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Protein

Phosphoenolpyruvate carboxylase

Gene

ppcA

Organism
Thermofilum pendens (strain Hrk 5)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.UniRule annotation

Catalytic activityi

Phosphate + oxaloacetate = H2O + phosphoenolpyruvate + HCO3-.UniRule annotation

Cofactori

Mg2+UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Carbon dioxide fixation

Keywords - Ligandi

Magnesium

Enzyme and pathway databases

BioCyciTPEN368408:GHSG-1320-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxylaseUniRule annotation (EC:4.1.1.31UniRule annotation)
Short name:
PEPCUniRule annotation
Short name:
PEPCaseUniRule annotation
Gene namesi
Name:ppcAUniRule annotation
Ordered Locus Names:Tpen_1265
OrganismiThermofilum pendens (strain Hrk 5)
Taxonomic identifieri368408 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiThermoprotealesThermofilaceaeThermofilum
ProteomesiUP000000641 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 464464Phosphoenolpyruvate carboxylasePRO_0000309617Add
BLAST

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi368408.Tpen_1265.

Structurei

3D structure databases

ProteinModelPortaliA1RZN3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PEPCase type 2 family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1892.
HOGENOMiHOG000009826.
KOiK01595.
OMAiQSAFRYD.

Family and domain databases

Gene3Di3.20.20.60. 1 hit.
HAMAPiMF_01904. PEPcase_type2.
InterProiIPR007566. PEP_COase_arc-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamiPF14010. PEPcase_2. 1 hit.
[Graphical view]
PIRSFiPIRSF006677. UCP006677. 1 hit.
SUPFAMiSSF51621. SSF51621. 1 hit.
TIGRFAMsiTIGR02751. PEPCase_arch. 1 hit.

Sequencei

Sequence statusi: Complete.

A1RZN3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METPRLMCTQ HPDSTVKVPV QEEVEEAVRS FLVYGCDEVM SDYEGKLTPY
60 70 80 90 100
AQPKEIVVKA GELGVPVGEG FYVTVRAPNP RLEDFDRVDL ALEAAVLANY
110 120 130 140 150
YSYKRLGVQA VRWVVLPMTD SAETVRLVQR LLARKTRVLC EEVGQPCEQA
160 170 180 190 200
QLVPLLEDVD SLLRVREILR DLHSALAELG SDPGVLRVFL GKSDSALKAG
210 220 230 240 250
HIASALSLLY ALGESAKAGE ELGLEVKPIL GGGSPPFRGG VNNPRLVGVE
260 270 280 290 300
VQRYRGYSTV TVQSAVRYDA SFSEYQEVRS KLLGGAGGEP GDAGGRVAEL
310 320 330 340 350
ARLAASMYRS LASKYLDFVN EYARSVPTTR DRVSWREYGR ALELEDKLFS
360 370 380 390 400
APRAIVYTAA WYSLGVPPTF LDADFVLEAY RGDFLDEVLG YLPGLEEEWR
410 420 430 440 450
YDAQFYLPRL AGERLGEELV KKVDEALDAM GLRPEPLEPY EKLARTAPAE
460
LRALLLGKVR GFLG
Length:464
Mass (Da):51,243
Last modified:February 6, 2007 - v1
Checksum:i174AF466FC739834
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000505 Genomic DNA. Translation: ABL78663.1.
RefSeqiWP_011752928.1. NC_008698.1.
YP_920666.1. NC_008698.1.

Genome annotation databases

EnsemblBacteriaiABL78663; ABL78663; Tpen_1265.
GeneIDi4600480.
KEGGitpe:Tpen_1265.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000505 Genomic DNA. Translation: ABL78663.1.
RefSeqiWP_011752928.1. NC_008698.1.
YP_920666.1. NC_008698.1.

3D structure databases

ProteinModelPortaliA1RZN3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi368408.Tpen_1265.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABL78663; ABL78663; Tpen_1265.
GeneIDi4600480.
KEGGitpe:Tpen_1265.

Phylogenomic databases

eggNOGiCOG1892.
HOGENOMiHOG000009826.
KOiK01595.
OMAiQSAFRYD.

Enzyme and pathway databases

BioCyciTPEN368408:GHSG-1320-MONOMER.

Family and domain databases

Gene3Di3.20.20.60. 1 hit.
HAMAPiMF_01904. PEPcase_type2.
InterProiIPR007566. PEP_COase_arc-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamiPF14010. PEPcase_2. 1 hit.
[Graphical view]
PIRSFiPIRSF006677. UCP006677. 1 hit.
SUPFAMiSSF51621. SSF51621. 1 hit.
TIGRFAMsiTIGR02751. PEPCase_arch. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Hrk 5.

Entry informationi

Entry nameiCAPPA_THEPD
AccessioniPrimary (citable) accession number: A1RZN3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: February 6, 2007
Last modified: July 22, 2015
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.