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A1RWC3

- AMPPA_THEPD

UniProt

A1RWC3 - AMPPA_THEPD

Protein

AMP phosphorylase

Gene

Tpen_0093

Organism
Thermofilum pendens (strain Hrk 5)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 54 (01 Oct 2014)
      Sequence version 2 (15 Jan 2008)
      Previous versions | rss
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    Functioni

    Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO.UniRule annotation

    Catalytic activityi

    AMP + phosphate = adenine + alpha-D-ribose 1,5-bisphosphate.UniRule annotation
    CMP + phosphate = cytosine + alpha-D-ribose 1,5-bisphosphate.UniRule annotation
    UMP + phosphate = uracil + alpha-D-ribose 1,5-bisphosphate.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei168 – 1681AMP; via amide nitrogenUniRule annotation
    Binding sitei203 – 2031AMP; via amide nitrogenUniRule annotation
    Active sitei256 – 2561Proton donorUniRule annotation
    Binding sitei262 – 2621AMPUniRule annotation
    Binding sitei286 – 2861AMPUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi194 – 1996AMPUniRule annotation

    GO - Molecular functioni

    1. AMP binding Source: UniProtKB-HAMAP
    2. phosphorylase activity Source: InterPro
    3. thymidine phosphorylase activity Source: InterPro

    GO - Biological processi

    1. AMP catabolic process Source: UniProtKB-HAMAP
    2. pyrimidine deoxyribonucleoside metabolic process Source: InterPro
    3. pyrimidine nucleobase metabolic process Source: InterPro

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Enzyme and pathway databases

    BioCyciTPEN368408:GHSG-95-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    AMP phosphorylaseUniRule annotation (EC:2.4.2.57UniRule annotation)
    Short name:
    AMPpaseUniRule annotation
    Alternative name(s):
    Nucleoside monophosphate phosphorylaseUniRule annotation
    Short name:
    NMP phosphorylaseUniRule annotation
    Gene namesi
    Ordered Locus Names:Tpen_0093
    OrganismiThermofilum pendens (strain Hrk 5)
    Taxonomic identifieri368408 [NCBI]
    Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiThermoprotealesThermofilaceaeThermofilum
    ProteomesiUP000000641: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 511511AMP phosphorylasePRO_0000314732Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi368408.Tpen_0093.

    Structurei

    3D structure databases

    ProteinModelPortaliA1RWC3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0213.
    HOGENOMiHOG000252767.
    KOiK00758.

    Family and domain databases

    Gene3Di3.40.1030.10. 1 hit.
    3.90.1170.30. 1 hit.
    HAMAPiMF_02132. AMP_phosphorylase.
    InterProiIPR017713. AMP_phosphorylase.
    IPR000312. Glycosyl_Trfase_fam3.
    IPR017459. Glycosyl_Trfase_fam3_N_dom.
    IPR013102. PYNP_C.
    IPR000053. Pyrmidine_PPase.
    IPR017872. Pyrmidine_PPase_CS.
    IPR013466. Thymidine/AMP_Pase.
    [Graphical view]
    PANTHERiPTHR10515. PTHR10515. 1 hit.
    PfamiPF02885. Glycos_trans_3N. 1 hit.
    PF00591. Glycos_transf_3. 1 hit.
    PF07831. PYNP_C. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000478. TP_PyNP. 1 hit.
    SMARTiSM00941. PYNP_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF47648. SSF47648. 1 hit.
    SSF52418. SSF52418. 1 hit.
    SSF54680. SSF54680. 1 hit.
    TIGRFAMsiTIGR03327. AMP_phos. 1 hit.
    TIGR02645. ARCH_P_rylase. 1 hit.
    PROSITEiPS00647. THYMID_PHOSPHORYLASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A1RWC3-1 [UniParc]FASTAAdd to Basket

