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A1RWC3

- AMPPA_THEPD

UniProt

A1RWC3 - AMPPA_THEPD

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Protein
AMP phosphorylase
Gene
Tpen_0093
Organism
Thermofilum pendens (strain Hrk 5)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO By similarity.UniRule annotation

Catalytic activityi

AMP + phosphate = adenine + alpha-D-ribose 1,5-bisphosphate.UniRule annotation
CMP + phosphate = cytosine + alpha-D-ribose 1,5-bisphosphate.UniRule annotation
UMP + phosphate = uracil + alpha-D-ribose 1,5-bisphosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei168 – 1681AMP; via amide nitrogen By similarity
Binding sitei203 – 2031AMP; via amide nitrogen By similarity
Active sitei256 – 2561Proton donor By similarity
Binding sitei262 – 2621AMP By similarity
Binding sitei286 – 2861AMP By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi194 – 1996AMP By similarity

GO - Molecular functioni

  1. AMP binding Source: UniProtKB-HAMAP
  2. phosphorylase activity Source: InterPro
  3. thymidine phosphorylase activity Source: InterPro

GO - Biological processi

  1. AMP catabolic process Source: UniProtKB-HAMAP
  2. pyrimidine deoxyribonucleoside metabolic process Source: InterPro
  3. pyrimidine nucleobase metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

BioCyciTPEN368408:GHSG-95-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
AMP phosphorylase (EC:2.4.2.57)
Short name:
AMPpase
Alternative name(s):
Nucleoside monophosphate phosphorylase
Short name:
NMP phosphorylase
Gene namesi
Ordered Locus Names:Tpen_0093
OrganismiThermofilum pendens (strain Hrk 5)
Taxonomic identifieri368408 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiThermoprotealesThermofilaceaeThermofilum
ProteomesiUP000000641: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 511511AMP phosphorylaseUniRule annotation
PRO_0000314732Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi368408.Tpen_0093.

Structurei

3D structure databases

ProteinModelPortaliA1RWC3.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0213.
HOGENOMiHOG000252767.
KOiK00758.

Family and domain databases

Gene3Di3.40.1030.10. 1 hit.
3.90.1170.30. 1 hit.
HAMAPiMF_02132. AMP_phosphorylase.
InterProiIPR017713. AMP_phosphorylase.
IPR000312. Glycosyl_Trfase_fam3.
IPR017459. Glycosyl_Trfase_fam3_N_dom.
IPR013102. PYNP_C.
IPR000053. Pyrmidine_PPase.
IPR017872. Pyrmidine_PPase_CS.
IPR013466. Thymidine/AMP_Pase.
[Graphical view]
PANTHERiPTHR10515. PTHR10515. 1 hit.
PfamiPF02885. Glycos_trans_3N. 1 hit.
PF00591. Glycos_transf_3. 1 hit.
PF07831. PYNP_C. 1 hit.
[Graphical view]
PIRSFiPIRSF000478. TP_PyNP. 1 hit.
SMARTiSM00941. PYNP_C. 1 hit.
[Graphical view]
SUPFAMiSSF47648. SSF47648. 1 hit.
SSF52418. SSF52418. 1 hit.
SSF54680. SSF54680. 1 hit.
TIGRFAMsiTIGR03327. AMP_phos. 1 hit.
TIGR02645. ARCH_P_rylase. 1 hit.
PROSITEiPS00647. THYMID_PHOSPHORYLASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1RWC3-1 [UniParc]FASTAAdd to Basket

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MKLKTRILPF ESAHYTVVLD QSVAKKLDVR PSDRVLVRFN GKTVVAIANI    50
AKEFSHEHVG VYVNIAKALG ISDGDEVEVE ATSPPASLQA IRKKLQGLSL 100
ESDEIYQVVK DIVDGKLSEL ELAAFVTAVH FQGMTPSEIY SFTLSMVETG 150
QRLRLKRKPI LDKHSLGGVP GDKTSLLVVP IIASLGFTIP KTSSRAITSA 200
AGTADRMEVL APVNLSIDEI ERIVEKTNAC LVWGGALNLA PADDIIIRVE 250
YPLGIDPFYI PSILAKKLAV GSTHVVLDVP TGRGTKVKTL EEAKRISQSF 300
FEIARMFGMN LQAVATYAEE PIGHAIGPAL EAREALIALR ELRPGDLVDK 350
AASLAGTLLE MVGVENGYET AMEALRTGKA EKKLREIIEA QGGDPDVTPE 400
EIPLGDKTYT LYSEEDGFVY YIDNSLLANI GKIAGAPIDK GAGVYIHVKL 450
GEKVRKGDPL LTVYSSSSAK LQAVERILED SKPVLVGRTA GRRMLLERIQ 500
YQPPRQLVLE R 511
Length:511
Mass (Da):55,569
Last modified:January 15, 2008 - v2
Checksum:iC655AF7EA9714244
GO

Sequence cautioni

The sequence ABL77503.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000505 Genomic DNA. Translation: ABL77503.1. Different initiation.
RefSeqiYP_919506.1. NC_008698.1.

Genome annotation databases

EnsemblBacteriaiABL77503; ABL77503; Tpen_0093.
GeneIDi4601385.
KEGGitpe:Tpen_0093.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000505 Genomic DNA. Translation: ABL77503.1 . Different initiation.
RefSeqi YP_919506.1. NC_008698.1.

3D structure databases

ProteinModelPortali A1RWC3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 368408.Tpen_0093.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABL77503 ; ABL77503 ; Tpen_0093 .
GeneIDi 4601385.
KEGGi tpe:Tpen_0093.

Phylogenomic databases

eggNOGi COG0213.
HOGENOMi HOG000252767.
KOi K00758.

Enzyme and pathway databases

BioCyci TPEN368408:GHSG-95-MONOMER.

Family and domain databases

Gene3Di 3.40.1030.10. 1 hit.
3.90.1170.30. 1 hit.
HAMAPi MF_02132. AMP_phosphorylase.
InterProi IPR017713. AMP_phosphorylase.
IPR000312. Glycosyl_Trfase_fam3.
IPR017459. Glycosyl_Trfase_fam3_N_dom.
IPR013102. PYNP_C.
IPR000053. Pyrmidine_PPase.
IPR017872. Pyrmidine_PPase_CS.
IPR013466. Thymidine/AMP_Pase.
[Graphical view ]
PANTHERi PTHR10515. PTHR10515. 1 hit.
Pfami PF02885. Glycos_trans_3N. 1 hit.
PF00591. Glycos_transf_3. 1 hit.
PF07831. PYNP_C. 1 hit.
[Graphical view ]
PIRSFi PIRSF000478. TP_PyNP. 1 hit.
SMARTi SM00941. PYNP_C. 1 hit.
[Graphical view ]
SUPFAMi SSF47648. SSF47648. 1 hit.
SSF52418. SSF52418. 1 hit.
SSF54680. SSF54680. 1 hit.
TIGRFAMsi TIGR03327. AMP_phos. 1 hit.
TIGR02645. ARCH_P_rylase. 1 hit.
PROSITEi PS00647. THYMID_PHOSPHORYLASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Hrk 5.

Entry informationi

Entry nameiAMPPA_THEPD
AccessioniPrimary (citable) accession number: A1RWC3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: May 14, 2014
This is version 53 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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