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Protein

DNA ligase 2

Gene

lig2

Organism
Thermofilum pendens (strain DSM 2475 / Hrk 5)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n)-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) + AMP + diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei263ATPUniRule annotation1
Active sitei265N6-AMP-lysine intermediateUniRule annotation1
Binding sitei270ATPUniRule annotation1
Binding sitei285ATPUniRule annotation1
Binding sitei314ATPUniRule annotation1
Binding sitei354ATPUniRule annotation1
Binding sitei432ATPUniRule annotation1
Binding sitei438ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processCell cycle, Cell division, DNA damage, DNA recombination, DNA repair, DNA replication
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligase 2UniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP] 2UniRule annotation
Gene namesi
Name:lig2UniRule annotation
Ordered Locus Names:Tpen_0750
OrganismiThermofilum pendens (strain DSM 2475 / Hrk 5)
Taxonomic identifieri368408 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiThermoprotealesThermofilaceaeThermofilum
Proteomesi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003652661 – 601DNA ligase 2Add BLAST601

Interactioni

Protein-protein interaction databases

STRINGi368408.Tpen_0750

Structurei

3D structure databases

ProteinModelPortaliA1RY72
SMRiA1RY72
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01347 Archaea
COG1793 LUCA
HOGENOMiHOG000036008
KOiK10747
OMAiWIKYKRD
OrthoDBiPOG093Z03L0

Family and domain databases

Gene3Di1.10.3260.10, 1 hit
HAMAPiMF_00407 DNA_ligase, 1 hit
InterProiView protein in InterPro
IPR022865 DNA_ligae_ATP-dep_bac/arc
IPR000977 DNA_ligase_ATP-dep
IPR012309 DNA_ligase_ATP-dep_C
IPR012310 DNA_ligase_ATP-dep_cent
IPR016059 DNA_ligase_ATP-dep_CS
IPR012308 DNA_ligase_ATP-dep_N
IPR036599 DNA_ligase_N_sf
IPR012340 NA-bd_OB-fold
PfamiView protein in Pfam
PF04679 DNA_ligase_A_C, 1 hit
PF01068 DNA_ligase_A_M, 1 hit
PF04675 DNA_ligase_A_N, 1 hit
SUPFAMiSSF117018 SSF117018, 1 hit
SSF50249 SSF50249, 1 hit
TIGRFAMsiTIGR00574 dnl1, 1 hit
PROSITEiView protein in PROSITE
PS00697 DNA_LIGASE_A1, 1 hit
PS50160 DNA_LIGASE_A3, 1 hit

Sequencei

Sequence statusi: Complete.

A1RY72-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGAAGDLPYS VLADFYERIE STSSRLAMTD YLVALFKKTP PEVIDKVVYL
60 70 80 90 100
TQGQLRPDYE GVELGVAEKL ALRALAKASG RHLKDVEDLY KKTGDIGAVA
110 120 130 140 150
EKLLTAPGGG LLEFFGTPVQ KKELTVSQVY SALMKIAQAS GEGAQETKVN
160 170 180 190 200
TLVALLQDAK PKEARYILRT VLGRLRLGIA DMTILDALAA AFAGSKAARD
210 220 230 240 250
VIERAYTKHP DLGYIAKLLA TKGLDAVASL KIEVGIPVLP MLAERLSDPA
260 270 280 290 300
EILEKLGGKC LAEYKYDGER VQAHKSGDKV LLFSRRLENI THHYPDVVEY
310 320 330 340 350
VKRLKVREAI VEGEIVAYNP DTGEMLPFQE LMHRRRKYDV EKAMKEYPVR
360 370 380 390 400
VYLFDVIYMD GEELIEKPLD QRRLILEKIV PEGDEDILLS TAKVVGDAKD
410 420 430 440 450
LLHFFEQAIS EGCEGVMCKS IGPGSIYQMG ARGWLWIKFK RDYRMEMTDT
460 470 480 490 500
VDLVVVGGFH GRGKRAGTYG ALLMAAYDPE TDTFKTVCKV GTGFTDEDLA
510 520 530 540 550
KLPELLDPYK IPHRHPRVFS KIEADVWFVP AVVLEIIGAE ITLSPLHTCA
560 570 580 590 600
LNKLEEGAGL AIRFPRFTGR YRFDKKPEQA TTESELIEMY KSQKKTALQQ

S
Length:601
Mass (Da):66,943
Last modified:February 6, 2007 - v1
Checksum:i8AA565878E7AF78B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000505 Genomic DNA Translation: ABL78152.1
RefSeqiWP_011752417.1, NC_008698.1

Genome annotation databases

EnsemblBacteriaiABL78152; ABL78152; Tpen_0750
GeneIDi4600401
KEGGitpe:Tpen_0750

Entry informationi

Entry nameiDNLI2_THEPD
AccessioniPrimary (citable) accession number: A1RY72
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: February 6, 2007
Last modified: March 28, 2018
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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