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Protein

Protein-L-isoaspartate O-methyltransferase

Gene

pcm

Organism
Shewanella amazonensis (strain ATCC BAA-1098 / SB2B)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + protein L-isoaspartate = S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei62UniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionMethyltransferase, Transferase
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciSAMA326297:G1G7Q-1095-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein-L-isoaspartate O-methyltransferaseUniRule annotation (EC:2.1.1.77UniRule annotation)
Alternative name(s):
L-isoaspartyl protein carboxyl methyltransferaseUniRule annotation
Protein L-isoaspartyl methyltransferaseUniRule annotation
Protein-beta-aspartate methyltransferaseUniRule annotation
Short name:
PIMTUniRule annotation
Gene namesi
Name:pcmUniRule annotation
Ordered Locus Names:Sama_1042
OrganismiShewanella amazonensis (strain ATCC BAA-1098 / SB2B)
Taxonomic identifieri326297 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
Proteomesi
  • UP000009175 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000932791 – 211Protein-L-isoaspartate O-methyltransferaseAdd BLAST211

Interactioni

Protein-protein interaction databases

STRINGi326297.Sama_1042.

Structurei

3D structure databases

ProteinModelPortaliA1S4E3.
SMRiA1S4E3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105E26. Bacteria.
COG2518. LUCA.
HOGENOMiHOG000257189.
KOiK00573.
OMAiPYTVAFQ.
OrthoDBiPOG091H06AY.

Family and domain databases

HAMAPiMF_00090. PIMT. 1 hit.
InterProiView protein in InterPro
IPR000682. PCMT.
IPR029063. SAM-dependent_MTases.
PANTHERiPTHR11579. PTHR11579. 1 hit.
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00080. pimt. 1 hit.
PROSITEiView protein in PROSITE
PS01279. PCMT. 1 hit.

Sequencei

Sequence statusi: Complete.

A1S4E3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNQTGSTVAI NLAKKLYDAG IRDNLVLQAI ANTPREMFLD AALAHKAYEN
60 70 80 90 100
TALPIGQGQT ISQPYIVARM TELVMQNRPQ RVLEVGTGSG YQAAILAKLV
110 120 130 140 150
PELCTIERIK ALQIQARQRL KRLDLHNVSF KYGDGWLGWP NRGPFDAIMV
160 170 180 190 200
TAAAASLPTA LLEQLSEGGR LIIPVGEDAQ QLLAITRKGQ EYSSEVIESV
210
KFVPLVNGNL A
Length:211
Mass (Da):23,022
Last modified:February 6, 2007 - v1
Checksum:i566A27A9226ADE57
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000507 Genomic DNA. Translation: ABL99249.1.
RefSeqiWP_011759158.1. NC_008700.1.

Genome annotation databases

EnsemblBacteriaiABL99249; ABL99249; Sama_1042.
KEGGisaz:Sama_1042.

Similar proteinsi

Entry informationi

Entry nameiPIMT_SHEAM
AccessioniPrimary (citable) accession number: A1S4E3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: February 6, 2007
Last modified: February 28, 2018
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome