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A1RY32

- TFE_THEPD

UniProt

A1RY32 - TFE_THEPD

Protein

Transcription factor E

Gene

tfe

Organism
Thermofilum pendens (strain Hrk 5)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 52 (01 Oct 2014)
      Sequence version 1 (06 Feb 2007)
      Previous versions | rss
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    Functioni

    Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes.UniRule annotation

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: InterPro

    GO - Biological processi

    1. DNA-templated transcription, initiation Source: UniProtKB-HAMAP
    2. regulation of transcription, DNA-templated Source: UniProtKB-HAMAP

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    BioCyciTPEN368408:GHSG-756-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transcription factor EUniRule annotation
    Short name:
    TFEUniRule annotation
    Alternative name(s):
    TFIIE subunit alpha homologUniRule annotation
    Transcription initiation factor TFIIEUniRule annotation
    Gene namesi
    Name:tfeUniRule annotation
    Ordered Locus Names:Tpen_0710
    OrganismiThermofilum pendens (strain Hrk 5)
    Taxonomic identifieri368408 [NCBI]
    Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiThermoprotealesThermofilaceaeThermofilum
    ProteomesiUP000000641: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 178178Transcription factor EPRO_0000326625Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer. Interaction with RNA polymerase subunits RpoF and RpoE is necessary for Tfe stimulatory transcription activity. Able to interact with Tbp and RNA polymerase in the absence of DNA promoter. Interacts both with the preinitiation and elongation complexes.UniRule annotation

    Protein-protein interaction databases

    STRINGi368408.Tpen_0710.

    Structurei

    3D structure databases

    ProteinModelPortaliA1RY32.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini3 – 8684HTH TFE/IIEalpha-typeUniRule annotationAdd
    BLAST

    Domaini

    The winged helix domain is involved in binding to DNA in the preinitiation complex.UniRule annotation

    Sequence similaritiesi

    Belongs to the TFE family.UniRule annotation
    Contains 1 HTH TFE/IIEalpha-type domain.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1675.
    KOiK03136.
    OMAiDSGWLTY.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    HAMAPiMF_01909. TFE_arch.
    InterProiIPR016481. TF_E_archaea.
    IPR017919. TFIIE/TFIIEa_HTH.
    IPR024550. TFIIEa/SarR/Rpc3_HTH_dom.
    IPR011991. WHTH_DNA-bd_dom.
    IPR013137. Znf_TFIIB.
    [Graphical view]
    PfamiPF08271. TF_Zn_Ribbon. 1 hit.
    PF02002. TFIIE_alpha. 1 hit.
    [Graphical view]
    PROSITEiPS51344. HTH_TFE_IIE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A1RY32-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNAHEALAEI AGKMFGDNAK KVMMVLASNV EVSDEDLAKD LKMDPPELRK    50
    LLNDLFEARL VKYRRARDEN IGWYKYYWRI TDEPIQQILS DRKRLTLSIL 100
    EKVLSLEENS ETYVCPKCGT RYTVDEAENN NYTCEVCGEV LEPFDNTHRV 150
    EKLKRAIELL GNWDPSPKQQ ASRAIPHA 178
    Length:178
    Mass (Da):20,575
    Last modified:February 6, 2007 - v1
    Checksum:i3515BAD4F3F757D8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000505 Genomic DNA. Translation: ABL78112.1.
    RefSeqiYP_920115.1. NC_008698.1.

    Genome annotation databases

    EnsemblBacteriaiABL78112; ABL78112; Tpen_0710.
    GeneIDi4601591.
    KEGGitpe:Tpen_0710.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000505 Genomic DNA. Translation: ABL78112.1 .
    RefSeqi YP_920115.1. NC_008698.1.

    3D structure databases

    ProteinModelPortali A1RY32.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 368408.Tpen_0710.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABL78112 ; ABL78112 ; Tpen_0710 .
    GeneIDi 4601591.
    KEGGi tpe:Tpen_0710.

    Phylogenomic databases

    eggNOGi COG1675.
    KOi K03136.
    OMAi DSGWLTY.

    Enzyme and pathway databases

    BioCyci TPEN368408:GHSG-756-MONOMER.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    HAMAPi MF_01909. TFE_arch.
    InterProi IPR016481. TF_E_archaea.
    IPR017919. TFIIE/TFIIEa_HTH.
    IPR024550. TFIIEa/SarR/Rpc3_HTH_dom.
    IPR011991. WHTH_DNA-bd_dom.
    IPR013137. Znf_TFIIB.
    [Graphical view ]
    Pfami PF08271. TF_Zn_Ribbon. 1 hit.
    PF02002. TFIIE_alpha. 1 hit.
    [Graphical view ]
    PROSITEi PS51344. HTH_TFE_IIE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Hrk 5.

    Entry informationi

    Entry nameiTFE_THEPD
    AccessioniPrimary (citable) accession number: A1RY32
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 8, 2008
    Last sequence update: February 6, 2007
    Last modified: October 1, 2014
    This is version 52 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3