       190        200        210        220        230        240 
ELQMVLEESK KLGVTPRLGL RARLAFQGKG KWQASGGEKS KFGLSAAQIL KVVERLKDED 

       250        260        270        280        290        300 
MLESLQLLHF HLGSQIANIR DIRHGVGEAA RFYCELRKLG AKVNCFDVGG GLAVDYDGTR 

       310        320        330        340        350        360 
SQSNNSMNYA LAEYANNIVS VLTDVCNQNE QPMPRIISES GRYLTAHHAV LITDVIGTEA 

       370        380        390        400        410        420 
YSPEDIPAPE EEAPQLLHNM WRSWNEISSR LDQRALIEIF HDTQSDLAEA QSLFALGQLS 

       430        440        450        460        470        480 
LEDRAWAEQC NLAVCHELQG LMNARNRYQR PIIDELNEKL ADRFFVNFSL FQSLPDAWGI 

       490        500        510        520        530        540 
DQVFPVLPLS GLDKVPERRA VMLDITCDSD GIVDQYVDGQ GIETTLPVPN WSAEDPYLIG 

       550        560        570        580        590        600 
FFLVGAYQEI LGDLHNLFGD TNSAVVRIDE EGQTNIESVL AGDTVADVLR YVNLDAVSFM 

       610        620        630 
RTYEELVNSH IAEDERAMIL EELQVGLKGY TYLEDF 

« Hide

References

[1]"Complete sequence of Shewanella amazonensis SB2B."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Munk A.C., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J. expand/collapse author list , Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Fredrickson J., Richardson P.
Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-1098 / SB2B.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000507 Genomic DNA. Translation: ABM00169.1.
RefSeqYP_927838.1. NC_008700.1.

3D structure databases

ProteinModelPortalA1S712.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING326297.Sama_1963.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABM00169; ABM00169; Sama_1963.
GeneID4604213.
KEGGsaz:Sama_1963.
PATRIC23452671. VBISheAma74963_2024.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1166.
HOGENOMHOG000029191.
KOK01585.
OMAMIHFHIG.
OrthoDBEOG676Z0R.
ProtClustDBPRK05354.

Enzyme and pathway databases

BioCycSAMA326297:GH0T-2040-MONOMER.
UniPathwayUPA00186; UER00284.

Family and domain databases

Gene3D2.40.37.10. 2 hits.
HAMAPMF_01417. SpeA.
InterProIPR009006. Ala_racemase/Decarboxylase_C.
IPR002985. Arg_decrbxlase.
IPR022643. De-COase2_C.
IPR022644. De-COase2_N.
IPR000183. Orn/DAP/Arg_de-COase.
[Graphical view]
PfamPF02784. Orn_Arg_deC_N. 1 hit.
PF00278. Orn_DAP_Arg_deC. 1 hit.
[Graphical view]
PIRSFPIRSF001336. Arg_decrbxlase. 1 hit.
PRINTSPR01180. ARGDCRBXLASE.
PR01179. ODADCRBXLASE.
TIGRFAMsTIGR01273. speA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameSPEA_SHEAM
AccessionPrimary (citable) accession number: A1S712
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 6, 2007
Last modified: February 19, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways