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Protein

tRNA pseudouridine synthase A

Gene

truA

Organism
Pyrobaculum islandicum (strain DSM 4184 / JCM 9189 / GEO3)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.UniRule annotation

Catalytic activityi

tRNA uridine(38-40) = tRNA pseudouridine(38-40).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei43NucleophileUniRule annotation1
Binding sitei94SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processtRNA processing

Enzyme and pathway databases

BioCyciPISL384616:G1G7P-1406-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA pseudouridine synthase AUniRule annotation (EC:5.4.99.12UniRule annotation)
Alternative name(s):
tRNA pseudouridine(38-40) synthaseUniRule annotation
tRNA pseudouridylate synthase IUniRule annotation
tRNA-uridine isomerase IUniRule annotation
Gene namesi
Name:truAUniRule annotation
Ordered Locus Names:Pisl_1280
OrganismiPyrobaculum islandicum (strain DSM 4184 / JCM 9189 / GEO3)
Taxonomic identifieri384616 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiThermoprotealesThermoproteaceaePyrobaculum
Proteomesi
  • UP000002595 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000171461 – 255tRNA pseudouridine synthase AAdd BLAST255

Interactioni

Protein-protein interaction databases

STRINGi384616.Pisl_1280

Structurei

3D structure databases

ProteinModelPortaliA1RU12
SMRiA1RU12
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tRNA pseudouridine synthase TruA family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04449 Archaea
COG0101 LUCA
HOGENOMiHOG000248673
KOiK06173
OMAiHYRYILP
OrthoDBiPOG093Z0GCU

Family and domain databases

Gene3Di3.30.70.660, 1 hit
HAMAPiMF_00171 TruA, 1 hit
InterProiView protein in InterPro
IPR020103 PsdUridine_synth_cat_dom_sf
IPR001406 PsdUridine_synth_TruA
IPR020097 PsdUridine_synth_TruA_a/b_dom
IPR020095 PsdUridine_synth_TruA_C
PANTHERiPTHR11142 PTHR11142, 1 hit
PfamiView protein in Pfam
PF01416 PseudoU_synth_1, 1 hit
PIRSFiPIRSF001430 tRNA_psdUrid_synth, 1 hit
SUPFAMiSSF55120 SSF55120, 1 hit

Sequencei

Sequence statusi: Complete.

A1RU12-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPYLYRIAYD GTLFYGFTGH SRSLEPALKR VFGEILGRGS RTDPGVSAVA
60 70 80 90 100
NTVMVSQKLP IALVNSKLPR GVWAWAIAEV PQSFNPRRAK FRHYLYVAPH
110 120 130 140 150
WGEDLGSMHE AAEVLAGTHD FASFIQRRGE KISTIATVME IKVELRGDLI
160 170 180 190 200
YMHFVGRGFK NKMIRKLAWA ILAAGRGIFN IRDIRELLER PRPGVVPSAP
210 220 230 240 250
AEGLVLLNIE YDVDFQIDYT ALRSAYVYFL SKYRHAVAHA AALKAVGETL

ATWEQ
Length:255
Mass (Da):28,636
Last modified:February 6, 2007 - v1
Checksum:iC0EA30C50695F210
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000504 Genomic DNA Translation: ABL88444.1
RefSeqiWP_011763019.1, NC_008701.1

Genome annotation databases

EnsemblBacteriaiABL88444; ABL88444; Pisl_1280
GeneIDi4617461
KEGGipis:Pisl_1280

Similar proteinsi

Entry informationi

Entry nameiTRUA_PYRIL
AccessioniPrimary (citable) accession number: A1RU12
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 6, 2007
Last modified: March 28, 2018
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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