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Protein

DNA polymerase sliding clamp

Gene

pcn

Organism
Thermofilum pendens (strain DSM 2475 / Hrk 5)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processDNA replication

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymerase sliding clampUniRule annotation
Alternative name(s):
Proliferating cell nuclear antigen homologUniRule annotation
Short name:
PCNAUniRule annotation
Gene namesi
Name:pcnUniRule annotation
Ordered Locus Names:Tpen_0624
OrganismiThermofilum pendens (strain DSM 2475 / Hrk 5)
Taxonomic identifieri368408 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiThermoprotealesThermofilaceaeThermofilum
Proteomesi
  • UP000000641 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000720031 – 247DNA polymerase sliding clampAdd BLAST247

Interactioni

Subunit structurei

Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.UniRule annotation

Protein-protein interaction databases

STRINGi368408.Tpen_0624

Structurei

3D structure databases

ProteinModelPortaliA1RXU8
SMRiA1RXU8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PCNA family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00488 Archaea
COG0592 LUCA
HOGENOMiHOG000222371
KOiK04802
OMAiKCANSDD
OrthoDBiPOG093Z0814

Family and domain databases

HAMAPiMF_00317 DNApol_clamp_arch, 1 hit
InterProiView protein in InterPro
IPR000730 Pr_cel_nuc_antig
IPR022649 Pr_cel_nuc_antig_C
IPR022648 Pr_cel_nuc_antig_N
PANTHERiPTHR11352:SF0 PTHR11352:SF0, 1 hit
PfamiView protein in Pfam
PF02747 PCNA_C, 1 hit
PF00705 PCNA_N, 1 hit
PRINTSiPR00339 PCNACYCLIN
TIGRFAMsiTIGR00590 pcna, 1 hit

Sequencei

Sequence statusi: Complete.

A1RXU8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVKFVFPDAR EWKYIIESLA TIVDEANFVA SPEGLKLRAL DPGRIAMVDL
60 70 80 90 100
FIPSNLFEEY SVDQETKISA VLDDIDKVLK RAKSDDKISF EVSQGRLIIT
110 120 130 140 150
LSGRAERRFK FPLIDIAGQE LPSPKLNFTV AAKMLSDTFR DALKDASLVS
160 170 180 190 200
ESVKLKAEDE SLWLLARSDK GEIESRFSIE TGSLVEIDVK EAAEASYGID
210 220 230 240
FLDKIVSKAY RISDILGLRF ATNMPLEMTF DIAGGGTLKY LLAPRME
Length:247
Mass (Da):27,583
Last modified:February 6, 2007 - v1
Checksum:i8330327D2CBC98C1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000505 Genomic DNA Translation: ABL78028.1
RefSeqiWP_011752293.1, NC_008698.1

Genome annotation databases

EnsemblBacteriaiABL78028; ABL78028; Tpen_0624
GeneIDi4601411
KEGGitpe:Tpen_0624

Similar proteinsi

Entry informationi

Entry nameiPCNA_THEPD
AccessioniPrimary (citable) accession number: A1RXU8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 6, 2007
Last modified: March 28, 2018
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health