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A1RY72

- DNLI2_THEPD

UniProt

A1RY72 - DNLI2_THEPD

Protein

DNA ligase 2

Gene

lig2

Organism
Thermofilum pendens (strain Hrk 5)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 60 (01 Oct 2014)
      Sequence version 1 (06 Feb 2007)
      Previous versions | rss
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    Functioni

    DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

    Catalytic activityi

    ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

    Cofactori

    Divalent metal cations.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei263 – 2631ATPUniRule annotation
    Active sitei265 – 2651N6-AMP-lysine intermediateUniRule annotation
    Binding sitei270 – 2701ATPUniRule annotation
    Binding sitei285 – 2851ATPUniRule annotation
    Binding sitei314 – 3141ATPUniRule annotation
    Binding sitei354 – 3541ATPUniRule annotation
    Binding sitei432 – 4321ATPUniRule annotation
    Binding sitei438 – 4381ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. DNA binding Source: InterPro
    3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
    4. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW
    3. DNA ligation involved in DNA repair Source: InterPro
    4. DNA recombination Source: UniProtKB-HAMAP
    5. DNA replication Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Cell cycle, Cell division, DNA damage, DNA recombination, DNA repair, DNA replication

    Keywords - Ligandi

    ATP-binding, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciTPEN368408:GHSG-797-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA ligase 2UniRule annotation (EC:6.5.1.1UniRule annotation)
    Alternative name(s):
    Polydeoxyribonucleotide synthase [ATP] 2UniRule annotation
    Gene namesi
    Name:lig2UniRule annotation
    Ordered Locus Names:Tpen_0750
    OrganismiThermofilum pendens (strain Hrk 5)
    Taxonomic identifieri368408 [NCBI]
    Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiThermoprotealesThermofilaceaeThermofilum
    ProteomesiUP000000641: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 601601DNA ligase 2PRO_0000365266Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi368408.Tpen_0750.

    Structurei

    3D structure databases

    ProteinModelPortaliA1RY72.
    SMRiA1RY72. Positions 7-595.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ATP-dependent DNA ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1793.
    HOGENOMiHOG000036008.
    KOiK10747.
    OMAiCTDIGEL.

    Family and domain databases

    Gene3Di1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    HAMAPiMF_00407. DNA_ligase.
    InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view]
    PfamiPF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsiTIGR00574. dnl1. 1 hit.
    PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A1RY72-1 [UniParc]FASTAAdd to Basket

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    MGAAGDLPYS VLADFYERIE STSSRLAMTD YLVALFKKTP PEVIDKVVYL    50
    TQGQLRPDYE GVELGVAEKL ALRALAKASG RHLKDVEDLY KKTGDIGAVA 100
    EKLLTAPGGG LLEFFGTPVQ KKELTVSQVY SALMKIAQAS GEGAQETKVN 150
    TLVALLQDAK PKEARYILRT VLGRLRLGIA DMTILDALAA AFAGSKAARD 200
    VIERAYTKHP DLGYIAKLLA TKGLDAVASL KIEVGIPVLP MLAERLSDPA 250
    EILEKLGGKC LAEYKYDGER VQAHKSGDKV LLFSRRLENI THHYPDVVEY 300
    VKRLKVREAI VEGEIVAYNP DTGEMLPFQE LMHRRRKYDV EKAMKEYPVR 350
    VYLFDVIYMD GEELIEKPLD QRRLILEKIV PEGDEDILLS TAKVVGDAKD 400
    LLHFFEQAIS EGCEGVMCKS IGPGSIYQMG ARGWLWIKFK RDYRMEMTDT 450
    VDLVVVGGFH GRGKRAGTYG ALLMAAYDPE TDTFKTVCKV GTGFTDEDLA 500
    KLPELLDPYK IPHRHPRVFS KIEADVWFVP AVVLEIIGAE ITLSPLHTCA 550
    LNKLEEGAGL AIRFPRFTGR YRFDKKPEQA TTESELIEMY KSQKKTALQQ 600
    S 601
    Length:601
    Mass (Da):66,943
    Last modified:February 6, 2007 - v1
    Checksum:i8AA565878E7AF78B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000505 Genomic DNA. Translation: ABL78152.1.
    RefSeqiWP_011752417.1. NC_008698.1.
    YP_920155.1. NC_008698.1.

    Genome annotation databases

    EnsemblBacteriaiABL78152; ABL78152; Tpen_0750.
    GeneIDi4600401.
    KEGGitpe:Tpen_0750.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000505 Genomic DNA. Translation: ABL78152.1 .
    RefSeqi WP_011752417.1. NC_008698.1.
    YP_920155.1. NC_008698.1.

    3D structure databases

    ProteinModelPortali A1RY72.
    SMRi A1RY72. Positions 7-595.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 368408.Tpen_0750.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABL78152 ; ABL78152 ; Tpen_0750 .
    GeneIDi 4600401.
    KEGGi tpe:Tpen_0750.

    Phylogenomic databases

    eggNOGi COG1793.
    HOGENOMi HOG000036008.
    KOi K10747.
    OMAi CTDIGEL.

    Enzyme and pathway databases

    BioCyci TPEN368408:GHSG-797-MONOMER.

    Family and domain databases

    Gene3Di 1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    HAMAPi MF_00407. DNA_ligase.
    InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view ]
    Pfami PF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsi TIGR00574. dnl1. 1 hit.
    PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Hrk 5.

    Entry informationi

    Entry nameiDNLI2_THEPD
    AccessioniPrimary (citable) accession number: A1RY72
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 3, 2009
    Last sequence update: February 6, 2007
    Last modified: October 1, 2014
    This is version 60 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3