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A1S4Q3

- LPXB_SHEAM

UniProt

A1S4Q3 - LPXB_SHEAM

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Protein
Lipid-A-disaccharide synthase
Gene
lpxB, Sama_1152
Organism
Shewanella amazonensis (strain ATCC BAA-1098 / SB2B)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity.UniRule annotation

Catalytic activityi

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciSAMA326297:GH0T-1196-MONOMER.
UniPathwayiUPA00359; UER00481.

Protein family/group databases

CAZyiGT19. Glycosyltransferase Family 19.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid-A-disaccharide synthase (EC:2.4.1.182)
Gene namesi
Name:lpxB
Ordered Locus Names:Sama_1152
OrganismiShewanella amazonensis (strain ATCC BAA-1098 / SB2B)
Taxonomic identifieri326297 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
ProteomesiUP000009175: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 393393Lipid-A-disaccharide synthaseUniRule annotation
PRO_1000049414Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi326297.Sama_1152.

Structurei

3D structure databases

ProteinModelPortaliA1S4Q3.

Family & Domainsi

Sequence similaritiesi

Belongs to the LpxB family.

Phylogenomic databases

eggNOGiCOG0763.
HOGENOMiHOG000018003.
KOiK00748.
OMAiVSPITYR.
OrthoDBiEOG6FBWZR.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
[Graphical view]
PfamiPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00215. lpxB. 1 hit.

Sequencei

Sequence statusi: Complete.

A1S4Q3-1 [UniParc]FASTAAdd to Basket

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MSQSKPLVFA MVAGELSGDI LGAGLVKALK ARHPDARFVG IGGPRMEALG    50
FESLFAMEEL AVMGIVEVLS RLPRLLKVRS SLVSQLLALK PDCFIGIDAP 100
DFNIGVELKL KQQGIKTVHY VSPSVWAWRP KRIFKIAKAT NMVLSLLPFE 150
KAFYDQHQVP CTFVGHTLAD DIPLELSKAD ARETLGLDRD AEYLAILPGS 200
RGGELKMLSE PFIKAAVAIK EALPDVRFIT PLVNEKRREQ FLTALETHAP 250
GLEIQLFDGQ SREIMAASDG ILLASGTATL EAMLVKRPMV VAYRVAPLTY 300
SIASRMMLIK RYSLPNLLSG KDLVPELIQA DCTPQKIASE VVAMMNRDNR 350
ALIAEFTEMH QNLRQNASER AADAVDVLIG ANAPHGRSSN EVG 393
Length:393
Mass (Da):42,993
Last modified:February 6, 2007 - v1
Checksum:i98C41E8604C482EB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000507 Genomic DNA. Translation: ABL99359.1.
RefSeqiWP_011759268.1. NC_008700.1.
YP_927029.1. NC_008700.1.

Genome annotation databases

EnsemblBacteriaiABL99359; ABL99359; Sama_1152.
GeneIDi4603404.
KEGGisaz:Sama_1152.
PATRICi23450941. VBISheAma74963_1191.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000507 Genomic DNA. Translation: ABL99359.1 .
RefSeqi WP_011759268.1. NC_008700.1.
YP_927029.1. NC_008700.1.

3D structure databases

ProteinModelPortali A1S4Q3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 326297.Sama_1152.

Protein family/group databases

CAZyi GT19. Glycosyltransferase Family 19.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABL99359 ; ABL99359 ; Sama_1152 .
GeneIDi 4603404.
KEGGi saz:Sama_1152.
PATRICi 23450941. VBISheAma74963_1191.

Phylogenomic databases

eggNOGi COG0763.
HOGENOMi HOG000018003.
KOi K00748.
OMAi VSPITYR.
OrthoDBi EOG6FBWZR.

Enzyme and pathway databases

UniPathwayi UPA00359 ; UER00481 .
BioCyci SAMA326297:GH0T-1196-MONOMER.

Family and domain databases

HAMAPi MF_00392. LpxB.
InterProi IPR003835. Glyco_trans_19.
[Graphical view ]
Pfami PF02684. LpxB. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00215. lpxB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-1098 / SB2B.

Entry informationi

Entry nameiLPXB_SHEAM
AccessioniPrimary (citable) accession number: A1S4Q3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 6, 2007
Last modified: September 3, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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