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A1S2J9

- PUR9_SHEAM

UniProt

A1S2J9 - PUR9_SHEAM

Protein

Bifunctional purine biosynthesis protein PurH

Gene

purH

Organism
Shewanella amazonensis (strain ATCC BAA-1098 / SB2B)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 55 (01 Oct 2014)
      Sequence version 1 (06 Feb 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
    IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
    2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase, Transferase

    Keywords - Biological processi

    Purine biosynthesis

    Enzyme and pathway databases

    BioCyciSAMA326297:GH0T-424-MONOMER.
    UniPathwayiUPA00074; UER00133.
    UPA00074; UER00135.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bifunctional purine biosynthesis protein PurHUniRule annotation
    Including the following 2 domains:
    Phosphoribosylaminoimidazolecarboxamide formyltransferaseUniRule annotation (EC:2.1.2.3UniRule annotation)
    Alternative name(s):
    AICAR transformylaseUniRule annotation
    IMP cyclohydrolaseUniRule annotation (EC:3.5.4.10UniRule annotation)
    Alternative name(s):
    ATICUniRule annotation
    IMP synthaseUniRule annotation
    InosinicaseUniRule annotation
    Gene namesi
    Name:purHUniRule annotation
    Ordered Locus Names:Sama_0395
    OrganismiShewanella amazonensis (strain ATCC BAA-1098 / SB2B)
    Taxonomic identifieri326297 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
    ProteomesiUP000009175: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 529529Bifunctional purine biosynthesis protein PurHPRO_1000018950Add
    BLAST

    Proteomic databases

    PRIDEiA1S2J9.

    Interactioni

    Protein-protein interaction databases

    STRINGi326297.Sama_0395.

    Structurei

    3D structure databases

    ProteinModelPortaliA1S2J9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domaini

    The IMP cyclohydrolase activity resides in the N-terminal region.UniRule annotation

    Sequence similaritiesi

    Belongs to the PurH family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0138.
    HOGENOMiHOG000230373.
    KOiK00602.
    OMAiRAFKTDP.
    OrthoDBiEOG6QCDFF.

    Family and domain databases

    Gene3Di3.40.140.20. 2 hits.
    3.40.50.1380. 1 hit.
    HAMAPiMF_00139. PurH.
    InterProiIPR024051. AICAR_Tfase_dom.
    IPR002695. AICARFT_IMPCHas.
    IPR016193. Cytidine_deaminase-like.
    IPR011607. MGS-like_dom.
    [Graphical view]
    PANTHERiPTHR11692. PTHR11692. 1 hit.
    PfamiPF01808. AICARFT_IMPCHas. 1 hit.
    PF02142. MGS. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
    SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
    SM00851. MGS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52335. SSF52335. 1 hit.
    SSF53927. SSF53927. 1 hit.
    TIGRFAMsiTIGR00355. purH. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A1S2J9-1 [UniParc]FASTAAdd to Basket

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    MNNARPIRRA LLSVSDKTGI LEFAQALHAQ GVELLSTGGT AKLLADNGVP    50
    VIEVSDYTGH PEIMDGRVKT LHPKVHGGIL ARRGQDEDVM AANNIGPIDL 100
    VAVNLYPFAA TVAKPGCTLE DAIENIDIGG PTMVRAAAKN HKDVVIVVNA 150
    KDYDRVLAEM SANGGSTSHA TRFDLAIAAF EHTAAYDGMI ANYFGTMVPA 200
    HSSDECHDDS KFPRTFNTQL VKKQDLRYGE NSHQSAAFYV DLNSDEASVA 250
    TATQLQGKAL SYNNIADTDA ALECVKEFDA PACVIVKHAN PCGVALGDNL 300
    LDAYNRAYKT DPTSAFGGII AFNRELDGET AAAIVERQFV EVIIAPVVSQ 350
    AARDVVAKKT NVRLLECGQW TAQTKGLDYK RVNGGLLIQD RDQGMVTEAE 400
    LKVVTKRVPT EAELKDLMFC WKVAKFVKSN AIVYAKEGMT IGVGAGQMSR 450
    VYSAKIAGIK AADEGLVVEG SVMASDAFFP FRDGIDAAAA AGISCIIQPG 500
    GSIRDEEVIA AADEHGMAMV FTNMRHFRH 529
    Length:529
    Mass (Da):56,677
    Last modified:February 6, 2007 - v1
    Checksum:iA194486B59037D73
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000507 Genomic DNA. Translation: ABL98605.1.
    RefSeqiYP_926275.1. NC_008700.1.

    Genome annotation databases

    EnsemblBacteriaiABL98605; ABL98605; Sama_0395.
    GeneIDi4602650.
    KEGGisaz:Sama_0395.
    PATRICi23449347. VBISheAma74963_0408.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000507 Genomic DNA. Translation: ABL98605.1 .
    RefSeqi YP_926275.1. NC_008700.1.

    3D structure databases

    ProteinModelPortali A1S2J9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 326297.Sama_0395.

    Proteomic databases

    PRIDEi A1S2J9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABL98605 ; ABL98605 ; Sama_0395 .
    GeneIDi 4602650.
    KEGGi saz:Sama_0395.
    PATRICi 23449347. VBISheAma74963_0408.

    Phylogenomic databases

    eggNOGi COG0138.
    HOGENOMi HOG000230373.
    KOi K00602.
    OMAi RAFKTDP.
    OrthoDBi EOG6QCDFF.

    Enzyme and pathway databases

    UniPathwayi UPA00074 ; UER00133 .
    UPA00074 ; UER00135 .
    BioCyci SAMA326297:GH0T-424-MONOMER.

    Family and domain databases

    Gene3Di 3.40.140.20. 2 hits.
    3.40.50.1380. 1 hit.
    HAMAPi MF_00139. PurH.
    InterProi IPR024051. AICAR_Tfase_dom.
    IPR002695. AICARFT_IMPCHas.
    IPR016193. Cytidine_deaminase-like.
    IPR011607. MGS-like_dom.
    [Graphical view ]
    PANTHERi PTHR11692. PTHR11692. 1 hit.
    Pfami PF01808. AICARFT_IMPCHas. 1 hit.
    PF02142. MGS. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
    SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
    SM00851. MGS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52335. SSF52335. 1 hit.
    SSF53927. SSF53927. 1 hit.
    TIGRFAMsi TIGR00355. purH. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-1098 / SB2B.

    Entry informationi

    Entry nameiPUR9_SHEAM
    AccessioniPrimary (citable) accession number: A1S2J9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: February 6, 2007
    Last modified: October 1, 2014
    This is version 55 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzyme, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3