A1RXJ9 (A1RXJ9_THEPD) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Probable inorganic polyphosphate/ATP-NAD kinase HAMAP-Rule MF_00361
Short name=Poly(P)/ATP NAD kinase HAMAP-Rule MF_00361
EC=2.7.1.23 HAMAP-Rule MF_00361

Gene names

Name:	ppnK HAMAP-Rule MF_00361
Ordered Locus Names:	Tpen_0523 EMBL ABL77929.1

Organism

Thermofilum pendens (strain Hrk 5) [Reference proteome] [HAMAP] EMBL ABL77929.1

Taxonomic identifier

368408 [NCBI]

Taxonomic lineage

cellular organisms › Archaea › Crenarchaeota › Thermoprotei › Thermoproteales › Thermofilaceae › Thermofilum › Thermofilum pendens

Protein attributes

Sequence length	292 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus By similarity. HAMAP-Rule MF_00361
Catalytic activity	ATP + NAD+ = ADP + NADP+. HAMAP-Rule MF_00361
Cofactor	Divalent metal ions By similarity. HAMAP-Rule MF_00361
Subcellular location	Cytoplasm By similarity HAMAP-Rule MF_00361.
Sequence similarities	Belongs to the NAD kinase family. HAMAP-Rule MF_00361

Ontologies

Keywords
Cellular component	Cytoplasm HAMAP-Rule MF_00361
Ligand	ATP-binding HAMAP-Rule MF_00361 NAD HAMAP-Rule MF_00361 NADP HAMAP-Rule MF_00361 Nucleotide-binding
Molecular function	Kinase HAMAP-Rule MF_00361 EMBL ABL77929.1 Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	NAD metabolic process Inferred from electronic annotation. Source: InterPro NADP biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW NAD+ kinase activity Inferred from electronic annotation. Source: HAMAP metal ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A1RXJ9 [UniParc]. Last modified February 6, 2007. Version 1. Checksum: E251C2D1A4BF2159	FASTA	292	31,982
	10 20 30 40 50 60 MSFRKVWMKA RANDPVVLEH ARLLYRYLTD RGLDVYVDPL LGHVIPGRSL SELEAREADL 70 80 90 100 110 120 GIVVGGDGTL LRTVQKSNAV LPPILGFSSD SLGYLLPHRV DVAREVLEEV LRGNYSERDV 130 140 150 160 170 180 ALGEFIAGER AGVFLNEVCV WSEPGKIVEF EVLLNDESLY RVRGDGVIVA TPAGSTGHAF 190 200 210 220 230 240 SYGGPVIIDT GQRALEVVFP GALSPLIRPL IVHGGSIAVK VIAHPANLVV DGQVYSKLQE 250 260 270 280 290 ASKVTVRPSS KSLRFIYVEK YETPLPEKLA RRVLDRGLSY VVSSLFKQTP KP

References

[1]

"Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction." Anderson I., Rodriguez J., Susanti D., Porat I., Reich C., Ulrich L.E., Elkins J.G., Mavromatis K., Lykidis A., Kim E., Thompson L.S., Nolan M., Land M., Copeland A., Lapidus A., Lucas S., Detter C., Zhulin I.B. , Olsen G.J., Whitman W., Mukhopadhyay B., Bristow J., Kyrpides N. J. Bacteriol. 190:2957-2965(2008) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Hrk 5.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000505 Genomic DNA. Translation: ABL77929.1.
RefSeq	YP_919932.1. NC_008698.1.
3D structure databases
ProteinModelPortal	A1RXJ9.
ModBase	Search...
Protein-protein interaction databases
STRING	368408.Tpen_0523.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABL77929; ABL77929; Tpen_0523.
GeneID	4601340.
KEGG	tpe:Tpen_0523.
Phylogenomic databases
eggNOG	COG0061.
KO	K00858.
OMA	ELPSALN.
Family and domain databases
Gene3D	2.60.200.30. 1 hit. 3.40.50.10330. 1 hit.
HAMAP	MF_00361. NAD_kinase.
InterPro	IPR017438. ATP-NAD_kinase_dom_1. IPR016064. ATP-NAD_kinase_PpnK-typ. IPR017437. ATP-NAD_kinase_PpnK-typ_all-b. IPR002504. PolyP/ATP_NADK_prd. [Graphical view]
PANTHER	PTHR20275. PTHR20275. 1 hit.
Pfam	PF01513. NAD_kinase. 1 hit. [Graphical view]
SUPFAM	SSF111331. ATP-NAD_kinase_PpnK-typ. 1 hit.
ProtoNet	Search...

Entry information

Entry name

A1RXJ9_THEPD

Accession

Primary (citable) accession number: A1RXJ9

Entry history

Integrated into UniProtKB/TrEMBL:	February 6, 2007
Last sequence update:	February 6, 2007
Last modified:	May 1, 2013
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)