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Protein

Catalase-peroxidase 2

Gene

katG2

Organism
Shewanella amazonensis (strain ATCC BAA-1098 / SB2B)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.UniRule annotation

Catalytic activityi

Donor + H2O2 = oxidized donor + 2 H2O.UniRule annotation
2 H2O2 = O2 + 2 H2O.UniRule annotation

Cofactori

heme bUniRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei101 – 1011Transition state stabilizerUniRule annotation
Active sitei105 – 1051Proton acceptorUniRule annotation
Metal bindingi267 – 2671Iron (heme axial ligand)UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxide

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciSAMA326297:GH0T-775-MONOMER.

Protein family/group databases

PeroxiBasei3598. SamCP01_SB2B.

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase-peroxidase 2UniRule annotation (EC:1.11.1.21UniRule annotation)
Short name:
CP 2UniRule annotation
Alternative name(s):
Peroxidase/catalase 2UniRule annotation
Gene namesi
Name:katG2UniRule annotation
Ordered Locus Names:Sama_0745
OrganismiShewanella amazonensis (strain ATCC BAA-1098 / SB2B)
Taxonomic identifieri326297 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
Proteomesi
  • UP000009175 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626UniRule annotationAdd
BLAST
Chaini27 – 738712Catalase-peroxidase 2PRO_5000205037Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki104 ↔ 226Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-252)UniRule annotation
Cross-linki226 ↔ 252Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-104)UniRule annotation

Post-translational modificationi

The covalent Trp-Tyr-Met adduct is important for the catalase, but not the peroxidase activity of the enzyme.UniRule annotation

Proteomic databases

PRIDEiA1S3J7.

Interactioni

Subunit structurei

Homodimer or homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi326297.Sama_0745.

Structurei

3D structure databases

ProteinModelPortaliA1S3J7.
SMRiA1S3J7. Positions 30-738.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Peroxidase/catalase subfamily.UniRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4105C1X. Bacteria.
COG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OMAiMSTRWEK.
OrthoDBiPOG091H05R1.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A1S3J7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKRTLPTLSA LALSMSLALA AGQTQAAETT TNSYWWPEQL DLSPLRQHGS
60 70 80 90 100
ESNPYGADYD YAKAFGSLDL VAVKADIKTV LTTSQDWWPA DYGHYGPFFI
110 120 130 140 150
RMAWHSAGVY RIFDGRGGAS GGQQRFEPLN SWPDNVNLDK ARRLLWPIKQ
160 170 180 190 200
KYGSKISWAD LMVLAGNVSL ESMGFKTFGF AGGRTDDWEA ERVDWGHEKK
210 220 230 240 250
WLDNKRHNEK GELAKPLGAT QMGLIYVNPE GPNGVPDPLA AARDIRETFG
260 270 280 290 300
RMAMNDEETV ALIAGGHTFG KAHGAHDPAK CVGADPAAAG VEAQGLGWKN
310 320 330 340 350
KCGKGHSEDT VTSGLEGAWS VSPTQWTMQY LDNLYGFEWV QSKSPAGHIQ
360 370 380 390 400
WIPANGAGDN LVPDAHVAGK RHAPIMFTTD IALKEDPSYR EITSRFRKDP
410 420 430 440 450
KAFELAFAKA WFKLTHRDMG PKTRYLGSDV PAEALIWQDP IPALDHAVID
460 470 480 490 500
TNDIAALKSA ILASGIAVPE LVRTAWASAA SFRGTDMRGG ANGARLRLEP
510 520 530 540 550
QRSWEVNNPE ELAKVLPKLE KIQKDFNKSL KGGKKVSLAD VIVLAGGTAI
560 570 580 590 600
EQAARSAGYS VTVPFTPGRM DATTAQTDVS SFAVLEPKAD AFRNFFSEES
610 620 630 640 650
YLPPAEALVE KATQLTLSVP EMTALVGGLR VLDANSNKAK HGVFTDKPGN
660 670 680 690 700
LSNDFFVNLL DMSTRWEKSP REAGLYQGFD RQSGKLRWTA TPVDLIFGSH
710 720 730
AELRAVAEVY GANDGKDRFV EDFIAAWTKV MNLDRFDI
Length:738
Mass (Da):80,792
Last modified:February 6, 2007 - v1
Checksum:i16A56208A6DDEC69
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000507 Genomic DNA. Translation: ABL98953.1.
RefSeqiWP_011758863.1. NC_008700.1.

Genome annotation databases

EnsemblBacteriaiABL98953; ABL98953; Sama_0745.
KEGGisaz:Sama_0745.
PATRICi23450081. VBISheAma74963_0774.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000507 Genomic DNA. Translation: ABL98953.1.
RefSeqiWP_011758863.1. NC_008700.1.

3D structure databases

ProteinModelPortaliA1S3J7.
SMRiA1S3J7. Positions 30-738.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi326297.Sama_0745.

Protein family/group databases

PeroxiBasei3598. SamCP01_SB2B.

Proteomic databases

PRIDEiA1S3J7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABL98953; ABL98953; Sama_0745.
KEGGisaz:Sama_0745.
PATRICi23450081. VBISheAma74963_0774.

Phylogenomic databases

eggNOGiENOG4105C1X. Bacteria.
COG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OMAiMSTRWEK.
OrthoDBiPOG091H05R1.

Enzyme and pathway databases

BioCyciSAMA326297:GH0T-775-MONOMER.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKATG2_SHEAM
AccessioniPrimary (citable) accession number: A1S3J7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: February 6, 2007
Last modified: September 7, 2016
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.