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A1RZC9 (A1RZC9_THEPD) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 37. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Dihydroorotate dehydrogenase HAMAP MF_00224
Short name=DHOD HAMAP MF_00224
Short name=DHODase HAMAP MF_00224
Short name=DHOdehase HAMAP MF_00224
EC=1.3.-.- HAMAP MF_00224
Gene names
Name:pyrD HAMAP MF_00224
Ordered Locus Names:Tpen_1161
OrganismThermofilum pendens (strain Hrk 5)
Taxonomic identifier368408 [NCBI]
Taxonomic lineageArchaea › Crenarchaeota › Thermoprotei › Thermoproteales › Thermofilaceae › Thermofilum

Protein attributes

Sequence length299 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the conversion of dihydroorotate to orotate By similarity. HAMAP MF_00224

Catalytic activity

(S)-dihydroorotate + acceptor = orotate + reduced acceptor. HAMAP MF_00224

Cofactor

Binds 1 FMN per subunit By similarity. HAMAP MF_00224

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway. HAMAP MF_00224

Subcellular location

Cytoplasm By similarity HAMAP MF_00224.

Sequence similarities

Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily. HAMAP MF_00224

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site1271Nucleophile By similarity PIRSR PIRSR000164-1

Sequences

Sequence LengthMass (Da)Tools
A1RZC9 [UniParc].

Last modified February 6, 2007. Version 1.
Checksum: BD6B79E3312713F3

FASTA29931,165
        10         20         30         40         50         60 
MVELSVEVAG LRLRNPVVVA SGVLGVSVGL MKRAEDAGAG AVTSKTVTLN PREGYPNPVV 

        70         80         90        100        110        120 
YELDYGLVNS MGLPNPGAEE MGRILREARR VLGIPVIASI GASTPDEALR IAEALEGFDA 

       130        140        150        160        170        180 
LELNASCPHV KGLGADLMSD PDAVYGIVSA LKSSGYRVFL KLSPHGDYLA VARKAYSAGV 

       190        200        210        220        230        240 
DGFTAINTAK AMVIDVYARK PVLGGVVGGL SGRAIHPIAV RVVYELHREF PEVPVIGTGG 

       250        260        270        280        290 
VEGWVEAVEL ILAGASAVGV GTALKRGFEV IGEILGGIER YLRDEGFPSV ESIVGLAHK

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References

[1]"Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction."
Anderson I., Rodriguez J., Susanti D., Porat I., Reich C., Ulrich L.E., Elkins J.G., Mavromatis K., Lykidis A., Kim E., Thompson L.S., Nolan M., Land M., Copeland A., Lapidus A., Lucas S., Detter C., Zhulin I.B. expand/collapse author list , Olsen G.J., Whitman W., Mukhopadhyay B., Bristow J., Kyrpides N.
J. Bacteriol. 190:2957-2965(2008) [PubMed: 18263724] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Hrk 5.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000505 Genomic DNA. Translation: ABL78559.1.
RefSeqYP_920562.1. NC_008698.1.

3D structure databases

ProteinModelPortalA1RZC9.
ModBaseSearch...

Protein-protein interaction databases

STRINGA1RZC9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4602163.
GenomeReviewsGene locus Tpen_1161 in contig CP000505_GR.
KEGGtpe:Tpen_1161.

Phylogenomic databases

eggNOGarNOG04551.
HOGENOMHBG472415.
OMAVALRMVW.
PhylomeDBA1RZC9.

Enzyme and pathway databases

BioCycTPEN368408:TPEN_1161-MONOMER.

Family and domain databases

HAMAPMF_00224. DHO_dh_type1.
[Tree]
InterProIPR013785. Aldolase_TIM.
IPR005720. Dihydroorotate_DH.
IPR024920. Dihydroorotate_DH_1.
IPR012135. Dihydroorotate_DH_1_2.
IPR001295. Dihydroorotate_DH_CS.
[Graphical view]
Gene3DG3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KOK00226.
PfamPF01180. DHO_dh. 1 hit.
[Graphical view]
PIRSFPIRSF000164. DHO_oxidase. 1 hit.
TIGRFAMsTIGR01037. PyrD_sub1_fam. 1 hit.
PROSITEPS00911. DHODEHASE_1. 1 hit.
PS00912. DHODEHASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA1RZC9_THEPD
AccessionPrimary (citable) accession number: A1RZC9
Entry history
Integrated into UniProtKB/TrEMBL: February 6, 2007
Last sequence update: February 6, 2007
Last modified: January 25, 2012
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info