SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

A1RXJ9

- A1RXJ9_THEPD

UniProt

A1RXJ9 - A1RXJ9_THEPD

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
NAD kinase
Gene
nadK, Tpen_0523
Organism
Thermofilum pendens (strain Hrk 5)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP By similarity.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

Divalent metal ions By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei67 – 671Proton acceptor By similarityUniRule annotation
Binding sitei72 – 721NAD By similarityUniRule annotation
Binding sitei163 – 1631NAD By similarityUniRule annotation
Binding sitei165 – 1651NAD By similarityUniRule annotation
Binding sitei173 – 1731NAD; via carbonyl oxygen By similarityUniRule annotation
Binding sitei233 – 2331NAD By similarityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi67 – 682NAD By similarityUniRule annotation
Nucleotide bindingi136 – 1372NAD By similarityUniRule annotation
Nucleotide bindingi176 – 1816NAD By similarityUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. NAD+ kinase activity Source: UniProtKB-HAMAP
  3. metal ion binding Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. NAD metabolic process Source: InterPro
  2. NADP biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationImported, Transferase

Keywords - Ligandi

ATP-bindingUniRule annotation, NADUniRule annotation, NADPUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciTPEN368408:GHSG-551-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
Alternative name(s):
ATP-dependent NAD kinase
Gene namesi
Name:nadKUniRule annotation
Ordered Locus Names:Tpen_0523Imported
OrganismiThermofilum pendens (strain Hrk 5)Imported
Taxonomic identifieri368408 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiThermoprotealesThermofilaceaeThermofilum
ProteomesiUP000000641: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi368408.Tpen_0523.

Structurei

3D structure databases

ProteinModelPortaliA1RXJ9.

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0061.
KOiK00858.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase.
InterProiIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view]
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.

Sequencei

Sequence statusi: Complete.

A1RXJ9-1 [UniParc]FASTAAdd to Basket

« Hide

MSFRKVWMKA RANDPVVLEH ARLLYRYLTD RGLDVYVDPL LGHVIPGRSL    50
SELEAREADL GIVVGGDGTL LRTVQKSNAV LPPILGFSSD SLGYLLPHRV 100
DVAREVLEEV LRGNYSERDV ALGEFIAGER AGVFLNEVCV WSEPGKIVEF 150
EVLLNDESLY RVRGDGVIVA TPAGSTGHAF SYGGPVIIDT GQRALEVVFP 200
GALSPLIRPL IVHGGSIAVK VIAHPANLVV DGQVYSKLQE ASKVTVRPSS 250
KSLRFIYVEK YETPLPEKLA RRVLDRGLSY VVSSLFKQTP KP 292
Length:292
Mass (Da):31,982
Last modified:February 6, 2007 - v1
Checksum:iE251C2D1A4BF2159
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000505 Genomic DNA. Translation: ABL77929.1.
RefSeqiYP_919932.1. NC_008698.1.

Genome annotation databases

EnsemblBacteriaiABL77929; ABL77929; Tpen_0523.
GeneIDi4601340.
KEGGitpe:Tpen_0523.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000505 Genomic DNA. Translation: ABL77929.1 .
RefSeqi YP_919932.1. NC_008698.1.

3D structure databases

ProteinModelPortali A1RXJ9.
ModBasei Search...

Protein-protein interaction databases

STRINGi 368408.Tpen_0523.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABL77929 ; ABL77929 ; Tpen_0523 .
GeneIDi 4601340.
KEGGi tpe:Tpen_0523.

Phylogenomic databases

eggNOGi COG0061.
KOi K00858.

Enzyme and pathway databases

BioCyci TPEN368408:GHSG-551-MONOMER.

Family and domain databases

Gene3Di 2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPi MF_00361. NAD_kinase.
InterProi IPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view ]
PANTHERi PTHR20275. PTHR20275. 1 hit.
Pfami PF01513. NAD_kinase. 1 hit.
[Graphical view ]
SUPFAMi SSF111331. SSF111331. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Hrk 5.

Entry informationi

Entry nameiA1RXJ9_THEPD
AccessioniPrimary (citable) accession number: A1RXJ9
Entry historyi
Integrated into UniProtKB/TrEMBL: February 6, 2007
Last sequence update: February 6, 2007
Last modified: July 9, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

Similar proteinsi