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A1S3T2

- UPPP_SHEAM

UniProt

A1S3T2 - UPPP_SHEAM

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Protein

Undecaprenyl-diphosphatase

Gene

uppP

Organism
Shewanella amazonensis (strain ATCC BAA-1098 / SB2B)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

Catalytic activityi

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

GO - Molecular functioni

  1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. cell wall organization Source: UniProtKB-KW
  2. dephosphorylation Source: InterPro
  3. peptidoglycan biosynthetic process Source: UniProtKB-KW
  4. regulation of cell shape Source: UniProtKB-KW
  5. response to antibiotic Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciSAMA326297:GH0T-862-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl-diphosphataseUniRule annotation (EC:3.6.1.27UniRule annotation)
Alternative name(s):
Bacitracin resistance proteinUniRule annotation
Undecaprenyl pyrophosphate phosphataseUniRule annotation
Gene namesi
Name:uppPUniRule annotation
Ordered Locus Names:Sama_0831
OrganismiShewanella amazonensis (strain ATCC BAA-1098 / SB2B)
Taxonomic identifieri326297 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
ProteomesiUP000009175: Chromosome

Subcellular locationi

Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei1 – 2121HelicalUniRule annotationAdd
BLAST
Transmembranei39 – 5921HelicalUniRule annotationAdd
BLAST
Transmembranei83 – 10321HelicalUniRule annotationAdd
BLAST
Transmembranei111 – 13121HelicalUniRule annotationAdd
BLAST
Transmembranei149 – 16921HelicalUniRule annotationAdd
BLAST
Transmembranei183 – 20321HelicalUniRule annotationAdd
BLAST
Transmembranei218 – 23821HelicalUniRule annotationAdd
BLAST
Transmembranei246 – 26621HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 266266Undecaprenyl-diphosphatasePRO_0000290760Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi326297.Sama_0831.

Structurei

3D structure databases

ProteinModelPortaliA1S3T2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UppP family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1968.
HOGENOMiHOG000218357.
KOiK06153.
OMAiVIYFRNE.
OrthoDBiEOG6QP13M.

Family and domain databases

HAMAPiMF_01006. Undec_diphosphatase.
InterProiIPR003824. UppP.
[Graphical view]
PfamiPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00753. undec_PP_bacA. 1 hit.

Sequencei

Sequence statusi: Complete.

A1S3T2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDTLQVIILA LIQGLTEFLP ISSSAHLILP AQLFGWEDQG LSFDVAVHIG
60 70 80 90 100
SLAAVVIYFR NEILAMLKAW LASIFRGQQS DDSKLAWWII LATIPAIGVG
110 120 130 140 150
FTAKDMVETH LRGPGVIAIT TVIFGLLLWF ADRIAKDEMT EYQTGWRKAL
160 170 180 190 200
LIGVAQALAL IPGTSRSGIT ITAALMLGLK REAAARFSFL MSIPVILGAA
210 220 230 240 250
LLMTKDIITE NHVVDWHALA LGSILSFIAA YACIYFFLKI ISRMGMTPFV
260
IYRIALGVFL CGFIYL
Length:266
Mass (Da):29,150
Last modified:February 6, 2007 - v1
Checksum:i97F2018519BC2A6A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000507 Genomic DNA. Translation: ABL99038.1.
RefSeqiWP_011758948.1. NC_008700.1.
YP_926708.1. NC_008700.1.

Genome annotation databases

EnsemblBacteriaiABL99038; ABL99038; Sama_0831.
GeneIDi4603083.
KEGGisaz:Sama_0831.
PATRICi23450265. VBISheAma74963_0865.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000507 Genomic DNA. Translation: ABL99038.1 .
RefSeqi WP_011758948.1. NC_008700.1.
YP_926708.1. NC_008700.1.

3D structure databases

ProteinModelPortali A1S3T2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 326297.Sama_0831.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABL99038 ; ABL99038 ; Sama_0831 .
GeneIDi 4603083.
KEGGi saz:Sama_0831.
PATRICi 23450265. VBISheAma74963_0865.

Phylogenomic databases

eggNOGi COG1968.
HOGENOMi HOG000218357.
KOi K06153.
OMAi VIYFRNE.
OrthoDBi EOG6QP13M.

Enzyme and pathway databases

BioCyci SAMA326297:GH0T-862-MONOMER.

Family and domain databases

HAMAPi MF_01006. Undec_diphosphatase.
InterProi IPR003824. UppP.
[Graphical view ]
Pfami PF02673. BacA. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00753. undec_PP_bacA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-1098 / SB2B.

Entry informationi

Entry nameiUPPP_SHEAM
AccessioniPrimary (citable) accession number: A1S3T2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: February 6, 2007
Last modified: October 29, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3