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A1RXY1

- A1RXY1_THEPD

UniProt

A1RXY1 - A1RXY1_THEPD

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Protein
Histidine--tRNA ligase
Gene
hisS, Tpen_0659
Organism
Thermofilum pendens (strain Hrk 5)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His).UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. histidine-tRNA ligase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. histidine biosynthetic process Source: InterPro
  2. histidyl-tRNA aminoacylation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetaseUniRule annotationImported, Ligase

Keywords - Biological processi

Protein biosynthesisUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciTPEN368408:GHSG-701-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidine--tRNA ligaseUniRule annotation (EC:6.1.1.21UniRule annotation)
Alternative name(s):
Histidyl-tRNA synthetase
Gene namesi
Name:hisSUniRule annotation
Ordered Locus Names:Tpen_0659Imported
OrganismiThermofilum pendens (strain Hrk 5)Imported
Taxonomic identifieri368408 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiThermoprotealesThermofilaceaeThermofilum
ProteomesiUP000000641: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi368408.Tpen_0659.

Structurei

3D structure databases

ProteinModelPortaliA1RXY1.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0124.
HOGENOMiHOG000018073.
KOiK01892.
OMAiMEQYCEL.

Family and domain databases

Gene3Di3.40.50.800. 1 hit.
HAMAPiMF_00125. HisZ.
MF_00127. His_tRNA_synth.
InterProiIPR006195. aa-tRNA-synth_II.
IPR004154. Anticodon-bd.
IPR015807. His-tRNA-ligase.
IPR004516. HisRS/HisZ.
IPR004517. HisZ.
[Graphical view]
PANTHERiPTHR11476. PTHR11476. 1 hit.
PfamiPF03129. HGTP_anticodon. 1 hit.
[Graphical view]
PIRSFiPIRSF001549. His-tRNA_synth. 1 hit.
SUPFAMiSSF52954. SSF52954. 1 hit.
TIGRFAMsiTIGR00442. hisS. 1 hit.
PROSITEiPS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1RXY1-1 [UniParc]FASTAAdd to Basket

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MSKNLVLQPP RGTRDWLPEE AYAKRIVSEK IREVFESYGY GEVITPAFEY    50
LDLLKAKAGE EVVEQIYAFK DKAGRELGLR FEMTTPIARI VASRLDLAKP 100
LRFYYVQPVW RYEEPQRGRW REFWQAGIEL FGISEPEGDA EVVAVTFDAL 150
KAVGLKDFDI RVNDRRVVED LVLGAGIPGD LLPSALRVLD KMDKFGEEYV 200
VSELAKLGLR EDAATSLLEK LKSGSLDIDT STQPGREGLR RLALVVDTLK 250
NCYGINVTVD YAIVRGLGYY TGFVFEVKAG SSEGLGSIAG GGRYDDLVSV 300
VGGPKIPASG MAIGVERLLE ALSMQGALKL DYREVDVCVI PVKKTPEILS 350
EAVAVARELR VAGMKVVLEV SERSLSKLLE AASKRGARFA IILGERELKE 400
GVVTVRDLYL WKEEKVARPH LYEYIRAGSS T 431
Length:431
Mass (Da):47,831
Last modified:February 6, 2007 - v1
Checksum:i4751AF58A52657A9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000505 Genomic DNA. Translation: ABL78061.1.
RefSeqiWP_011752326.1. NC_008698.1.
YP_920064.1. NC_008698.1.

Genome annotation databases

EnsemblBacteriaiABL78061; ABL78061; Tpen_0659.
GeneIDi4601617.
KEGGitpe:Tpen_0659.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000505 Genomic DNA. Translation: ABL78061.1 .
RefSeqi WP_011752326.1. NC_008698.1.
YP_920064.1. NC_008698.1.

3D structure databases

ProteinModelPortali A1RXY1.
ModBasei Search...

Protein-protein interaction databases

STRINGi 368408.Tpen_0659.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABL78061 ; ABL78061 ; Tpen_0659 .
GeneIDi 4601617.
KEGGi tpe:Tpen_0659.

Phylogenomic databases

eggNOGi COG0124.
HOGENOMi HOG000018073.
KOi K01892.
OMAi MEQYCEL.

Enzyme and pathway databases

BioCyci TPEN368408:GHSG-701-MONOMER.

Family and domain databases

Gene3Di 3.40.50.800. 1 hit.
HAMAPi MF_00125. HisZ.
MF_00127. His_tRNA_synth.
InterProi IPR006195. aa-tRNA-synth_II.
IPR004154. Anticodon-bd.
IPR015807. His-tRNA-ligase.
IPR004516. HisRS/HisZ.
IPR004517. HisZ.
[Graphical view ]
PANTHERi PTHR11476. PTHR11476. 1 hit.
Pfami PF03129. HGTP_anticodon. 1 hit.
[Graphical view ]
PIRSFi PIRSF001549. His-tRNA_synth. 1 hit.
SUPFAMi SSF52954. SSF52954. 1 hit.
TIGRFAMsi TIGR00442. hisS. 1 hit.
PROSITEi PS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Hrk 5.

Entry informationi

Entry nameiA1RXY1_THEPD
AccessioniPrimary (citable) accession number: A1RXY1
Entry historyi
Integrated into UniProtKB/TrEMBL: February 6, 2007
Last sequence update: February 6, 2007
Last modified: September 3, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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