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Protein

Proteasome subunit beta 2

Gene

psmB2

Organism
Thermofilum pendens (strain DSM 2475 / Hrk 5)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.UniRule annotation

Catalytic activityi

Cleavage of peptide bonds with very broad specificity.UniRule annotation

Enzyme regulationi

The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei7NucleophileUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Threonine protease

Names & Taxonomyi

Protein namesi
Recommended name:
Proteasome subunit beta 2UniRule annotation (EC:3.4.25.1UniRule annotation)
Alternative name(s):
20S proteasome beta subunit 2UniRule annotation
Proteasome core protein PsmB 2UniRule annotation
Gene namesi
Name:psmB2UniRule annotation
Ordered Locus Names:Tpen_0392
OrganismiThermofilum pendens (strain DSM 2475 / Hrk 5)
Taxonomic identifieri368408 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiThermoprotealesThermofilaceaeThermofilum
Proteomesi
  • UP000000641 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm, Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PropeptideiPRO_00003974781 – 6Removed in mature form; by autocatalysisUniRule annotation6
ChainiPRO_00003974797 – 204Proteasome subunit beta 2Add BLAST198

Keywords - PTMi

Autocatalytic cleavage, Zymogen

Proteomic databases

PRIDEiA1RX71

Interactioni

Subunit structurei

The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.UniRule annotation

Protein-protein interaction databases

STRINGi368408.Tpen_0392

Structurei

3D structure databases

ProteinModelPortaliA1RX71
SMRiA1RX71
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase T1B family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00970 Archaea
COG0638 LUCA
HOGENOMiHOG000091083
KOiK03433
OMAiQTLFRYR
OrthoDBiPOG093Z0CM8

Family and domain databases

Gene3Di3.60.20.10, 1 hit
HAMAPiMF_02113_A Proteasome_B_A, 1 hit
InterProiView protein in InterPro
IPR029055 Ntn_hydrolases_N
IPR019983 Pept_T1A_Psome_bsu_arc
IPR000243 Pept_T1A_subB
IPR016050 Proteasome_bsu_CS
IPR001353 Proteasome_sua/b
IPR023333 Proteasome_suB-type
PANTHERiPTHR11599:SF108 PTHR11599:SF108, 1 hit
PfamiView protein in Pfam
PF00227 Proteasome, 1 hit
PRINTSiPR00141 PROTEASOME
SUPFAMiSSF56235 SSF56235, 1 hit
TIGRFAMsiTIGR03634 arc_protsome_B, 1 hit
PROSITEiView protein in PROSITE
PS00854 PROTEASOME_BETA_1, 1 hit
PS51476 PROTEASOME_BETA_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A1RX71-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEVLPGTTVG IRVSDGVVLA AEKRVSYGLY LMSKSGKKVY RILDKMGMAS
60 70 80 90 100
AGLMADMQTL ARIVEAEMRL YELDSNISPK VWTVAKLLSY ILYERRLFPY
110 120 130 140 150
YAEIVVGGLD EEGSHLYSLD PIGAIIEDDY VALGSGTQLA ISIVESNYKK
160 170 180 190 200
DMSLDEALSL ALKSVYAAMK RDAASGDGVD VLVIGKSGTL EKTYPLSELQ

SVAV
Length:204
Mass (Da):22,161
Last modified:February 6, 2007 - v1
Checksum:iAF45C4D4B1508252
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000505 Genomic DNA Translation: ABL77801.1
RefSeqiWP_011752066.1, NC_008698.1

Genome annotation databases

EnsemblBacteriaiABL77801; ABL77801; Tpen_0392
GeneIDi4600527
KEGGitpe:Tpen_0392

Similar proteinsi

Entry informationi

Entry nameiPSB2_THEPD
AccessioniPrimary (citable) accession number: A1RX71
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 10, 2010
Last sequence update: February 6, 2007
Last modified: May 23, 2018
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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