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Protein

Phospho-N-acetylmuramoyl-pentapeptide-transferase

Gene

mraY

Organism
Shewanella amazonensis (strain ATCC BAA-1098 / SB2B)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan.UniRule annotation

Catalytic activityi

UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processCell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
Phospho-N-acetylmuramoyl-pentapeptide-transferaseUniRule annotation (EC:2.7.8.13UniRule annotation)
Alternative name(s):
UDP-MurNAc-pentapeptide phosphotransferaseUniRule annotation
Gene namesi
Name:mraYUniRule annotation
Ordered Locus Names:Sama_0351
OrganismiShewanella amazonensis (strain ATCC BAA-1098 / SB2B)
Taxonomic identifieri326297 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
Proteomesi
  • UP000009175 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei26 – 46HelicalUniRule annotationAdd BLAST21
Transmembranei74 – 94HelicalUniRule annotationAdd BLAST21
Transmembranei97 – 117HelicalUniRule annotationAdd BLAST21
Transmembranei132 – 152HelicalUniRule annotationAdd BLAST21
Transmembranei168 – 188HelicalUniRule annotationAdd BLAST21
Transmembranei199 – 219HelicalUniRule annotationAdd BLAST21
Transmembranei236 – 256HelicalUniRule annotationAdd BLAST21
Transmembranei263 – 283HelicalUniRule annotationAdd BLAST21
Transmembranei288 – 308HelicalUniRule annotationAdd BLAST21
Transmembranei338 – 358HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000030541 – 360Phospho-N-acetylmuramoyl-pentapeptide-transferaseAdd BLAST360

Interactioni

Protein-protein interaction databases

STRINGi326297.Sama_0351.

Structurei

3D structure databases

SMRiA1S2F6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 4 family. MraY subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CPY. Bacteria.
COG0472. LUCA.
HOGENOMiHOG000275122.
KOiK01000.
OMAiLMSPLHH.
OrthoDBiPOG091H00VH.

Family and domain databases

CDDicd06852. GT_MraY. 1 hit.
HAMAPiMF_00038. MraY. 1 hit.
InterProiView protein in InterPro
IPR000715. Glycosyl_transferase_4.
IPR003524. PNAcMuramoyl-5peptid_Trfase.
IPR018480. PNAcMuramoyl-5peptid_Trfase_CS.
PANTHERiPTHR22926. PTHR22926. 1 hit.
PfamiView protein in Pfam
PF00953. Glycos_transf_4. 1 hit.
PF10555. MraY_sig1. 1 hit.
TIGRFAMsiTIGR00445. mraY. 1 hit.
PROSITEiView protein in PROSITE
PS01347. MRAY_1. 1 hit.
PS01348. MRAY_2. 1 hit.

Sequencei

Sequence statusi: Complete.

A1S2F6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLVYLAEYLT QFYTGFNVFS YVTFRAILAL LTALMFSLWW GPKLIERLQV
60 70 80 90 100
LQIGQVVRND GPESHFSKRG TPTMGGLLIL AGIFIGVLLW GDLGSRYVWV
110 120 130 140 150
MLFVLGSFGL IGFIDDYRKV VRKDPKGLIA RWKYIFQSLA ALVVAFYLFY
160 170 180 190 200
STKHPGETQL VVPFFKDILP QLGLMFIVLT YFTIVGASNA VNLTDGLDGL
210 220 230 240 250
AIMPTVMVAA AFALIAYLSG HVQFANYLHI PYLPGSGELV IVCTAIVGAG
260 270 280 290 300
LGFLWFNTYP AQVFMGDVGS LSLGAALGTI AVLVRQEILL VIMGGVFVME
310 320 330 340 350
TLSVILQVGS YKLRGQRIFR MAPIHHHYEL KGWPEPRVIV RFWIISLFLV
360
LLGLATLKLR
Length:360
Mass (Da):40,058
Last modified:February 6, 2007 - v1
Checksum:i7832B133B46D0376
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000507 Genomic DNA. Translation: ABL98562.1.
RefSeqiWP_011758472.1. NC_008700.1.

Genome annotation databases

EnsemblBacteriaiABL98562; ABL98562; Sama_0351.
KEGGisaz:Sama_0351.

Similar proteinsi

Entry informationi

Entry nameiMRAY_SHEAM
AccessioniPrimary (citable) accession number: A1S2F6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 6, 2007
Last modified: June 7, 2017
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families