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Protein

tRNA pseudouridine synthase A

Gene

truA

Organism
Pyrobaculum islandicum (strain DSM 4184 / JCM 9189 / GEO3)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.UniRule annotation

Catalytic activityi

tRNA uridine(38-40) = tRNA pseudouridine(38-40).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei43 – 431NucleophileUniRule annotation
Binding sitei94 – 941SubstrateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

tRNA processing

Enzyme and pathway databases

BioCyciPISL384616:GC8H-1310-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA pseudouridine synthase AUniRule annotation (EC:5.4.99.12UniRule annotation)
Alternative name(s):
tRNA pseudouridine(38-40) synthaseUniRule annotation
tRNA pseudouridylate synthase IUniRule annotation
tRNA-uridine isomerase IUniRule annotation
Gene namesi
Name:truAUniRule annotation
Ordered Locus Names:Pisl_1280
OrganismiPyrobaculum islandicum (strain DSM 4184 / JCM 9189 / GEO3)
Taxonomic identifieri384616 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiThermoprotealesThermoproteaceaePyrobaculum
Proteomesi
  • UP000002595 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 255255tRNA pseudouridine synthase APRO_1000017146Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi384616.Pisl_1280.

Structurei

3D structure databases

ProteinModelPortaliA1RU12.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tRNA pseudouridine synthase TruA family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04449. Archaea.
COG0101. LUCA.
HOGENOMiHOG000248673.
KOiK06173.
OMAiTHSFHNL.

Family and domain databases

Gene3Di3.30.70.580. 1 hit.
3.30.70.660. 1 hit.
HAMAPiMF_00171. TruA. 1 hit.
InterProiIPR020103. PsdUridine_synth_cat_dom.
IPR001406. PsdUridine_synth_TruA.
IPR020097. PsdUridine_synth_TruA_a/b_dom.
IPR020095. PsdUridine_synth_TruA_C.
IPR020094. PsdUridine_synth_TruA_N.
[Graphical view]
PANTHERiPTHR11142. PTHR11142. 1 hit.
PfamiPF01416. PseudoU_synth_1. 1 hit.
[Graphical view]
PIRSFiPIRSF001430. tRNA_psdUrid_synth. 1 hit.
SUPFAMiSSF55120. SSF55120. 1 hit.

Sequencei

Sequence statusi: Complete.

A1RU12-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPYLYRIAYD GTLFYGFTGH SRSLEPALKR VFGEILGRGS RTDPGVSAVA
60 70 80 90 100
NTVMVSQKLP IALVNSKLPR GVWAWAIAEV PQSFNPRRAK FRHYLYVAPH
110 120 130 140 150
WGEDLGSMHE AAEVLAGTHD FASFIQRRGE KISTIATVME IKVELRGDLI
160 170 180 190 200
YMHFVGRGFK NKMIRKLAWA ILAAGRGIFN IRDIRELLER PRPGVVPSAP
210 220 230 240 250
AEGLVLLNIE YDVDFQIDYT ALRSAYVYFL SKYRHAVAHA AALKAVGETL

ATWEQ
Length:255
Mass (Da):28,636
Last modified:February 6, 2007 - v1
Checksum:iC0EA30C50695F210
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000504 Genomic DNA. Translation: ABL88444.1.
RefSeqiWP_011763019.1. NC_008701.1.

Genome annotation databases

EnsemblBacteriaiABL88444; ABL88444; Pisl_1280.
GeneIDi4617461.
KEGGipis:Pisl_1280.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000504 Genomic DNA. Translation: ABL88444.1.
RefSeqiWP_011763019.1. NC_008701.1.

3D structure databases

ProteinModelPortaliA1RU12.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi384616.Pisl_1280.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABL88444; ABL88444; Pisl_1280.
GeneIDi4617461.
KEGGipis:Pisl_1280.

Phylogenomic databases

eggNOGiarCOG04449. Archaea.
COG0101. LUCA.
HOGENOMiHOG000248673.
KOiK06173.
OMAiTHSFHNL.

Enzyme and pathway databases

BioCyciPISL384616:GC8H-1310-MONOMER.

Family and domain databases

Gene3Di3.30.70.580. 1 hit.
3.30.70.660. 1 hit.
HAMAPiMF_00171. TruA. 1 hit.
InterProiIPR020103. PsdUridine_synth_cat_dom.
IPR001406. PsdUridine_synth_TruA.
IPR020097. PsdUridine_synth_TruA_a/b_dom.
IPR020095. PsdUridine_synth_TruA_C.
IPR020094. PsdUridine_synth_TruA_N.
[Graphical view]
PANTHERiPTHR11142. PTHR11142. 1 hit.
PfamiPF01416. PseudoU_synth_1. 1 hit.
[Graphical view]
PIRSFiPIRSF001430. tRNA_psdUrid_synth. 1 hit.
SUPFAMiSSF55120. SSF55120. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTRUA_PYRIL
AccessioniPrimary (citable) accession number: A1RU12
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 6, 2007
Last modified: September 7, 2016
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.