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A1S712

- SPEA_SHEAM

UniProt

A1S712 - SPEA_SHEAM

Protein

Biosynthetic arginine decarboxylase

Gene

speA

Organism
Shewanella amazonensis (strain ATCC BAA-1098 / SB2B)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 53 (01 Oct 2014)
      Sequence version 1 (06 Feb 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the biosynthesis of agmatine from arginine.UniRule annotation

    Catalytic activityi

    L-arginine = agmatine + CO2.UniRule annotation

    Cofactori

    Magnesium.UniRule annotation
    Pyridoxal phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. arginine decarboxylase activity Source: UniProtKB-HAMAP
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. arginine catabolic process Source: InterPro
    2. spermidine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Decarboxylase, Lyase

    Keywords - Biological processi

    Polyamine biosynthesis, Spermidine biosynthesis

    Keywords - Ligandi

    Magnesium, Metal-binding, Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciSAMA326297:GH0T-2040-MONOMER.
    UniPathwayiUPA00186; UER00284.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Biosynthetic arginine decarboxylaseUniRule annotation (EC:4.1.1.19UniRule annotation)
    Short name:
    ADCUniRule annotation
    Gene namesi
    Name:speAUniRule annotation
    Ordered Locus Names:Sama_1963
    OrganismiShewanella amazonensis (strain ATCC BAA-1098 / SB2B)
    Taxonomic identifieri326297 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
    ProteomesiUP000009175: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 636636Biosynthetic arginine decarboxylasePRO_1000024264Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei101 – 1011N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Protein-protein interaction databases

    STRINGi326297.Sama_1963.

    Structurei

    3D structure databases

    ProteinModelPortaliA1S712.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni286 – 29611Substrate-bindingUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1166.
    HOGENOMiHOG000029191.
    KOiK01585.
    OMAiIDHYVDG.
    OrthoDBiEOG676Z0R.

    Family and domain databases

    Gene3Di2.40.37.10. 2 hits.
    3.20.20.10. 1 hit.
    HAMAPiMF_01417. SpeA.
    InterProiIPR009006. Ala_racemase/Decarboxylase_C.
    IPR002985. Arg_decrbxlase.
    IPR022643. De-COase2_C.
    IPR022644. De-COase2_N.
    IPR000183. Orn/DAP/Arg_de-COase.
    IPR029066. PLP-binding_barrel.
    [Graphical view]
    PfamiPF02784. Orn_Arg_deC_N. 1 hit.
    PF00278. Orn_DAP_Arg_deC. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001336. Arg_decrbxlase. 1 hit.
    PRINTSiPR01180. ARGDCRBXLASE.
    PR01179. ODADCRBXLASE.
    SUPFAMiSSF51419. SSF51419. 1 hit.
    TIGRFAMsiTIGR01273. speA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A1S712-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNEWSIDDAR AGYNVAHWSQ GFYGISDEGE VTVSPDPKNP TFKIGLNALA    50
    KDMVKAGVSL PVLVRFPQIL HHRVDHLCQM FNQAIQKYEY QSDYLLVYPI 100
    KVNQQQTVVE EILASQVSKT VPQLGLEAGS KPELMAVLAM AQKASSVIVC 150
    NGYKDKEYIR LALIGEKLGH SVYIVLEKMS ELQMVLEESK KLGVTPRLGL 200
    RARLAFQGKG KWQASGGEKS KFGLSAAQIL KVVERLKDED MLESLQLLHF 250
    HLGSQIANIR DIRHGVGEAA RFYCELRKLG AKVNCFDVGG GLAVDYDGTR 300
    SQSNNSMNYA LAEYANNIVS VLTDVCNQNE QPMPRIISES GRYLTAHHAV 350
    LITDVIGTEA YSPEDIPAPE EEAPQLLHNM WRSWNEISSR LDQRALIEIF 400
    HDTQSDLAEA QSLFALGQLS LEDRAWAEQC NLAVCHELQG LMNARNRYQR 450
    PIIDELNEKL ADRFFVNFSL FQSLPDAWGI DQVFPVLPLS GLDKVPERRA 500
    VMLDITCDSD GIVDQYVDGQ GIETTLPVPN WSAEDPYLIG FFLVGAYQEI 550
    LGDLHNLFGD TNSAVVRIDE EGQTNIESVL AGDTVADVLR YVNLDAVSFM 600
    RTYEELVNSH IAEDERAMIL EELQVGLKGY TYLEDF 636
    Length:636
    Mass (Da):71,125
    Last modified:February 6, 2007 - v1
    Checksum:i1922594751248BA0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000507 Genomic DNA. Translation: ABM00169.1.
    RefSeqiYP_927838.1. NC_008700.1.

    Genome annotation databases

    EnsemblBacteriaiABM00169; ABM00169; Sama_1963.
    GeneIDi4604213.
    KEGGisaz:Sama_1963.
    PATRICi23452671. VBISheAma74963_2024.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000507 Genomic DNA. Translation: ABM00169.1 .
    RefSeqi YP_927838.1. NC_008700.1.

    3D structure databases

    ProteinModelPortali A1S712.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 326297.Sama_1963.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABM00169 ; ABM00169 ; Sama_1963 .
    GeneIDi 4604213.
    KEGGi saz:Sama_1963.
    PATRICi 23452671. VBISheAma74963_2024.

    Phylogenomic databases

    eggNOGi COG1166.
    HOGENOMi HOG000029191.
    KOi K01585.
    OMAi IDHYVDG.
    OrthoDBi EOG676Z0R.

    Enzyme and pathway databases

    UniPathwayi UPA00186 ; UER00284 .
    BioCyci SAMA326297:GH0T-2040-MONOMER.

    Family and domain databases

    Gene3Di 2.40.37.10. 2 hits.
    3.20.20.10. 1 hit.
    HAMAPi MF_01417. SpeA.
    InterProi IPR009006. Ala_racemase/Decarboxylase_C.
    IPR002985. Arg_decrbxlase.
    IPR022643. De-COase2_C.
    IPR022644. De-COase2_N.
    IPR000183. Orn/DAP/Arg_de-COase.
    IPR029066. PLP-binding_barrel.
    [Graphical view ]
    Pfami PF02784. Orn_Arg_deC_N. 1 hit.
    PF00278. Orn_DAP_Arg_deC. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001336. Arg_decrbxlase. 1 hit.
    PRINTSi PR01180. ARGDCRBXLASE.
    PR01179. ODADCRBXLASE.
    SUPFAMi SSF51419. SSF51419. 1 hit.
    TIGRFAMsi TIGR01273. speA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-1098 / SB2B.

    Entry informationi

    Entry nameiSPEA_SHEAM
    AccessioniPrimary (citable) accession number: A1S712
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: February 6, 2007
    Last modified: October 1, 2014
    This is version 53 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3