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A1RXJ9 (A1RXJ9_THEPD) Unreviewed, UniProtKB/TrEMBL

Last modified July 9, 2014. Version 48. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
NAD kinase HAMAP-Rule MF_00361

EC=2.7.1.23 HAMAP-Rule MF_00361
Alternative name(s):
ATP-dependent NAD kinase HAMAP-Rule MF_00361
Gene names
Name:nadK HAMAP-Rule MF_00361
Ordered Locus Names:Tpen_0523 EMBL ABL77929.1
OrganismThermofilum pendens (strain Hrk 5) [Reference proteome] [HAMAP] EMBL ABL77929.1
Taxonomic identifier368408 [NCBI]
Taxonomic lineageArchaeaCrenarchaeotaThermoproteiThermoprotealesThermofilaceaeThermofilum

Protein attributes

Sequence length292 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP By similarity. HAMAP-Rule MF_00361

Catalytic activity

ATP + NAD+ = ADP + NADP+. HAMAP-Rule MF_00361

Cofactor

Divalent metal ions By similarity. HAMAP-Rule MF_00361

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00361.

Sequence similarities

Belongs to the NAD kinase family. HAMAP-Rule MF_00361

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding67 – 682NAD By similarity HAMAP-Rule MF_00361
Nucleotide binding136 – 1372NAD By similarity HAMAP-Rule MF_00361
Nucleotide binding176 – 1816NAD By similarity HAMAP-Rule MF_00361

Sites

Active site671Proton acceptor By similarity HAMAP-Rule MF_00361
Binding site721NAD By similarity HAMAP-Rule MF_00361
Binding site1631NAD By similarity HAMAP-Rule MF_00361
Binding site1651NAD By similarity HAMAP-Rule MF_00361
Binding site1731NAD; via carbonyl oxygen By similarity HAMAP-Rule MF_00361
Binding site2331NAD By similarity HAMAP-Rule MF_00361

Sequences

Sequence LengthMass (Da)Tools
A1RXJ9 [UniParc].

Last modified February 6, 2007. Version 1.
Checksum: E251C2D1A4BF2159

FASTA29231,982
        10         20         30         40         50         60 
MSFRKVWMKA RANDPVVLEH ARLLYRYLTD RGLDVYVDPL LGHVIPGRSL SELEAREADL 

        70         80         90        100        110        120 
GIVVGGDGTL LRTVQKSNAV LPPILGFSSD SLGYLLPHRV DVAREVLEEV LRGNYSERDV 

       130        140        150        160        170        180 
ALGEFIAGER AGVFLNEVCV WSEPGKIVEF EVLLNDESLY RVRGDGVIVA TPAGSTGHAF 

       190        200        210        220        230        240 
SYGGPVIIDT GQRALEVVFP GALSPLIRPL IVHGGSIAVK VIAHPANLVV DGQVYSKLQE 

       250        260        270        280        290 
ASKVTVRPSS KSLRFIYVEK YETPLPEKLA RRVLDRGLSY VVSSLFKQTP KP 

« Hide

References

[1]"Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction."
Anderson I., Rodriguez J., Susanti D., Porat I., Reich C., Ulrich L.E., Elkins J.G., Mavromatis K., Lykidis A., Kim E., Thompson L.S., Nolan M., Land M., Copeland A., Lapidus A., Lucas S., Detter C., Zhulin I.B. expand/collapse author list , Olsen G.J., Whitman W., Mukhopadhyay B., Bristow J., Kyrpides N.
J. Bacteriol. 190:2957-2965(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Hrk 5.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000505 Genomic DNA. Translation: ABL77929.1.
RefSeqYP_919932.1. NC_008698.1.

3D structure databases

ProteinModelPortalA1RXJ9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING368408.Tpen_0523.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABL77929; ABL77929; Tpen_0523.
GeneID4601340.
KEGGtpe:Tpen_0523.

Phylogenomic databases

eggNOGCOG0061.
KOK00858.

Enzyme and pathway databases

BioCycTPEN368408:GHSG-551-MONOMER.

Family and domain databases

Gene3D2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPMF_00361. NAD_kinase.
InterProIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view]
PANTHERPTHR20275. PTHR20275. 1 hit.
PfamPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMSSF111331. SSF111331. 1 hit.
ProtoNetSearch...

Entry information

Entry nameA1RXJ9_THEPD
AccessionPrimary (citable) accession number: A1RXJ9
Entry history
Integrated into UniProtKB/TrEMBL: February 6, 2007
Last sequence update: February 6, 2007
Last modified: July 9, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)