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A1RXJ9

- A1RXJ9_THEPD

UniProt

A1RXJ9 - A1RXJ9_THEPD

Protein

NAD kinase

Gene

nadK

Organism
Thermofilum pendens (strain Hrk 5)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 49 (01 Oct 2014)
      Sequence version 1 (06 Feb 2007)
      Previous versions | rss
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    Functioni

    Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

    Catalytic activityi

    ATP + NAD+ = ADP + NADP+.UniRule annotation

    Cofactori

    Divalent metal ions.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei67 – 671Proton acceptorUniRule annotation
    Binding sitei72 – 721NADUniRule annotation
    Binding sitei163 – 1631NADUniRule annotation
    Binding sitei165 – 1651NADUniRule annotation
    Binding sitei173 – 1731NAD; via carbonyl oxygenUniRule annotation
    Binding sitei233 – 2331NADUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi67 – 682NADUniRule annotation
    Nucleotide bindingi136 – 1372NADUniRule annotation
    Nucleotide bindingi176 – 1816NADUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-HAMAP
    3. NAD+ kinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. NAD metabolic process Source: InterPro
    2. NADP biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    KinaseUniRule annotationImported, Transferase

    Keywords - Ligandi

    ATP-bindingUniRule annotation, NADUniRule annotation, NADPUniRule annotation, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciTPEN368408:GHSG-551-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
    Alternative name(s):
    ATP-dependent NAD kinaseUniRule annotation
    Gene namesi
    Name:nadKUniRule annotation
    Ordered Locus Names:Tpen_0523Imported
    OrganismiThermofilum pendens (strain Hrk 5)Imported
    Taxonomic identifieri368408 [NCBI]
    Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiThermoprotealesThermofilaceaeThermofilum
    ProteomesiUP000000641: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotation

    Interactioni

    Protein-protein interaction databases

    STRINGi368408.Tpen_0523.

    Structurei

    3D structure databases

    ProteinModelPortaliA1RXJ9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the NAD kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0061.
    KOiK00858.

    Family and domain databases

    Gene3Di2.60.200.30. 1 hit.
    3.40.50.10330. 1 hit.
    HAMAPiMF_00361. NAD_kinase.
    InterProiIPR017438. ATP-NAD_kinase_dom_1.
    IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
    IPR002504. PolyP/ATP_NADK.
    [Graphical view]
    PANTHERiPTHR20275. PTHR20275. 1 hit.
    PfamiPF01513. NAD_kinase. 1 hit.
    [Graphical view]
    SUPFAMiSSF111331. SSF111331. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A1RXJ9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSFRKVWMKA RANDPVVLEH ARLLYRYLTD RGLDVYVDPL LGHVIPGRSL    50
    SELEAREADL GIVVGGDGTL LRTVQKSNAV LPPILGFSSD SLGYLLPHRV 100
    DVAREVLEEV LRGNYSERDV ALGEFIAGER AGVFLNEVCV WSEPGKIVEF 150
    EVLLNDESLY RVRGDGVIVA TPAGSTGHAF SYGGPVIIDT GQRALEVVFP 200
    GALSPLIRPL IVHGGSIAVK VIAHPANLVV DGQVYSKLQE ASKVTVRPSS 250
    KSLRFIYVEK YETPLPEKLA RRVLDRGLSY VVSSLFKQTP KP 292
    Length:292
    Mass (Da):31,982
    Last modified:February 6, 2007 - v1
    Checksum:iE251C2D1A4BF2159
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000505 Genomic DNA. Translation: ABL77929.1.
    RefSeqiYP_919932.1. NC_008698.1.

    Genome annotation databases

    EnsemblBacteriaiABL77929; ABL77929; Tpen_0523.
    GeneIDi4601340.
    KEGGitpe:Tpen_0523.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000505 Genomic DNA. Translation: ABL77929.1 .
    RefSeqi YP_919932.1. NC_008698.1.

    3D structure databases

    ProteinModelPortali A1RXJ9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 368408.Tpen_0523.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABL77929 ; ABL77929 ; Tpen_0523 .
    GeneIDi 4601340.
    KEGGi tpe:Tpen_0523.

    Phylogenomic databases

    eggNOGi COG0061.
    KOi K00858.

    Enzyme and pathway databases

    BioCyci TPEN368408:GHSG-551-MONOMER.

    Family and domain databases

    Gene3Di 2.60.200.30. 1 hit.
    3.40.50.10330. 1 hit.
    HAMAPi MF_00361. NAD_kinase.
    InterProi IPR017438. ATP-NAD_kinase_dom_1.
    IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
    IPR002504. PolyP/ATP_NADK.
    [Graphical view ]
    PANTHERi PTHR20275. PTHR20275. 1 hit.
    Pfami PF01513. NAD_kinase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF111331. SSF111331. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Hrk 5Imported.

    Entry informationi

    Entry nameiA1RXJ9_THEPD
    AccessioniPrimary (citable) accession number: A1RXJ9
    Entry historyi
    Integrated into UniProtKB/TrEMBL: February 6, 2007
    Last sequence update: February 6, 2007
    Last modified: October 1, 2014
    This is version 49 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3