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A1RTK4 (DNLI_PYRIL) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
DNA ligase

EC=6.5.1.1
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]
Gene names
Name:lig
Ordered Locus Names:Pisl_1115
OrganismPyrobaculum islandicum (strain DSM 4184 / JCM 9189) [Complete proteome] [HAMAP]
Taxonomic identifier384616 [NCBI]
Taxonomic lineageArchaeaCrenarchaeotaThermoproteiThermoprotealesThermoproteaceaePyrobaculum

Protein attributes

Sequence length584 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair By similarity. HAMAP-Rule MF_00407

Catalytic activity

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m). HAMAP-Rule MF_00407

Cofactor

Divalent metal cations By similarity. HAMAP-Rule MF_00407

Sequence similarities

Belongs to the ATP-dependent DNA ligase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 584584DNA ligase HAMAP-Rule MF_00407
PRO_1000049877

Sites

Active site2511N6-AMP-lysine intermediate By similarity
Binding site2491ATP By similarity
Binding site2561ATP By similarity
Binding site2711ATP By similarity
Binding site3011ATP By similarity
Binding site3411ATP By similarity
Binding site4161ATP By similarity
Binding site4221ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
A1RTK4 [UniParc].

Last modified February 6, 2007. Version 1.
Checksum: D050BF645449D34A

FASTA58465,093
        10         20         30         40         50         60 
MQFGELVKTL AAVESTTQRT TMVKLLTSLF KKARPEEIDK IIYFVLGDLR PPWEGVELGV 

        70         80         90        100        110        120 
AEKLCLRAVS KATGVSISEL EALYKKTGDV GEAARKALST AKRPGLLAFG QQKPLEVSEV 

       130        140        150        160        170        180 
YDTLLKVAQA SGEGAQDMKI SLLASLFAKA SPEEAKYIAR FVVGKLRLGV ADMTLIEALS 

       190        200        210        220        230        240 
DAFGVDKEAL ERAYHIYPDL GKLARHVAEG RPLEEIKITP GVPVLPMLAQ RLSSSSEILA 

       250        260        270        280        290        300 
KLGGSAICEY KYDGERAQIH LKEGVVKIFS RRLEDITHAY PDVVKAVREA VSAREAILEG 

       310        320        330        340        350        360 
EIVAIDPDTG DMLPFQELMH RKRKHEVAVA VEMYPVVLNL FDLLYIDGED LTNEPLIYRR 

       370        380        390        400        410        420 
VRLSEVVQET EKVSIAKWRV FDDAEEIDVF FHEAVSLGME GLVCKSPTSV YEMGARGWNW 

       430        440        450        460        470        480 
IKYKRDYKSE MIDTVDLVVV GAFYGRGKRA GLYGAFLLAA YDPATDMFYT VCKVGSGFTD 

       490        500        510        520        530        540 
ADLKKMYEML QPYKIPHRHP RVVSKMEPDV WFTPQVVIEV IGAEITLSPL HTCCLGAVKP 

       550        560        570        580 
GVGLAIRFPR FTGRYRTDKS PEQATTVSEM IELYKRQKKV AQPE 

« Hide

References

[1]"Complete sequence of Pyrobaculum islandicum DSM 4184."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Meincke L., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J., Larimer F., Land M. expand/collapse author list , Hauser L., Kyrpides N., Mikhailova N., Lowe T., Richardson P.
Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 4184 / JCM 9189.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000504 Genomic DNA. Translation: ABL88286.1.
RefSeqYP_930629.1. NC_008701.1.

3D structure databases

ProteinModelPortalA1RTK4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING384616.Pisl_1115.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABL88286; ABL88286; Pisl_1115.
GeneID4616742.
KEGGpis:Pisl_1115.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1793.
HOGENOMHOG000036008.
KOK10747.
OMAYIARFVV.
ProtClustDBPRK01109.

Enzyme and pathway databases

BioCycPISL384616:GC8H-1143-MONOMER.

Family and domain databases

Gene3D1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPMF_00407. DNA_ligase.
InterProIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsTIGR00574. dnl1. 1 hit.
PROSITEPS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDNLI_PYRIL
AccessionPrimary (citable) accession number: A1RTK4
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 6, 2007
Last modified: February 19, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families