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    MKLKTRILPF ESAHYTVVLD QSVAKKLDVR PSDRVLVRFN GKTVVAIANI    50
    AKEFSHEHVG VYVNIAKALG ISDGDEVEVE ATSPPASLQA IRKKLQGLSL 100
    ESDEIYQVVK DIVDGKLSEL ELAAFVTAVH FQGMTPSEIY SFTLSMVETG 150
    QRLRLKRKPI LDKHSLGGVP GDKTSLLVVP IIASLGFTIP KTSSRAITSA 200
    AGTADRMEVL APVNLSIDEI ERIVEKTNAC LVWGGALNLA PADDIIIRVE 250
    YPLGIDPFYI PSILAKKLAV GSTHVVLDVP TGRGTKVKTL EEAKRISQSF 300
    FEIARMFGMN LQAVATYAEE PIGHAIGPAL EAREALIALR ELRPGDLVDK 350
    AASLAGTLLE MVGVENGYET AMEALRTGKA EKKLREIIEA QGGDPDVTPE 400
    EIPLGDKTYT LYSEEDGFVY YIDNSLLANI GKIAGAPIDK GAGVYIHVKL 450
    GEKVRKGDPL LTVYSSSSAK LQAVERILED SKPVLVGRTA GRRMLLERIQ 500
    YQPPRQLVLE R 511
    Length:511
    Mass (Da):55,569
    Last modified:January 15, 2008 - v2
    Checksum:iC655AF7EA9714244
    GO

    Sequence cautioni

    The sequence ABL77503.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000505 Genomic DNA. Translation: ABL77503.1. Different initiation.
    RefSeqiYP_919506.1. NC_008698.1.

    Genome annotation databases

    EnsemblBacteriaiABL77503; ABL77503; Tpen_0093.
    GeneIDi4601385.
    KEGGitpe:Tpen_0093.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000505 Genomic DNA. Translation: ABL77503.1 . Different initiation.
    RefSeqi YP_919506.1. NC_008698.1.

    3D structure databases

    ProteinModelPortali A1RWC3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 368408.Tpen_0093.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABL77503 ; ABL77503 ; Tpen_0093 .
    GeneIDi 4601385.
    KEGGi tpe:Tpen_0093.

    Phylogenomic databases

    eggNOGi COG0213.
    HOGENOMi HOG000252767.
    KOi K00758.

    Enzyme and pathway databases

    BioCyci TPEN368408:GHSG-95-MONOMER.

    Family and domain databases

    Gene3Di 3.40.1030.10. 1 hit.
    3.90.1170.30. 1 hit.
    HAMAPi MF_02132. AMP_phosphorylase.
    InterProi IPR017713. AMP_phosphorylase.
    IPR000312. Glycosyl_Trfase_fam3.
    IPR017459. Glycosyl_Trfase_fam3_N_dom.
    IPR013102. PYNP_C.
    IPR000053. Pyrmidine_PPase.
    IPR017872. Pyrmidine_PPase_CS.
    IPR013466. Thymidine/AMP_Pase.
    [Graphical view ]
    PANTHERi PTHR10515. PTHR10515. 1 hit.
    Pfami PF02885. Glycos_trans_3N. 1 hit.
    PF00591. Glycos_transf_3. 1 hit.
    PF07831. PYNP_C. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000478. TP_PyNP. 1 hit.
    SMARTi SM00941. PYNP_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47648. SSF47648. 1 hit.
    SSF52418. SSF52418. 1 hit.
    SSF54680. SSF54680. 1 hit.
    TIGRFAMsi TIGR03327. AMP_phos. 1 hit.
    TIGR02645. ARCH_P_rylase. 1 hit.
    PROSITEi PS00647. THYMID_PHOSPHORYLASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Hrk 5.

    Entry informationi

    Entry nameiAMPPA_THEPD
    AccessioniPrimary (citable) accession number: A1RWC3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: January 15, 2008
    Last modified: October 1, 2014
    This is version 54 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3