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A1S4U5

- GH109_SHEAM

UniProt

A1S4U5 - GH109_SHEAM

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Protein

Glycosyl hydrolase family 109 protein

Gene

Sama_1194

Organism
Shewanella amazonensis (strain ATCC BAA-1098 / SB2B)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Glycosidase.By similarity

Cofactori

Binds 1 NAD+ per subunit. The NAD cannot dissociate By similarity.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei84 – 841NADBy similarity
Binding sitei112 – 1121NAD; via carbonyl oxygenBy similarity
Binding sitei182 – 1821NADBy similarity
Binding sitei211 – 2111SubstrateBy similarity
Binding sitei230 – 2301SubstrateBy similarity
Binding sitei242 – 2421NADBy similarity
Binding sitei324 – 3241SubstrateBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi62 – 632NADBy similarity
Nucleotide bindingi133 – 1364NADBy similarity
Nucleotide bindingi153 – 1542NADBy similarity

GO - Molecular functioni

  1. hydrolase activity, acting on glycosyl bonds Source: UniProtKB-KW
  2. oxidoreductase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciSAMA326297:GH0T-1238-MONOMER.

Protein family/group databases

CAZyiGH109. Glycoside Hydrolase Family 109.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycosyl hydrolase family 109 protein (EC:3.2.1.-)
Gene namesi
Ordered Locus Names:Sama_1194
OrganismiShewanella amazonensis (strain ATCC BAA-1098 / SB2B)
Taxonomic identifieri326297 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
ProteomesiUP000009175: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3333Tat-type signalPROSITE-ProRule annotationAdd
BLAST
Chaini34 – 455422Glycosyl hydrolase family 109 proteinPRO_5000205145Add
BLAST

Post-translational modificationi

Predicted to be exported by the Tat system. The position of the signal peptide cleavage has not been experimentally proven.

Interactioni

Protein-protein interaction databases

STRINGi326297.Sama_1194.

Structurei

3D structure databases

ProteinModelPortaliA1S4U5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni242 – 2454Substrate bindingBy similarity

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG0673.
HOGENOMiHOG000252553.
OMAiCYGRDEL.
OrthoDBiEOG61P6MK.

Family and domain databases

Gene3Di3.40.50.720. 2 hits.
InterProiIPR016040. NAD(P)-bd_dom.
IPR000683. Oxidoreductase_N.
IPR006311. TAT_signal.
IPR019546. TAT_signal_bac_arc.
[Graphical view]
PfamiPF01408. GFO_IDH_MocA. 1 hit.
PF10518. TAT_signal. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01409. TAT_signal_seq. 1 hit.
PROSITEiPS51318. TAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A1S4U5-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MAGIDRRGFL KASMASVAAA ALAGCASQQG TSATPKAAGK SVMGLVVPKM
60 70 80 90 100
AEVRVGLIGV GERGVGFIHH FNNIEGARIT AICDTDPLVI SRAQKIMADY
110 120 130 140 150
GRSQPAYYSK GQQAYLDLVA REDVDIVVIA TPWALHHPMA KAAMLAGKHA
160 170 180 190 200
FVEVPMGMTI EELWDLVDTA ELTQRNCMMM ENVCYGRDEL MVLNMVRQGL
210 220 230 240 250
FGELLHGEAA YIHELRWQMK ELDRKTGSWR TGYHAQINGN LYPTHGLGPV
260 270 280 290 300
AQYMNINRGD RFDYLSSMSS PALGRAAYAQ REFPKDHQRN QLNYICGDMN
310 320 330 340 350
TSLIKTVKGR TIMVQHDTTT PRPYSRHNLI QGTNGVFAGF PNRIALENHG
360 370 380 390 400
RGSFHEWDQD MEHWYGKYDH PLWTRMGREA EQNGGHGGMD FLMCWRMIYC
410 420 430 440 450
LRNGEPLDQD VYDGAAWSAV QPLSAASVAD RGNSRDFPDF TRGVWQSATP

LGIVE
Length:455
Mass (Da):50,618
Last modified:February 6, 2007 - v1
Checksum:i420B511BBCB00967
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000507 Genomic DNA. Translation: ABL99401.1.
RefSeqiWP_011759310.1. NC_008700.1.
YP_927071.1. NC_008700.1.

Genome annotation databases

EnsemblBacteriaiABL99401; ABL99401; Sama_1194.
GeneIDi4603446.
KEGGisaz:Sama_1194.
PATRICi23451027. VBISheAma74963_1234.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000507 Genomic DNA. Translation: ABL99401.1 .
RefSeqi WP_011759310.1. NC_008700.1.
YP_927071.1. NC_008700.1.

3D structure databases

ProteinModelPortali A1S4U5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 326297.Sama_1194.

Protein family/group databases

CAZyi GH109. Glycoside Hydrolase Family 109.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABL99401 ; ABL99401 ; Sama_1194 .
GeneIDi 4603446.
KEGGi saz:Sama_1194.
PATRICi 23451027. VBISheAma74963_1234.

Phylogenomic databases

eggNOGi COG0673.
HOGENOMi HOG000252553.
OMAi CYGRDEL.
OrthoDBi EOG61P6MK.

Enzyme and pathway databases

BioCyci SAMA326297:GH0T-1238-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 2 hits.
InterProi IPR016040. NAD(P)-bd_dom.
IPR000683. Oxidoreductase_N.
IPR006311. TAT_signal.
IPR019546. TAT_signal_bac_arc.
[Graphical view ]
Pfami PF01408. GFO_IDH_MocA. 1 hit.
PF10518. TAT_signal. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR01409. TAT_signal_seq. 1 hit.
PROSITEi PS51318. TAT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-1098 / SB2B.

Entry informationi

Entry nameiGH109_SHEAM
AccessioniPrimary (citable) accession number: A1S4U5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: February 6, 2007
Last modified: October 1, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3