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A1S462

- IF2_SHEAM

UniProt

A1S462 - IF2_SHEAM

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Protein

Translation initiation factor IF-2

Gene

infB

Organism
Shewanella amazonensis (strain ATCC BAA-1098 / SB2B)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi391 – 3988GTPUniRule annotation
Nucleotide bindingi437 – 4415GTPUniRule annotation
Nucleotide bindingi491 – 4944GTPUniRule annotation

GO - Molecular functioni

  1. GTPase activity Source: UniProtKB-HAMAP
  2. GTP binding Source: UniProtKB-KW
  3. translation initiation factor activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSAMA326297:GH0T-996-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Translation initiation factor IF-2UniRule annotation
Gene namesi
Name:infBUniRule annotation
Ordered Locus Names:Sama_0961
OrganismiShewanella amazonensis (strain ATCC BAA-1098 / SB2B)
Taxonomic identifieri326297 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
ProteomesiUP000009175: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 882882Translation initiation factor IF-2PRO_1000008327Add
BLAST

Proteomic databases

PRIDEiA1S462.

Interactioni

Protein-protein interaction databases

STRINGi326297.Sama_0961.

Structurei

3D structure databases

ProteinModelPortaliA1S462.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini382 – 551170tr-type GAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni391 – 3988G1By similarity
Regioni416 – 4205G2By similarity
Regioni437 – 4404G3By similarity
Regioni491 – 4944G4By similarity
Regioni527 – 5293G5By similarity

Sequence similaritiesi

Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0532.
HOGENOMiHOG000076907.
KOiK02519.
OMAiNFECGLS.
OrthoDBiEOG67HJSV.

Family and domain databases

Gene3Di3.40.50.10050. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00100_B. IF_2_B.
InterProiIPR009061. DNA-bd_dom_put.
IPR000795. EF_GTP-bd_dom.
IPR013575. IF2_assoc_dom_bac.
IPR006847. IF2_N.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000178. TF_IF2_bacterial-like.
IPR015760. TIF_IF2.
IPR023115. TIF_IF2_dom3.
IPR009000. Transl_B-barrel.
IPR004161. Transl_elong_EFTu/EF1A_2.
[Graphical view]
PANTHERiPTHR23115:SF41. PTHR23115:SF41. 1 hit.
PfamiPF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 2 hits.
PF11987. IF-2. 1 hit.
PF08364. IF2_assoc. 1 hit.
PF04760. IF2_N. 2 hits.
[Graphical view]
SUPFAMiSSF46955. SSF46955. 1 hit.
SSF50447. SSF50447. 2 hits.
SSF52156. SSF52156. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00487. IF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS51722. G_TR_2. 1 hit.
PS01176. IF2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1S462-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTEITVEKLA TEVGKTVDRL IEQFAQAGIK KAKADTVSES EKQQLLDFLK
60 70 80 90 100
KQHGADAQPT KMTLQRKTVS TLSVSSGGGQ SKDVKVEVRK KRTFVKRDGN
110 120 130 140 150
EAALKAEEEA RAQAEAQAKA EAEAKAKAEA EAKAKADAEA KAKAKAEAEA
160 170 180 190 200
KAKASASAAK EQPKPVESEE AKAEAARLKS QQEEAAKSKA AQEEAAAKEK
210 220 230 240 250
ARLLAEENAA RWAEEERRRI EAERYGDHHV TTSKVARAAE DSADLDDEKR
260 270 280 290 300
GRRNRNKTQT KSKRGGKDAR EGREKHMKYK STPESMAHGF NKPVAAVTRD
310 320 330 340 350
VRIGETVTVA ELAQKMAVKA TEIIKAMMKM GSMVTINQVL DQETAQLVAE
360 370 380 390 400
EMGHKVVLLR ENELEHQVLA DRDDEGTTKL EPRAPVVTIM GHVDHGKTSL
410 420 430 440 450
LDYIRRTKVA AGEAGGITQH IGAYHVETDN GMITFLDTPG HAAFTAMRAR
460 470 480 490 500
GAKATDIVIL VVAADDGVMP QTIEAIQHAK AGNVPLIVAV NKMDKPEADI
510 520 530 540 550
DRVKNELSQH GVMSEDWGGE NMFCYVSAKT GQGVDELLEA ILLQAEVLEL
560 570 580 590 600
KAVRDGMAAG VVIESQLDKG RGPVATVLVQ EGTLRQGDIV LCGLEYGKIR
610 620 630 640 650
AMKDENGRPI MEAGPSIPVE ILGLSGVPSA GDEATVVRDE RKAREVALYR
660 670 680 690 700
QGKFRDVKLA RQQKSKLENM FANMTEGEVQ ELNIVLKADV QGSLEAITDS
710 720 730 740 750
LRKLSTDEVK VNIIASGVGA LTETDATLAA ASNAIMVGFN VRADAQARKT
760 770 780 790 800
IESEAVDLRY YSVIYDLIDE VKSAMSGMLS PEFKQQIIGL AEVRDVFKSP
810 820 830 840 850
KLGAIAGCMV IEGIVKRSAP IRVLRENVVI YEGELESLRR FKDDVNEVRN
860 870 880
GMECGIGVKN YNDVRVGDQI EVFETIEVAR TL
Length:882
Mass (Da):95,960
Last modified:February 6, 2007 - v1
Checksum:iFBB2AA4E6C2155CF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000507 Genomic DNA. Translation: ABL99168.1.
RefSeqiYP_926838.1. NC_008700.1.

