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A1RYP8 (A1RYP8_THEPD) Unreviewed, UniProtKB/TrEMBL

Last modified November 16, 2011. Version 32. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesSubmitted name:
Hydroxymethylglutaryl-CoA reductase, degradative EMBL ABL78328.1
EC=1.1.1.88 EMBL ABL78328.1
Gene names
Ordered Locus Names:Tpen_0927
OrganismThermofilum pendens (strain Hrk 5)
Taxonomic identifier368408 [NCBI]
Taxonomic lineageArchaea › Crenarchaeota › Thermoprotei › Thermoproteales › Thermofilaceae › Thermofilum

Protein attributes

Sequence length428 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Sequence similarities

Belongs to the HMG-CoA reductase family. RuleBase RU004268

Sequences

Sequence LengthMass (Da)Tools
A1RYP8 [UniParc].

Last modified February 6, 2007. Version 1.
Checksum: 235641F8A91723FB

FASTA42846,395
        10         20         30         40         50         60 
MSSEQRTSRI PEFYKKPIEE RLKIVAEFAG LTEEEVALLK NFGNLDRKIA DSMIENVIGA 

        70         80         90        100        110        120 
MSYPFAVAVN FLINGKDYIV PMVIEEASVV AAASNAARVM RRDGGIKSVA TQPIMIGQIQ 

       130        140        150        160        170        180 
VLGVKDPWYK RMVLLEHKEE ILQKANEVDP VLVKFGGGAR DLEARVVESP RGPMLIVHLL 

       190        200        210        220        230        240 
VDVRDAMGAN AVNTMAEKVA PMIERLTGGR VLLRIISNLA DRRLVRSWVK VYKEDIGGEE 

       250        260        270        280        290        300 
VVDAIVDAWA FAAADPYRAA THNKGIMNGV IAVALATAQD HRAIEAGAHA YAARTGRYMP 

       310        320        330        340        350        360 
LSTWEKDQDG NLVGTLEMPM AVGTIGGATK VHPVAKIALK ILGVKTATEL AEVMGAVGLA 

       370        380        390        400        410        420 
QNFAALRALA TEGIQKGHMR LHARNLAIMA GATGDLIDRV VEIMVSEGKI NFAYAQELVN 


KLSKEGRA

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References

[1]"Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction."
Anderson I., Rodriguez J., Susanti D., Porat I., Reich C., Ulrich L.E., Elkins J.G., Mavromatis K., Lykidis A., Kim E., Thompson L.S., Nolan M., Land M., Copeland A., Lapidus A., Lucas S., Detter C., Zhulin I.B. expand/collapse author list , Olsen G.J., Whitman W., Mukhopadhyay B., Bristow J., Kyrpides N.
J. Bacteriol. 190:2957-2965(2008) [PubMed: 18263724] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Hrk 5.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000505 Genomic DNA. Translation: ABL78328.1.
RefSeqYP_920331.1. NC_008698.1.

3D structure databases

ProteinModelPortalA1RYP8.
SMRA1RYP8. Positions 7-425.
ModBaseSearch...

Protein-protein interaction databases

STRINGA1RYP8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4600750.
GenomeReviewsGene locus Tpen_0927 in contig CP000505_GR.
KEGGtpe:Tpen_0927.

Phylogenomic databases

eggNOGarNOG04678.
HOGENOMHBG477902.
OMANNKGIMN.
ProtClustDBCLSK731318.

Enzyme and pathway databases

BioCycTPEN368408:TPEN_0927-MONOMER.

Family and domain databases

InterProIPR002202. HMG_CoA_Rdtase.
IPR004553. HMG_CoA_Rdtase_bac-typ.
IPR023074. HMG_CoA_Rdtase_cat.
IPR023076. HMG_CoA_Rdtase_CS.
IPR009023. HMG_CoA_Rdtase_NAD(P)-bd.
IPR009029. HMG_CoA_Rdtase_sub-bd.
[Graphical view]
Gene3DG3DSA:3.30.70.420. G3DSA:3.30.70.420. 1 hit.
G3DSA:3.90.770.10. HMG-CoA_red. 2 hits.
KOK00054.
PANTHERPTHR10572. HMG-CoA_red. 1 hit.
PfamPF00368. HMG-CoA_red. 1 hit.
[Graphical view]
PRINTSPR00071. HMGCOARDTASE.
SUPFAMSSF55035. HMG_CoA_NAD_bind. 1 hit.
SSF56542. HMG_CoA_sub_bind. 1 hit.
TIGRFAMsTIGR00532. HMG_CoA_R_NAD. 1 hit.
PROSITEPS00066. HMG_COA_REDUCTASE_1. 1 hit.
PS00318. HMG_COA_REDUCTASE_2. 1 hit.
PS01192. HMG_COA_REDUCTASE_3. 1 hit.
PS50065. HMG_COA_REDUCTASE_4. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA1RYP8_THEPD
AccessionPrimary (citable) accession number: A1RYP8
Entry history
Integrated into UniProtKB/TrEMBL: February 6, 2007
Last sequence update: February 6, 2007
Last modified: November 16, 2011
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info