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A1RVE1 (AROB_PYRIL) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 35. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-dehydroquinate synthase
EC=4.2.3.4
Gene names
Name:aroB
Ordered Locus Names:Pisl_1774
OrganismPyrobaculum islandicum (strain DSM 4184 / JCM 9189) [Complete proteome] [HAMAP]
Taxonomic identifier384616 [NCBI]
Taxonomic lineageArchaea › Crenarchaeota › Thermoprotei › Thermoproteales › Thermoproteaceae › Pyrobaculum

Protein attributes

Sequence length343 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate = 3-dehydroquinate + phosphate. HAMAP MF_00110

Cofactor

Divalent metal cations By similarity. HAMAP MF_00110

NAD By similarity. HAMAP MF_00110

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7. HAMAP MF_00110

Subunit structure

Monomer By similarity. HAMAP MF_00110

Subcellular location

Cytoplasm By similarity HAMAP MF_00110.

Sequence similarities

Belongs to the dehydroquinate synthase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
   Cellular componentCytoplasm
   LigandNAD
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processaromatic amino acid family biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular function3-dehydroquinate synthase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3433433-dehydroquinate synthase HAMAP MF_00110
PRO_1000117497

Sequences

Sequence LengthMass (Da)Tools
A1RVE1 [UniParc].

Last modified February 6, 2007. Version 1.
Checksum: BA90EEBF19FF435E

FASTA34337,450
        10         20         30         40         50         60 
MRRFFYRHTR GVTEVVVGRG LPYGEYIERP VVLAEEGLRP PIPGAPTLVL RGGEEVKSLE 

        70         80         90        100        110        120 
VLTKVYSFLK EVGADRSTTL VAVGGGALLD LATFAAGTYM RGIRLVHIPT TLLAMVDAAL 

       130        140        150        160        170        180 
GGKGAVDWGP VKNLVGVFYQ PAAILCDLSW LETLPERVYR SAFAEVVKYG LALDGDFYSW 

       190        200        210        220        230        240 
VRENAKALLA RDWGALEYAV YRSLQLKAGV VEVDEFEERG IRQVLNVGHT VGHAVERVLG 

       250        260        270        280        290        300 
LLHGEAVAVG IVAELRLSSE LGYLRESHVA EAAEVLSSLG LPTSVKATEQ QLAEAAALVK 

       310        320        330        340 
FDKKRRGGHI YIPLVVRPGR WILEKIAVEE VEKAVRYVLH QGG

« Hide

References

[1]"Complete sequence of Pyrobaculum islandicum DSM 4184."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Meincke L., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J., Larimer F., Land M. expand/collapse author list , Hauser L., Kyrpides N., Mikhailova N., Lowe T., Richardson P.
Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 4184 / JCM 9189.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000504 Genomic DNA. Translation: ABL88923.1.
RefSeqYP_931266.1. NC_008701.1.

3D structure databases

ProteinModelPortalA1RVE1.
ModBaseSearch...

Protein-protein interaction databases

STRINGA1RVE1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4617865.
GenomeReviewsGene locus Pisl_1774 in contig CP000504_GR.
KEGGpis:Pisl_1774.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGarNOG06908.
HOGENOMHBG632303.
OMAMADEHEQ.
PhylomeDBA1RVE1.
ProtClustDBPRK00002.

Enzyme and pathway databases

BioCycPISL384616:PISL_1774-MONOMER.

Family and domain databases

HAMAPMF_00110. DHQ_synthase.
[Tree]
InterProIPR016037. DHQ_synth_AroB.
[Graphical view]
KOK01735.
PANTHERPTHR21090:SF1. DHQ_synth_AroB. 1 hit.
PIRSFPIRSF001455. DHQ_synth. 1 hit.
ProtoNetSearch...

Entry information

Entry nameAROB_PYRIL
AccessionPrimary (citable) accession number: A1RVE1
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: February 6, 2007
Last modified: November 16, 2011
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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