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A1RY72

- DNLI2_THEPD

UniProt

A1RY72 - DNLI2_THEPD

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Protein
DNA ligase 2
Gene
lig2, Tpen_0750
Organism
Thermofilum pendens (strain Hrk 5)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair By similarity.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

Cofactori

Divalent metal cations By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei263 – 2631ATP By similarity
Active sitei265 – 2651N6-AMP-lysine intermediate By similarity
Binding sitei270 – 2701ATP By similarity
Binding sitei285 – 2851ATP By similarity
Binding sitei314 – 3141ATP By similarity
Binding sitei354 – 3541ATP By similarity
Binding sitei432 – 4321ATP By similarity
Binding sitei438 – 4381ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
  4. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. DNA ligation involved in DNA repair Source: InterPro
  2. DNA recombination Source: UniProtKB-HAMAP
  3. DNA replication Source: UniProtKB-HAMAP
  4. cell cycle Source: UniProtKB-KW
  5. cell division Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Cell cycle, Cell division, DNA damage, DNA recombination, DNA repair, DNA replication

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciTPEN368408:GHSG-797-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligase 2 (EC:6.5.1.1)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP] 2
Gene namesi
Name:lig2
Ordered Locus Names:Tpen_0750
OrganismiThermofilum pendens (strain Hrk 5)
Taxonomic identifieri368408 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiThermoprotealesThermofilaceaeThermofilum
ProteomesiUP000000641: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 601601DNA ligase 2UniRule annotation
PRO_0000365266Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi368408.Tpen_0750.

Structurei

3D structure databases

ProteinModelPortaliA1RY72.
SMRiA1RY72. Positions 7-595.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1793.
HOGENOMiHOG000036008.
KOiK10747.
OMAiCTDIGEL.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPiMF_00407. DNA_ligase.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1RY72-1 [UniParc]FASTAAdd to Basket

« Hide

MGAAGDLPYS VLADFYERIE STSSRLAMTD YLVALFKKTP PEVIDKVVYL    50
TQGQLRPDYE GVELGVAEKL ALRALAKASG RHLKDVEDLY KKTGDIGAVA 100
EKLLTAPGGG LLEFFGTPVQ KKELTVSQVY SALMKIAQAS GEGAQETKVN 150
TLVALLQDAK PKEARYILRT VLGRLRLGIA DMTILDALAA AFAGSKAARD 200
VIERAYTKHP DLGYIAKLLA TKGLDAVASL KIEVGIPVLP MLAERLSDPA 250
EILEKLGGKC LAEYKYDGER VQAHKSGDKV LLFSRRLENI THHYPDVVEY 300
VKRLKVREAI VEGEIVAYNP DTGEMLPFQE LMHRRRKYDV EKAMKEYPVR 350
VYLFDVIYMD GEELIEKPLD QRRLILEKIV PEGDEDILLS TAKVVGDAKD 400
LLHFFEQAIS EGCEGVMCKS IGPGSIYQMG ARGWLWIKFK RDYRMEMTDT 450
VDLVVVGGFH GRGKRAGTYG ALLMAAYDPE TDTFKTVCKV GTGFTDEDLA 500
KLPELLDPYK IPHRHPRVFS KIEADVWFVP AVVLEIIGAE ITLSPLHTCA 550
LNKLEEGAGL AIRFPRFTGR YRFDKKPEQA TTESELIEMY KSQKKTALQQ 600
S 601
Length:601
Mass (Da):66,943
Last modified:February 6, 2007 - v1
Checksum:i8AA565878E7AF78B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000505 Genomic DNA. Translation: ABL78152.1.
RefSeqiWP_011752417.1. NC_008698.1.
YP_920155.1. NC_008698.1.

Genome annotation databases

EnsemblBacteriaiABL78152; ABL78152; Tpen_0750.
GeneIDi4600401.
KEGGitpe:Tpen_0750.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000505 Genomic DNA. Translation: ABL78152.1 .
RefSeqi WP_011752417.1. NC_008698.1.
YP_920155.1. NC_008698.1.

3D structure databases

ProteinModelPortali A1RY72.
SMRi A1RY72. Positions 7-595.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 368408.Tpen_0750.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABL78152 ; ABL78152 ; Tpen_0750 .
GeneIDi 4600401.
KEGGi tpe:Tpen_0750.

Phylogenomic databases

eggNOGi COG1793.
HOGENOMi HOG000036008.
KOi K10747.
OMAi CTDIGEL.

Enzyme and pathway databases

BioCyci TPEN368408:GHSG-797-MONOMER.

Family and domain databases

Gene3Di 1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPi MF_00407. DNA_ligase.
InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view ]
Pfami PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view ]
SUPFAMi SSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00574. dnl1. 1 hit.
PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Hrk 5.

Entry informationi

Entry nameiDNLI2_THEPD
AccessioniPrimary (citable) accession number: A1RY72
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: February 6, 2007
Last modified: September 3, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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