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Protein

NAD kinase

Gene

nadK

Organism
Thermofilum pendens (strain Hrk 5)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

a divalent metal cationUniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei67 – 671Proton acceptorUniRule annotation
Binding sitei72 – 721NADUniRule annotation
Binding sitei163 – 1631NADUniRule annotation
Binding sitei165 – 1651NADUniRule annotation
Binding sitei173 – 1731NAD; via carbonyl oxygenUniRule annotation
Binding sitei233 – 2331NADUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi67 – 682NADUniRule annotation
Nucleotide bindingi136 – 1372NADUniRule annotation
Nucleotide bindingi176 – 1816NADUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationImported, Transferase

Keywords - Ligandi

ATP-bindingUniRule annotation, NADUniRule annotation, NADPUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciTPEN368408:GHSG-551-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
Alternative name(s):
ATP-dependent NAD kinaseUniRule annotation
Gene namesi
Name:nadKUniRule annotation
Ordered Locus Names:Tpen_0523Imported
OrganismiThermofilum pendens (strain Hrk 5)Imported
Taxonomic identifieri368408 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiThermoprotealesThermofilaceaeThermofilum
ProteomesiUP000000641 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi368408.Tpen_0523.

Structurei

3D structure databases

ProteinModelPortaliA1RXJ9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0061.
KOiK00858.
OMAiGINWGEV.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase.
InterProiIPR017438. ATP-NAD_kinase_dom_1.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR016064. NAD/diacylglycerol_kinase.
IPR002504. NADK.
[Graphical view]
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.

Sequencei

Sequence statusi: Complete.

A1RXJ9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFRKVWMKA RANDPVVLEH ARLLYRYLTD RGLDVYVDPL LGHVIPGRSL
60 70 80 90 100
SELEAREADL GIVVGGDGTL LRTVQKSNAV LPPILGFSSD SLGYLLPHRV
110 120 130 140 150
DVAREVLEEV LRGNYSERDV ALGEFIAGER AGVFLNEVCV WSEPGKIVEF
160 170 180 190 200
EVLLNDESLY RVRGDGVIVA TPAGSTGHAF SYGGPVIIDT GQRALEVVFP
210 220 230 240 250
GALSPLIRPL IVHGGSIAVK VIAHPANLVV DGQVYSKLQE ASKVTVRPSS
260 270 280 290
KSLRFIYVEK YETPLPEKLA RRVLDRGLSY VVSSLFKQTP KP
Length:292
Mass (Da):31,982
Last modified:February 6, 2007 - v1
Checksum:iE251C2D1A4BF2159
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000505 Genomic DNA. Translation: ABL77929.1.
RefSeqiWP_011752194.1. NC_008698.1.
YP_919932.1. NC_008698.1.

Genome annotation databases

EnsemblBacteriaiABL77929; ABL77929; Tpen_0523.
GeneIDi4601340.
KEGGitpe:Tpen_0523.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000505 Genomic DNA. Translation: ABL77929.1.
RefSeqiWP_011752194.1. NC_008698.1.
YP_919932.1. NC_008698.1.

3D structure databases

ProteinModelPortaliA1RXJ9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi368408.Tpen_0523.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABL77929; ABL77929; Tpen_0523.
GeneIDi4601340.
KEGGitpe:Tpen_0523.

Phylogenomic databases

eggNOGiCOG0061.
KOiK00858.
OMAiGINWGEV.

Enzyme and pathway databases

BioCyciTPEN368408:GHSG-551-MONOMER.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase.
InterProiIPR017438. ATP-NAD_kinase_dom_1.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR016064. NAD/diacylglycerol_kinase.
IPR002504. NADK.
[Graphical view]
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Hrk 5Imported.

Entry informationi

Entry nameiA1RXJ9_THEPD
AccessioniPrimary (citable) accession number: A1RXJ9
Entry historyi
Integrated into UniProtKB/TrEMBL: February 6, 2007
Last sequence update: February 6, 2007
Last modified: July 22, 2015
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.