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A1RXA6 (DNLI1_THEPD) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
DNA ligase 1

EC=6.5.1.1
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP] 1
Gene names
Name:lig1
Ordered Locus Names:Tpen_0427
OrganismThermofilum pendens (strain Hrk 5) [Reference proteome] [HAMAP]
Taxonomic identifier368408 [NCBI]
Taxonomic lineageArchaeaCrenarchaeotaThermoproteiThermoprotealesThermofilaceaeThermofilum

Protein attributes

Sequence length531 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair By similarity. HAMAP-Rule MF_00407

Catalytic activity

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m). HAMAP-Rule MF_00407

Cofactor

Divalent metal cations By similarity. HAMAP-Rule MF_00407

Sequence similarities

Belongs to the ATP-dependent DNA ligase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 531531DNA ligase 1 HAMAP-Rule MF_00407
PRO_0000365265

Sites

Active site2231N6-AMP-lysine intermediate By similarity
Binding site2211ATP By similarity
Binding site2281ATP By similarity
Binding site2431ATP By similarity
Binding site2731ATP By similarity
Binding site3121ATP By similarity
Binding site3851ATP By similarity
Binding site3911ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
A1RXA6 [UniParc].

Last modified February 6, 2007. Version 1.
Checksum: 2D5E122C73504389

FASTA53160,518
        10         20         30         40         50         60 
MALFRELVEA AEAAGRVSGR KEKVRILSEF LGRLSPEEAS IAARFLAGHV FPEYDNRELG 

        70         80         90        100        110        120 
VGYSLVREAL KVLDQKPLFL VEPQPPAITE VYRLLERIAG VSGEGSREKK LKLLEGLFSR 

       130        140        150        160        170        180 
LSRKEVEYLL RILFGEVRIG ASTGLLLEAI SRLSGVPYGD VLHAYMVLSD VGDVAFKALE 

       190        200        210        220        230        240 
SPAALGKVDV SLFHPVKPML ADMAYNVDEL FQEHGSPLHL EYKYDGLRVQ IHMGRGKVRV 

       250        260        270        280        290        300 
FSRRLSDITE YVPDVVERAV EGLHVEEAVV DGEAVAVIGG APVPFQELLR RVRRKNERED 

       310        320        330        340        350        360 
FLKSLPFELH LFDVIYLNGK SLVREPYSTR SRLLREIVVS EEILAKKTVA YTRQEALEFY 

       370        380        390        400        410        420 
ESAVRSGNEG VMSKRHSSVY KPGIRGSDWL KLKSFDTIDC VIIAAEWGHG RRSGWLSDYH 

       430        440        450        460        470        480 
LGVYDEESGR FLSVGKTFKG LSDAEFEEMT KRLLQLKVRE EGYVVYVKPE IVVEVDYSEI 

       490        500        510        520        530 
QRSKRYPSGF ALRFARIRRI RFDKSPYEVT TLRELRERYL RSIRAKRWSP Q 

« Hide

References

[1]"Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction."
Anderson I., Rodriguez J., Susanti D., Porat I., Reich C., Ulrich L.E., Elkins J.G., Mavromatis K., Lykidis A., Kim E., Thompson L.S., Nolan M., Land M., Copeland A., Lapidus A., Lucas S., Detter C., Zhulin I.B. expand/collapse author list , Olsen G.J., Whitman W., Mukhopadhyay B., Bristow J., Kyrpides N.
J. Bacteriol. 190:2957-2965(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Hrk 5.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000505 Genomic DNA. Translation: ABL77836.1.
RefSeqYP_919839.1. NC_008698.1.

3D structure databases

ProteinModelPortalA1RXA6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING368408.Tpen_0427.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABL77836; ABL77836; Tpen_0427.
GeneID4602106.
KEGGtpe:Tpen_0427.

Phylogenomic databases

eggNOGCOG1793.
HOGENOMHOG000036008.
KOK10747.
OMAKTENNIS.

Enzyme and pathway databases

BioCycTPEN368408:GHSG-445-MONOMER.

Family and domain databases

Gene3D1.10.3260.10. 2 hits.
2.40.50.140. 1 hit.
HAMAPMF_00407. DNA_ligase.
InterProIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsTIGR00574. dnl1. 1 hit.
PROSITEPS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDNLI1_THEPD
AccessionPrimary (citable) accession number: A1RXA6
Entry history
Integrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: February 6, 2007
Last modified: May 14, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families