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A1RTX9

- SYL_PYRIL

UniProt

A1RTX9 - SYL_PYRIL

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Protein

Leucine--tRNA ligase

Gene
leuS, Pisl_1246
Organism
Pyrobaculum islandicum (strain DSM 4184 / JCM 9189)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei641 – 6411ATP By similarity

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPISL384616:GC8H-1276-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:Pisl_1246
OrganismiPyrobaculum islandicum (strain DSM 4184 / JCM 9189)
Taxonomic identifieri384616 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiThermoprotealesThermoproteaceaePyrobaculum
ProteomesiUP000002595: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 945945Leucine--tRNA ligaseUniRule annotationPRO_1000009405Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi384616.Pisl_1246.

Structurei

3D structure databases

ProteinModelPortaliA1RTX9.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi43 – 5311"HIGH" regionUniRule annotationAdd
BLAST
Motifi638 – 6425"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000216620.
KOiK01869.
OMAiHAPFDYL.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_A. Leu_tRNA_synth_A.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR020791. Leu-tRNA-lgase_arc.
IPR004493. Leu-tRNA-synth_Ia_arc/euk.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
[Graphical view]
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 2 hits.
TIGRFAMsiTIGR00395. leuS_arch. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1RTX9-1 [UniParc]FASTAAdd to Basket

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MSELSRFFIE IAERWQKRWK ESRVFEPEPT PGVAKYFITA AYPYPNGAVH    50
IGHGRTYLIA DVLARFYRHM GRVVLYPMGF HYTGTPILTI AEVIAAGDKT 100
VIEEYMEIYG VPEEEIKKMG DPLYLARYFH NRSKMAMERF GLSIDWTREF 150
TTIDPEYQRF IQWQFEKLRK KGLIVRGRHP VGWCPRHSMP VGAHDTKDDK 200
EPEIGQWTLI YFTDSEGLTF PAATLRPETV PGVTNLWINP DAEYVVAEFD 250
GKRVVISRDA AYRLSFQAEV KILREARGRE FVGRSVQNPV TGEWVPIYEA 300
WFVDPRVGTG VVMSVPAHAP YDYVALRDLG IEKLIPLIKV EGYGDYPAKE 350
VVERMGIKSQ TDPALEEATK EVYSTEYTRG VMREDVTERI GIHLQEPARS 400
MLRAVFKMYF AGRPVREARE FIAKWLVEAR LGGVMYDIMN KPVYCRCGTE 450
IVVKVLEDQW FINYGDPKWK ETARKLVDEM VIIPGEAKAH FFATIDWLDK 500
RACARTRGLG TPLPWSSGWI IESLSDSTIY MAFYTVIKKI RQFGIRPEQL 550
TEEFWDFVFL GQGSADEVSK KTGVPVEALK AIREEFEYWY PLDSRNSGKD 600
LIPNHLTFFI FNHVAIFPRE KWPRQIVANG WVLREGEKMS KSKRNVLPLD 650
RAVEMYGPDP LRATLALAAE VEQDLDFRDA EARRNAQQLM AIYTLVQRLI 700
QNAENRPAGW IDQWLIAEIS RILDKAREAY EKVRVRQAAV EVIYNAKAVF 750
DQYLAMVEKP TKLALEAARA WVVAMEPIVP HIAEELWALL GGSGFVATAP 800
WPRLKAESAA LLAKRYVDML IEDVKNIPAF GPGARRIVIY VNRNFSWAKA 850
ALNGDVKTVV TAGAPPQVAK RLIDLVKTLG DEVRTLLAST EQFDELETLK 900
SYKAYIERTL GTPIEIYSVD DPSAPDLGGK KRAALPLKPG IYIER 945
Length:945
Mass (Da):107,947
Last modified:February 6, 2007 - v1
Checksum:i66351DCA0CEB630D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000504 Genomic DNA. Translation: ABL88411.1.
RefSeqiYP_930754.1. NC_008701.1.

Genome annotation databases

EnsemblBacteriaiABL88411; ABL88411; Pisl_1246.
GeneIDi4616435.
KEGGipis:Pisl_1246.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000504 Genomic DNA. Translation: ABL88411.1 .
RefSeqi YP_930754.1. NC_008701.1.

3D structure databases

ProteinModelPortali A1RTX9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 384616.Pisl_1246.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABL88411 ; ABL88411 ; Pisl_1246 .
GeneIDi 4616435.
KEGGi pis:Pisl_1246.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000216620.
KOi K01869.
OMAi HAPFDYL.

Enzyme and pathway databases

BioCyci PISL384616:GC8H-1276-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_A. Leu_tRNA_synth_A.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR020791. Leu-tRNA-lgase_arc.
IPR004493. Leu-tRNA-synth_Ia_arc/euk.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
[Graphical view ]
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 2 hits.
TIGRFAMsi TIGR00395. leuS_arch. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of Pyrobaculum islandicum DSM 4184."
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Meincke L., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J., Larimer F., Land M.
    , Hauser L., Kyrpides N., Mikhailova N., Lowe T., Richardson P.
    Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 4184 / JCM 9189.

Entry informationi

Entry nameiSYL_PYRIL
AccessioniPrimary (citable) accession number: A1RTX9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 6, 2007
Last modified: May 14, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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