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A1RXY1

- A1RXY1_THEPD

UniProt

A1RXY1 - A1RXY1_THEPD

Protein

Histidine--tRNA ligase

Gene

hisS

Organism
Thermofilum pendens (strain Hrk 5)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 1 (06 Feb 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His).UniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. histidine-tRNA ligase activity Source: UniProtKB-EC

    GO - Biological processi

    1. histidine biosynthetic process Source: InterPro
    2. histidyl-tRNA aminoacylation Source: InterPro

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetaseUniRule annotationImported, Ligase

    Keywords - Biological processi

    Protein biosynthesisUniRule annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotation, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciTPEN368408:GHSG-701-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histidine--tRNA ligaseUniRule annotation (EC:6.1.1.21UniRule annotation)
    Alternative name(s):
    Histidyl-tRNA synthetaseUniRule annotation
    Gene namesi
    Name:hisSUniRule annotation
    Ordered Locus Names:Tpen_0659Imported
    OrganismiThermofilum pendens (strain Hrk 5)Imported
    Taxonomic identifieri368408 [NCBI]
    Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiThermoprotealesThermofilaceaeThermofilum
    ProteomesiUP000000641: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotation

    Interactioni

    Protein-protein interaction databases

    STRINGi368408.Tpen_0659.

    Structurei

    3D structure databases

    ProteinModelPortaliA1RXY1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the class-II aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0124.
    HOGENOMiHOG000018073.
    KOiK01892.
    OMAiMEQYCEL.

    Family and domain databases

    Gene3Di3.40.50.800. 1 hit.
    HAMAPiMF_00125. HisZ.
    MF_00127. His_tRNA_synth.
    InterProiIPR006195. aa-tRNA-synth_II.
    IPR004154. Anticodon-bd.
    IPR015807. His-tRNA-ligase.
    IPR004516. HisRS/HisZ.
    IPR004517. HisZ.
    [Graphical view]
    PANTHERiPTHR11476. PTHR11476. 1 hit.
    PfamiPF03129. HGTP_anticodon. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001549. His-tRNA_synth. 1 hit.
    SUPFAMiSSF52954. SSF52954. 1 hit.
    TIGRFAMsiTIGR00442. hisS. 1 hit.
    PROSITEiPS50862. AA_TRNA_LIGASE_II. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A1RXY1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSKNLVLQPP RGTRDWLPEE AYAKRIVSEK IREVFESYGY GEVITPAFEY    50
    LDLLKAKAGE EVVEQIYAFK DKAGRELGLR FEMTTPIARI VASRLDLAKP 100
    LRFYYVQPVW RYEEPQRGRW REFWQAGIEL FGISEPEGDA EVVAVTFDAL 150
    KAVGLKDFDI RVNDRRVVED LVLGAGIPGD LLPSALRVLD KMDKFGEEYV 200
    VSELAKLGLR EDAATSLLEK LKSGSLDIDT STQPGREGLR RLALVVDTLK 250
    NCYGINVTVD YAIVRGLGYY TGFVFEVKAG SSEGLGSIAG GGRYDDLVSV 300
    VGGPKIPASG MAIGVERLLE ALSMQGALKL DYREVDVCVI PVKKTPEILS 350
    EAVAVARELR VAGMKVVLEV SERSLSKLLE AASKRGARFA IILGERELKE 400
    GVVTVRDLYL WKEEKVARPH LYEYIRAGSS T 431
    Length:431
    Mass (Da):47,831
    Last modified:February 6, 2007 - v1
    Checksum:i4751AF58A52657A9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000505 Genomic DNA. Translation: ABL78061.1.
    RefSeqiWP_011752326.1. NC_008698.1.
    YP_920064.1. NC_008698.1.

    Genome annotation databases

    EnsemblBacteriaiABL78061; ABL78061; Tpen_0659.
    GeneIDi4601617.
    KEGGitpe:Tpen_0659.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000505 Genomic DNA. Translation: ABL78061.1 .
    RefSeqi WP_011752326.1. NC_008698.1.
    YP_920064.1. NC_008698.1.

    3D structure databases

    ProteinModelPortali A1RXY1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 368408.Tpen_0659.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABL78061 ; ABL78061 ; Tpen_0659 .
    GeneIDi 4601617.
    KEGGi tpe:Tpen_0659.

    Phylogenomic databases

    eggNOGi COG0124.
    HOGENOMi HOG000018073.
    KOi K01892.
    OMAi MEQYCEL.

    Enzyme and pathway databases

    BioCyci TPEN368408:GHSG-701-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.800. 1 hit.
    HAMAPi MF_00125. HisZ.
    MF_00127. His_tRNA_synth.
    InterProi IPR006195. aa-tRNA-synth_II.
    IPR004154. Anticodon-bd.
    IPR015807. His-tRNA-ligase.
    IPR004516. HisRS/HisZ.
    IPR004517. HisZ.
    [Graphical view ]
    PANTHERi PTHR11476. PTHR11476. 1 hit.
    Pfami PF03129. HGTP_anticodon. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001549. His-tRNA_synth. 1 hit.
    SUPFAMi SSF52954. SSF52954. 1 hit.
    TIGRFAMsi TIGR00442. hisS. 1 hit.
    PROSITEi PS50862. AA_TRNA_LIGASE_II. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Hrk 5Imported.

    Entry informationi

    Entry nameiA1RXY1_THEPD
    AccessioniPrimary (citable) accession number: A1RXY1
    Entry historyi
    Integrated into UniProtKB/TrEMBL: February 6, 2007
    Last sequence update: February 6, 2007
    Last modified: October 1, 2014
    This is version 61 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3