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A1RXA6

- DNLI1_THEPD

UniProt

A1RXA6 - DNLI1_THEPD

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Protein

DNA ligase 1

Gene
lig1, Tpen_0427
Organism
Thermofilum pendens (strain Hrk 5)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair By similarity.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

Cofactori

Divalent metal cations By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei221 – 2211ATP By similarity
Active sitei223 – 2231N6-AMP-lysine intermediate By similarity
Binding sitei228 – 2281ATP By similarity
Binding sitei243 – 2431ATP By similarity
Binding sitei273 – 2731ATP By similarity
Binding sitei312 – 3121ATP By similarity
Binding sitei385 – 3851ATP By similarity
Binding sitei391 – 3911ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
  4. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. DNA recombination Source: UniProtKB-HAMAP
  4. DNA repair Source: UniProtKB-HAMAP
  5. DNA replication Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Cell cycle, Cell division, DNA damage, DNA recombination, DNA repair, DNA replication

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciTPEN368408:GHSG-445-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligase 1 (EC:6.5.1.1)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP] 1
Gene namesi
Name:lig1
Ordered Locus Names:Tpen_0427
OrganismiThermofilum pendens (strain Hrk 5)
Taxonomic identifieri368408 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiThermoprotealesThermofilaceaeThermofilum
ProteomesiUP000000641: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 531531DNA ligase 1UniRule annotationPRO_0000365265Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi368408.Tpen_0427.

Structurei

3D structure databases

ProteinModelPortaliA1RXA6.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1793.
HOGENOMiHOG000036008.
KOiK10747.
OMAiKTENNIS.

Family and domain databases

Gene3Di1.10.3260.10. 2 hits.
2.40.50.140. 1 hit.
HAMAPiMF_00407. DNA_ligase.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1RXA6-1 [UniParc]FASTAAdd to Basket

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MALFRELVEA AEAAGRVSGR KEKVRILSEF LGRLSPEEAS IAARFLAGHV    50
FPEYDNRELG VGYSLVREAL KVLDQKPLFL VEPQPPAITE VYRLLERIAG 100
VSGEGSREKK LKLLEGLFSR LSRKEVEYLL RILFGEVRIG ASTGLLLEAI 150
SRLSGVPYGD VLHAYMVLSD VGDVAFKALE SPAALGKVDV SLFHPVKPML 200
ADMAYNVDEL FQEHGSPLHL EYKYDGLRVQ IHMGRGKVRV FSRRLSDITE 250
YVPDVVERAV EGLHVEEAVV DGEAVAVIGG APVPFQELLR RVRRKNERED 300
FLKSLPFELH LFDVIYLNGK SLVREPYSTR SRLLREIVVS EEILAKKTVA 350
YTRQEALEFY ESAVRSGNEG VMSKRHSSVY KPGIRGSDWL KLKSFDTIDC 400
VIIAAEWGHG RRSGWLSDYH LGVYDEESGR FLSVGKTFKG LSDAEFEEMT 450
KRLLQLKVRE EGYVVYVKPE IVVEVDYSEI QRSKRYPSGF ALRFARIRRI 500
RFDKSPYEVT TLRELRERYL RSIRAKRWSP Q 531
Length:531
Mass (Da):60,518
Last modified:February 6, 2007 - v1
Checksum:i2D5E122C73504389
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000505 Genomic DNA. Translation: ABL77836.1.
RefSeqiYP_919839.1. NC_008698.1.

Genome annotation databases

EnsemblBacteriaiABL77836; ABL77836; Tpen_0427.
GeneIDi4602106.
KEGGitpe:Tpen_0427.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000505 Genomic DNA. Translation: ABL77836.1 .
RefSeqi YP_919839.1. NC_008698.1.

3D structure databases

ProteinModelPortali A1RXA6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 368408.Tpen_0427.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABL77836 ; ABL77836 ; Tpen_0427 .
GeneIDi 4602106.
KEGGi tpe:Tpen_0427.

Phylogenomic databases

eggNOGi COG1793.
HOGENOMi HOG000036008.
KOi K10747.
OMAi KTENNIS.

Enzyme and pathway databases

BioCyci TPEN368408:GHSG-445-MONOMER.

Family and domain databases

Gene3Di 1.10.3260.10. 2 hits.
2.40.50.140. 1 hit.
HAMAPi MF_00407. DNA_ligase.
InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view ]
Pfami PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view ]
SUPFAMi SSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00574. dnl1. 1 hit.
PROSITEi PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Hrk 5.

Entry informationi

Entry nameiDNLI1_THEPD
AccessioniPrimary (citable) accession number: A1RXA6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: February 6, 2007
Last modified: May 14, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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