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A1S2J9

- PUR9_SHEAM

UniProt

A1S2J9 - PUR9_SHEAM

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Protein

Bifunctional purine biosynthesis protein PurH

Gene
purH, Sama_0395
Organism
Shewanella amazonensis (strain ATCC BAA-1098 / SB2B)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transferase

Keywords - Biological processi

Purine biosynthesis

Enzyme and pathway databases

BioCyciSAMA326297:GH0T-424-MONOMER.
UniPathwayiUPA00074; UER00133.
UPA00074; UER00135.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurH
Including the following 2 domains:
Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC:2.1.2.3)
Alternative name(s):
AICAR transformylase
IMP cyclohydrolase (EC:3.5.4.10)
Alternative name(s):
ATIC
IMP synthase
Inosinicase
Gene namesi
Name:purH
Ordered Locus Names:Sama_0395
OrganismiShewanella amazonensis (strain ATCC BAA-1098 / SB2B)
Taxonomic identifieri326297 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
ProteomesiUP000009175: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 529529Bifunctional purine biosynthesis protein PurHUniRule annotationPRO_1000018950Add
BLAST

Proteomic databases

PRIDEiA1S2J9.

Interactioni

Protein-protein interaction databases

STRINGi326297.Sama_0395.

Structurei

3D structure databases

ProteinModelPortaliA1S2J9.

Family & Domainsi

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region By similarity.UniRule annotation

Sequence similaritiesi

Belongs to the PurH family.

Phylogenomic databases

eggNOGiCOG0138.
HOGENOMiHOG000230373.
KOiK00602.
OMAiRAFKTDP.
OrthoDBiEOG6QCDFF.

Family and domain databases

Gene3Di3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPiMF_00139. PurH.
InterProiIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERiPTHR11692. PTHR11692. 1 hit.
PfamiPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR00355. purH. 1 hit.

Sequencei

Sequence statusi: Complete.

A1S2J9-1 [UniParc]FASTAAdd to Basket

« Hide

MNNARPIRRA LLSVSDKTGI LEFAQALHAQ GVELLSTGGT AKLLADNGVP    50
VIEVSDYTGH PEIMDGRVKT LHPKVHGGIL ARRGQDEDVM AANNIGPIDL 100
VAVNLYPFAA TVAKPGCTLE DAIENIDIGG PTMVRAAAKN HKDVVIVVNA 150
KDYDRVLAEM SANGGSTSHA TRFDLAIAAF EHTAAYDGMI ANYFGTMVPA 200
HSSDECHDDS KFPRTFNTQL VKKQDLRYGE NSHQSAAFYV DLNSDEASVA 250
TATQLQGKAL SYNNIADTDA ALECVKEFDA PACVIVKHAN PCGVALGDNL 300
LDAYNRAYKT DPTSAFGGII AFNRELDGET AAAIVERQFV EVIIAPVVSQ 350
AARDVVAKKT NVRLLECGQW TAQTKGLDYK RVNGGLLIQD RDQGMVTEAE 400
LKVVTKRVPT EAELKDLMFC WKVAKFVKSN AIVYAKEGMT IGVGAGQMSR 450
VYSAKIAGIK AADEGLVVEG SVMASDAFFP FRDGIDAAAA AGISCIIQPG 500
GSIRDEEVIA AADEHGMAMV FTNMRHFRH 529
Length:529
Mass (Da):56,677
Last modified:February 6, 2007 - v1
Checksum:iA194486B59037D73
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000507 Genomic DNA. Translation: ABL98605.1.
RefSeqiYP_926275.1. NC_008700.1.

Genome annotation databases

EnsemblBacteriaiABL98605; ABL98605; Sama_0395.
GeneIDi4602650.
KEGGisaz:Sama_0395.
PATRICi23449347. VBISheAma74963_0408.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000507 Genomic DNA. Translation: ABL98605.1 .
RefSeqi YP_926275.1. NC_008700.1.

3D structure databases

ProteinModelPortali A1S2J9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 326297.Sama_0395.

Proteomic databases

PRIDEi A1S2J9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABL98605 ; ABL98605 ; Sama_0395 .
GeneIDi 4602650.
KEGGi saz:Sama_0395.
PATRICi 23449347. VBISheAma74963_0408.

Phylogenomic databases

eggNOGi COG0138.
HOGENOMi HOG000230373.
KOi K00602.
OMAi RAFKTDP.
OrthoDBi EOG6QCDFF.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00133 .
UPA00074 ; UER00135 .
BioCyci SAMA326297:GH0T-424-MONOMER.

Family and domain databases

Gene3Di 3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPi MF_00139. PurH.
InterProi IPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view ]
PANTHERi PTHR11692. PTHR11692. 1 hit.
Pfami PF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view ]
PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view ]
SUPFAMi SSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsi TIGR00355. purH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-1098 / SB2B.

Entry informationi

Entry nameiPUR9_SHEAM
AccessioniPrimary (citable) accession number: A1S2J9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 6, 2007
Last modified: May 14, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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