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Protein

DNA ligase 1

Gene

lig1

Organism
Thermofilum pendens (strain DSM 2475 / Hrk 5)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n)-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) + AMP + diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei221ATPUniRule annotation1
Active sitei223N6-AMP-lysine intermediateUniRule annotation1
Binding sitei228ATPUniRule annotation1
Binding sitei243ATPUniRule annotation1
Binding sitei273ATPUniRule annotation1
Binding sitei312ATPUniRule annotation1
Binding sitei385ATPUniRule annotation1
Binding sitei391ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processCell cycle, Cell division, DNA damage, DNA recombination, DNA repair, DNA replication
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligase 1UniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP] 1UniRule annotation
Gene namesi
Name:lig1UniRule annotation
Ordered Locus Names:Tpen_0427
OrganismiThermofilum pendens (strain DSM 2475 / Hrk 5)
Taxonomic identifieri368408 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiThermoprotealesThermofilaceaeThermofilum
Proteomesi
  • UP000000641 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003652651 – 531DNA ligase 1Add BLAST531

Interactioni

Protein-protein interaction databases

STRINGi368408.Tpen_0427

Structurei

3D structure databases

ProteinModelPortaliA1RXA6
SMRiA1RXA6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01347 Archaea
COG1793 LUCA
HOGENOMiHOG000036008
KOiK10747
OMAiGIMVKIL
OrthoDBiPOG093Z03L0

Family and domain databases

Gene3Di1.10.3260.10, 1 hit
HAMAPiMF_00407 DNA_ligase, 1 hit
InterProiView protein in InterPro
IPR022865 DNA_ligae_ATP-dep_bac/arc
IPR000977 DNA_ligase_ATP-dep
IPR012309 DNA_ligase_ATP-dep_C
IPR012310 DNA_ligase_ATP-dep_cent
IPR012308 DNA_ligase_ATP-dep_N
IPR036599 DNA_ligase_N_sf
IPR012340 NA-bd_OB-fold
PfamiView protein in Pfam
PF04679 DNA_ligase_A_C, 1 hit
PF01068 DNA_ligase_A_M, 1 hit
PF04675 DNA_ligase_A_N, 1 hit
SUPFAMiSSF117018 SSF117018, 1 hit
SSF50249 SSF50249, 1 hit
TIGRFAMsiTIGR00574 dnl1, 1 hit
PROSITEiView protein in PROSITE
PS50160 DNA_LIGASE_A3, 1 hit

Sequencei

Sequence statusi: Complete.

A1RXA6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALFRELVEA AEAAGRVSGR KEKVRILSEF LGRLSPEEAS IAARFLAGHV
60 70 80 90 100
FPEYDNRELG VGYSLVREAL KVLDQKPLFL VEPQPPAITE VYRLLERIAG
110 120 130 140 150
VSGEGSREKK LKLLEGLFSR LSRKEVEYLL RILFGEVRIG ASTGLLLEAI
160 170 180 190 200
SRLSGVPYGD VLHAYMVLSD VGDVAFKALE SPAALGKVDV SLFHPVKPML
210 220 230 240 250
ADMAYNVDEL FQEHGSPLHL EYKYDGLRVQ IHMGRGKVRV FSRRLSDITE
260 270 280 290 300
YVPDVVERAV EGLHVEEAVV DGEAVAVIGG APVPFQELLR RVRRKNERED
310 320 330 340 350
FLKSLPFELH LFDVIYLNGK SLVREPYSTR SRLLREIVVS EEILAKKTVA
360 370 380 390 400
YTRQEALEFY ESAVRSGNEG VMSKRHSSVY KPGIRGSDWL KLKSFDTIDC
410 420 430 440 450
VIIAAEWGHG RRSGWLSDYH LGVYDEESGR FLSVGKTFKG LSDAEFEEMT
460 470 480 490 500
KRLLQLKVRE EGYVVYVKPE IVVEVDYSEI QRSKRYPSGF ALRFARIRRI
510 520 530
RFDKSPYEVT TLRELRERYL RSIRAKRWSP Q
Length:531
Mass (Da):60,518
Last modified:February 6, 2007 - v1
Checksum:i2D5E122C73504389
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000505 Genomic DNA Translation: ABL77836.1

Genome annotation databases

EnsemblBacteriaiABL77836; ABL77836; Tpen_0427
KEGGitpe:Tpen_0427

Similar proteinsi

Entry informationi

Entry nameiDNLI1_THEPD
AccessioniPrimary (citable) accession number: A1RXA6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: February 6, 2007
Last modified: March 28, 2018
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health