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Protein

Histidine--tRNA ligase

Gene

hisS

Organism
Thermofilum pendens (strain DSM 2475 / Hrk 5)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetaseUniRule annotationImported, Ligase
Biological processProtein biosynthesisUniRule annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Histidine--tRNA ligaseUniRule annotation (EC:6.1.1.21UniRule annotation)
Alternative name(s):
Histidyl-tRNA synthetaseUniRule annotation
Short name:
HisRSUniRule annotation
Gene namesi
Name:hisSUniRule annotation
Ordered Locus Names:Tpen_0659Imported
OrganismiThermofilum pendens (strain DSM 2475 / Hrk 5)Imported
Taxonomic identifieri368408 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiThermoprotealesThermofilaceaeThermofilum
Proteomesi
  • UP000000641 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi368408.Tpen_0659.

Structurei

3D structure databases

ProteinModelPortaliA1RXY1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 341AA_TRNA_LIGASE_IIInterPro annotationAdd BLAST331

Sequence similaritiesi

Belongs to the class-II aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00404. Archaea.
COG0124. LUCA.
HOGENOMiHOG000018073.
KOiK01892.
OMAiCDFDFIG.
OrthoDBiPOG093Z03IG.

Family and domain databases

Gene3Di3.40.50.800. 1 hit.
HAMAPiMF_00127. His_tRNA_synth. 1 hit.
MF_00125. HisZ. 1 hit.
InterProiView protein in InterPro
IPR006195. aa-tRNA-synth_II.
IPR004154. Anticodon-bd.
IPR015807. His-tRNA-ligase.
IPR004516. HisRS/HisZ.
IPR004517. HisZ.
PANTHERiPTHR43707. PTHR43707. 1 hit.
PfamiView protein in Pfam
PF03129. HGTP_anticodon. 1 hit.
PIRSFiPIRSF001549. His-tRNA_synth. 1 hit.
SUPFAMiSSF52954. SSF52954. 1 hit.
TIGRFAMsiTIGR00442. hisS. 1 hit.
PROSITEiView protein in PROSITE
PS50862. AA_TRNA_LIGASE_II. 1 hit.

Sequencei

Sequence statusi: Complete.

A1RXY1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKNLVLQPP RGTRDWLPEE AYAKRIVSEK IREVFESYGY GEVITPAFEY
60 70 80 90 100
LDLLKAKAGE EVVEQIYAFK DKAGRELGLR FEMTTPIARI VASRLDLAKP
110 120 130 140 150
LRFYYVQPVW RYEEPQRGRW REFWQAGIEL FGISEPEGDA EVVAVTFDAL
160 170 180 190 200
KAVGLKDFDI RVNDRRVVED LVLGAGIPGD LLPSALRVLD KMDKFGEEYV
210 220 230 240 250
VSELAKLGLR EDAATSLLEK LKSGSLDIDT STQPGREGLR RLALVVDTLK
260 270 280 290 300
NCYGINVTVD YAIVRGLGYY TGFVFEVKAG SSEGLGSIAG GGRYDDLVSV
310 320 330 340 350
VGGPKIPASG MAIGVERLLE ALSMQGALKL DYREVDVCVI PVKKTPEILS
360 370 380 390 400
EAVAVARELR VAGMKVVLEV SERSLSKLLE AASKRGARFA IILGERELKE
410 420 430
GVVTVRDLYL WKEEKVARPH LYEYIRAGSS T
Length:431
Mass (Da):47,831
Last modified:February 6, 2007 - v1
Checksum:i4751AF58A52657A9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000505 Genomic DNA. Translation: ABL78061.1.
RefSeqiWP_011752326.1. NC_008698.1.

Genome annotation databases

EnsemblBacteriaiABL78061; ABL78061; Tpen_0659.
GeneIDi4601617.
KEGGitpe:Tpen_0659.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiA1RXY1_THEPD
AccessioniPrimary (citable) accession number: A1RXY1
Entry historyiIntegrated into UniProtKB/TrEMBL: February 6, 2007
Last sequence update: February 6, 2007
Last modified: June 7, 2017
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported