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A1RYD7

- SYE_THEPD

UniProt

A1RYD7 - SYE_THEPD

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Protein

Glutamate--tRNA ligase

Gene
gltX, Tpen_0816
Organism
Thermofilum pendens (strain Hrk 5)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) By similarity.UniRule annotation

Catalytic activityi

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. glutamate-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. glutamyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciTPEN368408:GHSG-866-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate--tRNA ligase (EC:6.1.1.17)
Alternative name(s):
Glutamyl-tRNA synthetase
Short name:
GluRS
Gene namesi
Name:gltX
Ordered Locus Names:Tpen_0816
OrganismiThermofilum pendens (strain Hrk 5)
Taxonomic identifieri368408 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiThermoprotealesThermofilaceaeThermofilum
ProteomesiUP000000641: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 569569Glutamate--tRNA ligaseUniRule annotationPRO_1000001982Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi368408.Tpen_0816.

Structurei

3D structure databases

ProteinModelPortaliA1RYD7.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi108 – 11811"HIGH" regionUniRule annotationAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0008.
HOGENOMiHOG000073585.
KOiK01885.
OMAiAFRIIDT.

Family and domain databases

Gene3Di1.10.1160.10. 1 hit.
3.40.50.620. 2 hits.
HAMAPiMF_00022_A. Glu_tRNA_synth_A.
InterProiIPR004526. Glu-tRNA-synth_arc/euk.
IPR000924. Glu/Gln-tRNA-synth.
IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
IPR020059. Glu/Gln-tRNA-synth_Ib_codon-bd.
IPR022888. Glu_tRNA_synth_arc.
IPR011035. Ribosomal_L25/Gln-tRNA_synth.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERiPTHR10119. PTHR10119. 1 hit.
PfamiPF00749. tRNA-synt_1c. 1 hit.
PF03950. tRNA-synt_1c_C. 1 hit.
[Graphical view]
PRINTSiPR00987. TRNASYNTHGLU.
SUPFAMiSSF50715. SSF50715. 1 hit.
TIGRFAMsiTIGR00463. gltX_arch. 1 hit.

Sequencei

Sequence statusi: Complete.

A1RYD7-1 [UniParc]FASTAAdd to Basket

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MEVDIRRVAL KHALANAVKF GGKARVDSVV SKVFAEVPEA RKAAKEVVEL    50
VKEVVEEVNS MSPESQASLL SELWPEALSG ERKVEVKRLP PLPGAEEVGG 100
KVVTRFAPNP DFVLHLGSAR PAILNYYYAK KMYNGKFILR FEDTDPRTKR 150
PMPEAYDLIR EDLRWLGTPW DEEYIQSQRM EVYYEVAEAL IKSGNAYVCT 200
HSQDEIKAFR DAGKPDPCSF LPPEEHMERW EKMLSGEYPE GAAVLRIKTD 250
PAHPNPSVRD WIAFRVLDTE KTPHPLTGDK YRVWPTYNFA CAVDDHMLGV 300
THVLRGEEHA VNTLKQEYVY RHMGWKPPVS IHFGRMNLEG MVLSKSVIRR 350
GIEKGLFSSI DDIRLGTLRA LRRRGILPEA IWDLVLEVGI KPSTARVSVD 400
KLHAFNRKYL EPRANRYMFV PEPAKVASIE GLEAPITAEV IVHPSFPERG 450
RRRITFSKPE VYLPSDVASS MVRLMGLGNF EVVDGGSKLR YLNNDVSFAK 500
KHELPIVQWA PVESSVRGRV LKAAGTKIEE ISGYGEPSLA ELPPGEQVQF 550
VRLGFVRVEG PETYIFTHD 569
Length:569
Mass (Da):64,322
Last modified:February 6, 2007 - v1
Checksum:iBCA13B7C3A20DCB9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000505 Genomic DNA. Translation: ABL78217.1.
RefSeqiWP_011752482.1. NC_008698.1.
YP_920220.1. NC_008698.1.

Genome annotation databases

EnsemblBacteriaiABL78217; ABL78217; Tpen_0816.
GeneIDi4601986.
KEGGitpe:Tpen_0816.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000505 Genomic DNA. Translation: ABL78217.1 .
RefSeqi WP_011752482.1. NC_008698.1.
YP_920220.1. NC_008698.1.

3D structure databases

ProteinModelPortali A1RYD7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 368408.Tpen_0816.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABL78217 ; ABL78217 ; Tpen_0816 .
GeneIDi 4601986.
KEGGi tpe:Tpen_0816.

Phylogenomic databases

eggNOGi COG0008.
HOGENOMi HOG000073585.
KOi K01885.
OMAi AFRIIDT.

Enzyme and pathway databases

BioCyci TPEN368408:GHSG-866-MONOMER.

Family and domain databases

Gene3Di 1.10.1160.10. 1 hit.
3.40.50.620. 2 hits.
HAMAPi MF_00022_A. Glu_tRNA_synth_A.
InterProi IPR004526. Glu-tRNA-synth_arc/euk.
IPR000924. Glu/Gln-tRNA-synth.
IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
IPR020059. Glu/Gln-tRNA-synth_Ib_codon-bd.
IPR022888. Glu_tRNA_synth_arc.
IPR011035. Ribosomal_L25/Gln-tRNA_synth.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
PANTHERi PTHR10119. PTHR10119. 1 hit.
Pfami PF00749. tRNA-synt_1c. 1 hit.
PF03950. tRNA-synt_1c_C. 1 hit.
[Graphical view ]
PRINTSi PR00987. TRNASYNTHGLU.
SUPFAMi SSF50715. SSF50715. 1 hit.
TIGRFAMsi TIGR00463. gltX_arch. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Hrk 5.

Entry informationi

Entry nameiSYE_THEPD
AccessioniPrimary (citable) accession number: A1RYD7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 6, 2007
Last modified: September 3, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi