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A1RXU2

- MTAP_THEPD

UniProt

A1RXU2 - MTAP_THEPD

Protein

S-methyl-5'-thioadenosine phosphorylase

Gene

mtnP

Organism
Thermofilum pendens (strain Hrk 5)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 46 (01 Oct 2014)
      Sequence version 1 (06 Feb 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.UniRule annotation

    Catalytic activityi

    S-methyl-5'-thioadenosine + phosphate = adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei12 – 121PhosphateUniRule annotation
    Sitei167 – 1671Important for substrate specificityUniRule annotation
    Binding sitei185 – 1851Substrate; via amide nitrogenUniRule annotation
    Binding sitei186 – 1861PhosphateUniRule annotation
    Sitei220 – 2201Important for substrate specificityUniRule annotation

    GO - Molecular functioni

    1. phosphorylase activity Source: InterPro
    2. S-methyl-5-thioadenosine phosphorylase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. L-methionine biosynthetic process from methylthioadenosine Source: UniProtKB-HAMAP
    2. purine ribonucleoside salvage Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Purine salvage

    Enzyme and pathway databases

    BioCyciTPEN368408:GHSG-657-MONOMER.
    UniPathwayiUPA00904; UER00873.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    S-methyl-5'-thioadenosine phosphorylaseUniRule annotation (EC:2.4.2.28UniRule annotation)
    Alternative name(s):
    5'-methylthioadenosine phosphorylaseUniRule annotation
    Short name:
    MTA phosphorylaseUniRule annotation
    Short name:
    MTAPUniRule annotation
    Gene namesi
    Name:mtnPUniRule annotation
    Ordered Locus Names:Tpen_0618
    OrganismiThermofilum pendens (strain Hrk 5)
    Taxonomic identifieri368408 [NCBI]
    Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiThermoprotealesThermofilaceaeThermofilum
    ProteomesiUP000000641: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 262262S-methyl-5'-thioadenosine phosphorylasePRO_0000415110Add
    BLAST

    Interactioni

    Subunit structurei

    Homohexamer. Dimer of a homotrimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi368408.Tpen_0618.

    Structurei

    3D structure databases

    ProteinModelPortaliA1RXU2.
    SMRiA1RXU2. Positions 2-262.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni54 – 552Phosphate bindingUniRule annotation
    Regioni87 – 882Phosphate bindingUniRule annotation
    Regioni209 – 2113Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0005.
    HOGENOMiHOG000228987.
    KOiK00772.
    OMAiDYTFYNG.

    Family and domain databases

    Gene3Di3.40.50.1580. 1 hit.
    HAMAPiMF_01963. MTAP.
    InterProiIPR010044. MTAP.
    IPR000845. Nucleoside_phosphorylase_d.
    IPR001369. PNP/MTAP.
    IPR018099. Purine_phosphorylase-2_CS.
    [Graphical view]
    PANTHERiPTHR11904. PTHR11904. 1 hit.
    PfamiPF01048. PNP_UDP_1. 1 hit.
    [Graphical view]
    SUPFAMiSSF53167. SSF53167. 1 hit.
    TIGRFAMsiTIGR01694. MTAP. 1 hit.
    PROSITEiPS01240. PNP_MTAP_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A1RXU2-1 [UniParc]FASTAAdd to Basket

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    MEKVKIGIIG GSGLYSPDFL TNPKEEKIYT PYGPPSSHVV IGEIAGRKVA    50
    FIPRHGKRHE IPPHKVNYRA NIYALKELGV ERLISVSAVG SLREDYKPGD 100
    FVCTDQFIDM TKGRVYTFYD GPVVAHVSMA DPFCPELREL CIRSARKLGI 150
    TMHEKGTYIC IEGPRFSTRA ESRLWRQFGA DIIGMTLVPE VNLAREARMC 200
    FLNIAMVTDY DVWAEKPVTA HEVARVMAEN TEKVKRLLAD LIPSIPEERK 250
    CQCARALDEA LI 262
    Length:262
    Mass (Da):29,467
    Last modified:February 6, 2007 - v1
    Checksum:i0805BD30C4FB86E6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000505 Genomic DNA. Translation: ABL78022.1.
    RefSeqiWP_011752287.1. NC_008698.1.
    YP_920025.1. NC_008698.1.

    Genome annotation databases

    EnsemblBacteriaiABL78022; ABL78022; Tpen_0618.
    GeneIDi4601324.
    KEGGitpe:Tpen_0618.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000505 Genomic DNA. Translation: ABL78022.1 .
    RefSeqi WP_011752287.1. NC_008698.1.
    YP_920025.1. NC_008698.1.

    3D structure databases

    ProteinModelPortali A1RXU2.
    SMRi A1RXU2. Positions 2-262.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 368408.Tpen_0618.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABL78022 ; ABL78022 ; Tpen_0618 .
    GeneIDi 4601324.
    KEGGi tpe:Tpen_0618.

    Phylogenomic databases

    eggNOGi COG0005.
    HOGENOMi HOG000228987.
    KOi K00772.
    OMAi DYTFYNG.

    Enzyme and pathway databases

    UniPathwayi UPA00904 ; UER00873 .
    BioCyci TPEN368408:GHSG-657-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.1580. 1 hit.
    HAMAPi MF_01963. MTAP.
    InterProi IPR010044. MTAP.
    IPR000845. Nucleoside_phosphorylase_d.
    IPR001369. PNP/MTAP.
    IPR018099. Purine_phosphorylase-2_CS.
    [Graphical view ]
    PANTHERi PTHR11904. PTHR11904. 1 hit.
    Pfami PF01048. PNP_UDP_1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53167. SSF53167. 1 hit.
    TIGRFAMsi TIGR01694. MTAP. 1 hit.
    PROSITEi PS01240. PNP_MTAP_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Hrk 5.

    Entry informationi

    Entry nameiMTAP_THEPD
    AccessioniPrimary (citable) accession number: A1RXU2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 25, 2012
    Last sequence update: February 6, 2007
    Last modified: October 1, 2014
    This is version 46 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3