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Protein

AMP phosphorylase

Gene

Tpen_0093

Organism
Thermofilum pendens (strain Hrk 5)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO.UniRule annotation

Catalytic activityi

AMP + phosphate = adenine + alpha-D-ribose 1,5-bisphosphate.UniRule annotation
CMP + phosphate = cytosine + alpha-D-ribose 1,5-bisphosphate.UniRule annotation
UMP + phosphate = uracil + alpha-D-ribose 1,5-bisphosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei168AMP; via amide nitrogenUniRule annotation1
Binding sitei203AMP; via amide nitrogenUniRule annotation1
Active sitei256Proton donorUniRule annotation1
Binding sitei262AMPUniRule annotation1
Binding sitei286AMPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi194 – 199AMPUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
AMP phosphorylaseUniRule annotation (EC:2.4.2.57UniRule annotation)
Short name:
AMPpaseUniRule annotation
Alternative name(s):
Nucleoside monophosphate phosphorylaseUniRule annotation
Short name:
NMP phosphorylaseUniRule annotation
Gene namesi
Ordered Locus Names:Tpen_0093
OrganismiThermofilum pendens (strain Hrk 5)
Taxonomic identifieri368408 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiThermoprotealesThermofilaceaeThermofilum
Proteomesi
  • UP000000641 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003147321 – 511AMP phosphorylaseAdd BLAST511

Proteomic databases

PRIDEiA1RWC3.

Interactioni

Protein-protein interaction databases

STRINGi368408.Tpen_0093.

Structurei

3D structure databases

ProteinModelPortaliA1RWC3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiarCOG02013. Archaea.
COG0213. LUCA.
HOGENOMiHOG000252767.
KOiK18931.

Family and domain databases

Gene3Di3.40.1030.10. 1 hit.
3.90.1170.30. 1 hit.
HAMAPiMF_02132. AMP_phosphorylase. 1 hit.
InterProiIPR017713. AMP_phosphorylase.
IPR000312. Glycosyl_Trfase_fam3.
IPR017459. Glycosyl_Trfase_fam3_N_dom.
IPR013102. PYNP_C.
IPR017872. Pyrmidine_PPase_CS.
IPR013466. Thymidine/AMP_Pase.
IPR000053. Thymidine/pyrmidine_PPase.
[Graphical view]
PANTHERiPTHR10515. PTHR10515. 1 hit.
PfamiPF02885. Glycos_trans_3N. 1 hit.
PF00591. Glycos_transf_3. 1 hit.
PF07831. PYNP_C. 1 hit.
[Graphical view]
SMARTiSM00941. PYNP_C. 1 hit.
[Graphical view]
SUPFAMiSSF47648. SSF47648. 1 hit.
SSF52418. SSF52418. 1 hit.
SSF54680. SSF54680. 1 hit.
TIGRFAMsiTIGR03327. AMP_phos. 1 hit.
TIGR02645. ARCH_P_rylase. 1 hit.
PROSITEiPS00647. THYMID_PHOSPHORYLASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1RWC3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLKTRILPF ESAHYTVVLD QSVAKKLDVR PSDRVLVRFN GKTVVAIANI
60 70 80 90 100
AKEFSHEHVG VYVNIAKALG ISDGDEVEVE ATSPPASLQA IRKKLQGLSL
110 120 130 140 150
ESDEIYQVVK DIVDGKLSEL ELAAFVTAVH FQGMTPSEIY SFTLSMVETG
160 170 180 190 200
QRLRLKRKPI LDKHSLGGVP GDKTSLLVVP IIASLGFTIP KTSSRAITSA
210 220 230 240 250
AGTADRMEVL APVNLSIDEI ERIVEKTNAC LVWGGALNLA PADDIIIRVE
260 270 280 290 300
YPLGIDPFYI PSILAKKLAV GSTHVVLDVP TGRGTKVKTL EEAKRISQSF
310 320 330 340 350
FEIARMFGMN LQAVATYAEE PIGHAIGPAL EAREALIALR ELRPGDLVDK
360 370 380 390 400
AASLAGTLLE MVGVENGYET AMEALRTGKA EKKLREIIEA QGGDPDVTPE
410 420 430 440 450
EIPLGDKTYT LYSEEDGFVY YIDNSLLANI GKIAGAPIDK GAGVYIHVKL
460 470 480 490 500
GEKVRKGDPL LTVYSSSSAK LQAVERILED SKPVLVGRTA GRRMLLERIQ
510
YQPPRQLVLE R
Length:511
Mass (Da):55,569
Last modified:January 15, 2008 - v2
Checksum:iC655AF7EA9714244
GO

Sequence cautioni

The sequence ABL77503 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000505 Genomic DNA. Translation: ABL77503.1. Different initiation.
RefSeqiWP_011751768.1. NC_008698.1.

Genome annotation databases

EnsemblBacteriaiABL77503; ABL77503; Tpen_0093.
GeneIDi4601385.
KEGGitpe:Tpen_0093.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000505 Genomic DNA. Translation: ABL77503.1. Different initiation.
RefSeqiWP_011751768.1. NC_008698.1.

3D structure databases

ProteinModelPortaliA1RWC3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi368408.Tpen_0093.

Proteomic databases

PRIDEiA1RWC3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABL77503; ABL77503; Tpen_0093.
GeneIDi4601385.
KEGGitpe:Tpen_0093.

Phylogenomic databases

eggNOGiarCOG02013. Archaea.
COG0213. LUCA.
HOGENOMiHOG000252767.
KOiK18931.

Family and domain databases

Gene3Di3.40.1030.10. 1 hit.
3.90.1170.30. 1 hit.
HAMAPiMF_02132. AMP_phosphorylase. 1 hit.
InterProiIPR017713. AMP_phosphorylase.
IPR000312. Glycosyl_Trfase_fam3.
IPR017459. Glycosyl_Trfase_fam3_N_dom.
IPR013102. PYNP_C.
IPR017872. Pyrmidine_PPase_CS.
IPR013466. Thymidine/AMP_Pase.
IPR000053. Thymidine/pyrmidine_PPase.
[Graphical view]
PANTHERiPTHR10515. PTHR10515. 1 hit.
PfamiPF02885. Glycos_trans_3N. 1 hit.
PF00591. Glycos_transf_3. 1 hit.
PF07831. PYNP_C. 1 hit.
[Graphical view]
SMARTiSM00941. PYNP_C. 1 hit.
[Graphical view]
SUPFAMiSSF47648. SSF47648. 1 hit.
SSF52418. SSF52418. 1 hit.
SSF54680. SSF54680. 1 hit.
TIGRFAMsiTIGR03327. AMP_phos. 1 hit.
TIGR02645. ARCH_P_rylase. 1 hit.
PROSITEiPS00647. THYMID_PHOSPHORYLASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAMPPA_THEPD
AccessioniPrimary (citable) accession number: A1RWC3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: November 30, 2016
This is version 68 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.