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A1RY72 (DNLI2_THEPD) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
DNA ligase 2

EC=6.5.1.1
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP] 2
Gene names
Name:lig2
Ordered Locus Names:Tpen_0750
OrganismThermofilum pendens (strain Hrk 5) [Reference proteome] [HAMAP]
Taxonomic identifier368408 [NCBI]
Taxonomic lineageArchaeaCrenarchaeotaThermoproteiThermoprotealesThermofilaceaeThermofilum

Protein attributes

Sequence length601 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair By similarity. HAMAP-Rule MF_00407

Catalytic activity

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m). HAMAP-Rule MF_00407

Cofactor

Divalent metal cations By similarity. HAMAP-Rule MF_00407

Sequence similarities

Belongs to the ATP-dependent DNA ligase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 601601DNA ligase 2 HAMAP-Rule MF_00407
PRO_0000365266

Sites

Active site2651N6-AMP-lysine intermediate By similarity
Binding site2631ATP By similarity
Binding site2701ATP By similarity
Binding site2851ATP By similarity
Binding site3141ATP By similarity
Binding site3541ATP By similarity
Binding site4321ATP By similarity
Binding site4381ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
A1RY72 [UniParc].

Last modified February 6, 2007. Version 1.
Checksum: 8AA565878E7AF78B

FASTA60166,943
        10         20         30         40         50         60 
MGAAGDLPYS VLADFYERIE STSSRLAMTD YLVALFKKTP PEVIDKVVYL TQGQLRPDYE 

        70         80         90        100        110        120 
GVELGVAEKL ALRALAKASG RHLKDVEDLY KKTGDIGAVA EKLLTAPGGG LLEFFGTPVQ 

       130        140        150        160        170        180 
KKELTVSQVY SALMKIAQAS GEGAQETKVN TLVALLQDAK PKEARYILRT VLGRLRLGIA 

       190        200        210        220        230        240 
DMTILDALAA AFAGSKAARD VIERAYTKHP DLGYIAKLLA TKGLDAVASL KIEVGIPVLP 

       250        260        270        280        290        300 
MLAERLSDPA EILEKLGGKC LAEYKYDGER VQAHKSGDKV LLFSRRLENI THHYPDVVEY 

       310        320        330        340        350        360 
VKRLKVREAI VEGEIVAYNP DTGEMLPFQE LMHRRRKYDV EKAMKEYPVR VYLFDVIYMD 

       370        380        390        400        410        420 
GEELIEKPLD QRRLILEKIV PEGDEDILLS TAKVVGDAKD LLHFFEQAIS EGCEGVMCKS 

       430        440        450        460        470        480 
IGPGSIYQMG ARGWLWIKFK RDYRMEMTDT VDLVVVGGFH GRGKRAGTYG ALLMAAYDPE 

       490        500        510        520        530        540 
TDTFKTVCKV GTGFTDEDLA KLPELLDPYK IPHRHPRVFS KIEADVWFVP AVVLEIIGAE 

       550        560        570        580        590        600 
ITLSPLHTCA LNKLEEGAGL AIRFPRFTGR YRFDKKPEQA TTESELIEMY KSQKKTALQQ 


S 

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References

[1]"Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction."
Anderson I., Rodriguez J., Susanti D., Porat I., Reich C., Ulrich L.E., Elkins J.G., Mavromatis K., Lykidis A., Kim E., Thompson L.S., Nolan M., Land M., Copeland A., Lapidus A., Lucas S., Detter C., Zhulin I.B. expand/collapse author list , Olsen G.J., Whitman W., Mukhopadhyay B., Bristow J., Kyrpides N.
J. Bacteriol. 190:2957-2965(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Hrk 5.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000505 Genomic DNA. Translation: ABL78152.1.
RefSeqYP_920155.1. NC_008698.1.

3D structure databases

ProteinModelPortalA1RY72.
SMRA1RY72. Positions 7-595.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING368408.Tpen_0750.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABL78152; ABL78152; Tpen_0750.
GeneID4600401.
KEGGtpe:Tpen_0750.

Phylogenomic databases

eggNOGCOG1793.
HOGENOMHOG000036008.
KOK10747.
OMACTDIGEL.

Enzyme and pathway databases

BioCycTPEN368408:GHSG-797-MONOMER.

Family and domain databases

Gene3D1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPMF_00407. DNA_ligase.
InterProIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsTIGR00574. dnl1. 1 hit.
PROSITEPS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDNLI2_THEPD
AccessionPrimary (citable) accession number: A1RY72
Entry history
Integrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: February 6, 2007
Last modified: May 14, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families