A1RY85 (A1RY85_THEPD) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Deoxyribose-phosphate aldolase HAMAP MF_00114
Short name=DERA HAMAP MF_00114
EC=4.1.2.4 HAMAP MF_00114

Alternative name(s):
2-deoxy-D-ribose 5-phosphate aldolase HAMAP MF_00114
Phosphodeoxyriboaldolase HAMAP MF_00114

Gene names

Name:	deoC HAMAP MF_00114
Ordered Locus Names:	Tpen_0763

Organism

Thermofilum pendens (strain Hrk 5)

Taxonomic identifier

368408 [NCBI]

Taxonomic lineage

Archaea › Crenarchaeota › Thermoprotei › Thermoproteales › Thermofilaceae › Thermofilum

Protein attributes

Sequence length	242 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate By similarity. HAMAP MF_00114
Catalytic activity	2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde. HAMAP MF_00114
Pathway	Carbohydrate degradation; 2-deoxy-D-ribose 1-phosphate degradation; D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate: step 2/2. HAMAP MF_00114
Subcellular location	Cytoplasm By similarity HAMAP MF_00114.
Sequence similarities	Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily. HAMAP MF_00114

Ontologies

Keywords
Cellular component	Cytoplasm HAMAP MF_00114
Ligand	Schiff base HAMAP MF_00114
Molecular function	Lyase HAMAP MF_00114 EMBL ABL78165.1
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	carbohydrate catabolic process Inferred from electronic annotation. Source: HAMAP deoxyribonucleotide catabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	deoxyribose-phosphate aldolase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	170	1	Schiff-base intermediate with acetaldehyde By similarity HAMAP MF_00114
	Active site	200	1	By similarity HAMAP MF_00114

Sequences

	Sequence		Length	Mass (Da)
	A1RY85 [UniParc]. Last modified February 6, 2007. Version 1. Checksum: 41C5FECC953EF040	FASTA	242	26,363
	10 20 30 40 50 60 MYYKNVIARP FPDPESLVEE VSRIIDHTNL RPEASEKELE KTCREAVDYG FYACCVPGFF 70 80 90 100 110 120 VEKAVKIVDG AAKVVTVAGF PHGNSPRAVK VAEVKAAFEK GADEVDVVVN ISLVKSGLLE 130 140 150 160 170 180 EAVSEVQEIL DVANESGGVL KVILETGYLT AEEVYRLGRE LARIGVHFLK TSTGFGPRGA 190 200 210 220 230 240 TPEDILVMRR AVEGTRTKLK AAGGIRTGLQ ALFFYLLGVE RIGTSSSLQI VNDLRALKEL LH

References

[1]

"Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction." Anderson I., Rodriguez J., Susanti D., Porat I., Reich C., Ulrich L.E., Elkins J.G., Mavromatis K., Lykidis A., Kim E., Thompson L.S., Nolan M., Land M., Copeland A., Lapidus A., Lucas S., Detter C., Zhulin I.B. , Olsen G.J., Whitman W., Mukhopadhyay B., Bristow J., Kyrpides N. J. Bacteriol. 190:2957-2965(2008) [PubMed: 18263724] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Hrk 5.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000505 Genomic DNA. Translation: ABL78165.1.
RefSeq	YP_920168.1. NC_008698.1.
3D structure databases
ProteinModelPortal	A1RY85.
ModBase	Search...
Protein-protein interaction databases
STRING	A1RY85.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4601084.
GenomeReviews	Gene locus Tpen_0763 in contig CP000505_GR.
KEGG	tpe:Tpen_0763.
Phylogenomic databases
eggNOG	arNOG10952.
HOGENOM	HBG636421.
OMA	IDHTNLK.
PhylomeDB	A1RY85.
Enzyme and pathway databases
BioCyc	TPEN368408:TPEN_0763-MONOMER.
Family and domain databases
HAMAP	MF_00114. DeoC_type1. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR011343. DeoC. IPR002915. DeoC/AroFGH_arch. IPR022979. Deoxyribose_phosphate_aldo_1. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K01619.
PANTHER	PTHR10889. DeoC. 1 hit.
Pfam	PF01791. DeoC. 1 hit. [Graphical view]
PIRSF	PIRSF001357. DeoC. 1 hit.
TIGRFAMs	TIGR00126. DeoC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

A1RY85_THEPD

Accession

Primary (citable) accession number: A1RY85

Entry history

Integrated into UniProtKB/TrEMBL:	February 6, 2007
Last sequence update:	February 6, 2007
Last modified:	November 16, 2011
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)