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Protein

DNA ligase 1

Gene

lig1

Organism
Thermofilum pendens (strain Hrk 5)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n)-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) + AMP + diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei221ATPUniRule annotation1
Active sitei223N6-AMP-lysine intermediateUniRule annotation1
Binding sitei228ATPUniRule annotation1
Binding sitei243ATPUniRule annotation1
Binding sitei273ATPUniRule annotation1
Binding sitei312ATPUniRule annotation1
Binding sitei385ATPUniRule annotation1
Binding sitei391ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Cell cycle, Cell division, DNA damage, DNA recombination, DNA repair, DNA replication

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligase 1UniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP] 1UniRule annotation
Gene namesi
Name:lig1UniRule annotation
Ordered Locus Names:Tpen_0427
OrganismiThermofilum pendens (strain Hrk 5)
Taxonomic identifieri368408 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiThermoprotealesThermofilaceaeThermofilum
Proteomesi
  • UP000000641 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003652651 – 531DNA ligase 1Add BLAST531

Interactioni

Protein-protein interaction databases

STRINGi368408.Tpen_0427.

Structurei

3D structure databases

ProteinModelPortaliA1RXA6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01347. Archaea.
COG1793. LUCA.
HOGENOMiHOG000036008.
KOiK10747.
OMAiPRITKWR.

Family and domain databases

Gene3Di1.10.3260.10. 2 hits.
HAMAPiMF_00407. DNA_ligase. 1 hit.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 2 hits.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1RXA6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALFRELVEA AEAAGRVSGR KEKVRILSEF LGRLSPEEAS IAARFLAGHV
60 70 80 90 100
FPEYDNRELG VGYSLVREAL KVLDQKPLFL VEPQPPAITE VYRLLERIAG
110 120 130 140 150
VSGEGSREKK LKLLEGLFSR LSRKEVEYLL RILFGEVRIG ASTGLLLEAI
160 170 180 190 200
SRLSGVPYGD VLHAYMVLSD VGDVAFKALE SPAALGKVDV SLFHPVKPML
210 220 230 240 250
ADMAYNVDEL FQEHGSPLHL EYKYDGLRVQ IHMGRGKVRV FSRRLSDITE
260 270 280 290 300
YVPDVVERAV EGLHVEEAVV DGEAVAVIGG APVPFQELLR RVRRKNERED
310 320 330 340 350
FLKSLPFELH LFDVIYLNGK SLVREPYSTR SRLLREIVVS EEILAKKTVA
360 370 380 390 400
YTRQEALEFY ESAVRSGNEG VMSKRHSSVY KPGIRGSDWL KLKSFDTIDC
410 420 430 440 450
VIIAAEWGHG RRSGWLSDYH LGVYDEESGR FLSVGKTFKG LSDAEFEEMT
460 470 480 490 500
KRLLQLKVRE EGYVVYVKPE IVVEVDYSEI QRSKRYPSGF ALRFARIRRI
510 520 530
RFDKSPYEVT TLRELRERYL RSIRAKRWSP Q
Length:531
Mass (Da):60,518
Last modified:February 6, 2007 - v1
Checksum:i2D5E122C73504389
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000505 Genomic DNA. Translation: ABL77836.1.

Genome annotation databases

EnsemblBacteriaiABL77836; ABL77836; Tpen_0427.
KEGGitpe:Tpen_0427.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000505 Genomic DNA. Translation: ABL77836.1.

3D structure databases

ProteinModelPortaliA1RXA6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi368408.Tpen_0427.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABL77836; ABL77836; Tpen_0427.
KEGGitpe:Tpen_0427.

Phylogenomic databases

eggNOGiarCOG01347. Archaea.
COG1793. LUCA.
HOGENOMiHOG000036008.
KOiK10747.
OMAiPRITKWR.

Family and domain databases

Gene3Di1.10.3260.10. 2 hits.
HAMAPiMF_00407. DNA_ligase. 1 hit.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 2 hits.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDNLI1_THEPD
AccessioniPrimary (citable) accession number: A1RXA6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: February 6, 2007
Last modified: November 30, 2016
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.