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A1RY32

- TFE_THEPD

UniProt

A1RY32 - TFE_THEPD

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Protein
Transcription factor E
Gene
tfe, Tpen_0710
Organism
Thermofilum pendens (strain Hrk 5)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes By similarity.UniRule annotation

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro

GO - Biological processi

  1. DNA-templated transcription, initiation Source: UniProtKB-HAMAP
  2. regulation of transcription, DNA-templated Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciTPEN368408:GHSG-756-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor E
Short name:
TFE
Alternative name(s):
TFIIE subunit alpha homolog
Transcription initiation factor TFIIE
Gene namesi
Name:tfe
Ordered Locus Names:Tpen_0710
OrganismiThermofilum pendens (strain Hrk 5)
Taxonomic identifieri368408 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiThermoprotealesThermofilaceaeThermofilum
ProteomesiUP000000641: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 178178Transcription factor EUniRule annotation
PRO_0000326625Add
BLAST

Interactioni

Subunit structurei

Monomer By similarity. Interaction with RNA polymerase subunits RpoF and RpoE is necessary for Tfe stimulatory transcription activity. Able to interact with Tbp and RNA polymerase in the absence of DNA promoter. Interacts both with the preinitiation and elongation complexes By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi368408.Tpen_0710.

Structurei

3D structure databases

ProteinModelPortaliA1RY32.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 8684HTH TFE/IIEalpha-type
Add
BLAST

Domaini

The winged helix domain is involved in binding to DNA in the preinitiation complex By similarity.UniRule annotation

Sequence similaritiesi

Belongs to the TFE family.

Phylogenomic databases

eggNOGiCOG1675.
KOiK03136.
OMAiDSGWLTY.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
HAMAPiMF_01909. TFE_arch.
InterProiIPR016481. TF_E_archaea.
IPR017919. TFIIE/TFIIEa_HTH.
IPR024550. TFIIEa/SarR/Rpc3_HTH_dom.
IPR011991. WHTH_DNA-bd_dom.
IPR013137. Znf_TFIIB.
[Graphical view]
PfamiPF08271. TF_Zn_Ribbon. 1 hit.
PF02002. TFIIE_alpha. 1 hit.
[Graphical view]
PROSITEiPS51344. HTH_TFE_IIE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1RY32-1 [UniParc]FASTAAdd to Basket

« Hide

MNAHEALAEI AGKMFGDNAK KVMMVLASNV EVSDEDLAKD LKMDPPELRK    50
LLNDLFEARL VKYRRARDEN IGWYKYYWRI TDEPIQQILS DRKRLTLSIL 100
EKVLSLEENS ETYVCPKCGT RYTVDEAENN NYTCEVCGEV LEPFDNTHRV 150
EKLKRAIELL GNWDPSPKQQ ASRAIPHA 178
Length:178
Mass (Da):20,575
Last modified:February 6, 2007 - v1
Checksum:i3515BAD4F3F757D8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000505 Genomic DNA. Translation: ABL78112.1.
RefSeqiYP_920115.1. NC_008698.1.

Genome annotation databases

EnsemblBacteriaiABL78112; ABL78112; Tpen_0710.
GeneIDi4601591.
KEGGitpe:Tpen_0710.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000505 Genomic DNA. Translation: ABL78112.1 .
RefSeqi YP_920115.1. NC_008698.1.

3D structure databases

ProteinModelPortali A1RY32.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 368408.Tpen_0710.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABL78112 ; ABL78112 ; Tpen_0710 .
GeneIDi 4601591.
KEGGi tpe:Tpen_0710.

Phylogenomic databases

eggNOGi COG1675.
KOi K03136.
OMAi DSGWLTY.

Enzyme and pathway databases

BioCyci TPEN368408:GHSG-756-MONOMER.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
HAMAPi MF_01909. TFE_arch.
InterProi IPR016481. TF_E_archaea.
IPR017919. TFIIE/TFIIEa_HTH.
IPR024550. TFIIEa/SarR/Rpc3_HTH_dom.
IPR011991. WHTH_DNA-bd_dom.
IPR013137. Znf_TFIIB.
[Graphical view ]
Pfami PF08271. TF_Zn_Ribbon. 1 hit.
PF02002. TFIIE_alpha. 1 hit.
[Graphical view ]
PROSITEi PS51344. HTH_TFE_IIE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Hrk 5.

Entry informationi

Entry nameiTFE_THEPD
AccessioniPrimary (citable) accession number: A1RY32
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: February 6, 2007
Last modified: February 19, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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