Genome annotation databases

EnsemblBacteriaiABL99168; ABL99168; Sama_0961.
GeneIDi4603213.
KEGGisaz:Sama_0961.
PATRICi23450535. VBISheAma74963_0996.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000507 Genomic DNA. Translation: ABL99168.1 .
RefSeqi YP_926838.1. NC_008700.1.

3D structure databases

ProteinModelPortali A1S462.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 326297.Sama_0961.

Proteomic databases

PRIDEi A1S462.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABL99168 ; ABL99168 ; Sama_0961 .
GeneIDi 4603213.
KEGGi saz:Sama_0961.
PATRICi 23450535. VBISheAma74963_0996.

Phylogenomic databases

eggNOGi COG0532.
HOGENOMi HOG000076907.
KOi K02519.
OMAi NFECGLS.
OrthoDBi EOG67HJSV.

Enzyme and pathway databases

BioCyci SAMA326297:GH0T-996-MONOMER.

Family and domain databases

Gene3Di 3.40.50.10050. 1 hit.
3.40.50.300. 1 hit.
HAMAPi MF_00100_B. IF_2_B.
InterProi IPR009061. DNA-bd_dom_put.
IPR000795. EF_GTP-bd_dom.
IPR013575. IF2_assoc_dom_bac.
IPR006847. IF2_N.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000178. TF_IF2_bacterial-like.
IPR015760. TIF_IF2.
IPR023115. TIF_IF2_dom3.
IPR009000. Transl_B-barrel.
IPR004161. Transl_elong_EFTu/EF1A_2.
[Graphical view ]
PANTHERi PTHR23115:SF41. PTHR23115:SF41. 1 hit.
Pfami PF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 2 hits.
PF11987. IF-2. 1 hit.
PF08364. IF2_assoc. 1 hit.
PF04760. IF2_N. 2 hits.
[Graphical view ]
SUPFAMi SSF46955. SSF46955. 1 hit.
SSF50447. SSF50447. 2 hits.
SSF52156. SSF52156. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00487. IF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEi PS51722. G_TR_2. 1 hit.
PS01176. IF2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-1098 / SB2B.

Entry informationi

Entry nameiIF2_SHEAM
AccessioniPrimary (citable) accession number: A1S462
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 6, 2007
Last modified: October 29, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3