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A1RTK4

- DNLI_PYRIL

UniProt

A1RTK4 - DNLI_PYRIL

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Protein

DNA ligase

Gene

lig

Organism
Pyrobaculum islandicum (strain DSM 4184 / JCM 9189)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

Cofactori

a divalent metal cationUniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei249 – 2491ATPUniRule annotation
Active sitei251 – 2511N6-AMP-lysine intermediateUniRule annotation
Binding sitei256 – 2561ATPUniRule annotation
Binding sitei271 – 2711ATPUniRule annotation
Binding sitei301 – 3011ATPUniRule annotation
Binding sitei341 – 3411ATPUniRule annotation
Binding sitei416 – 4161ATPUniRule annotation
Binding sitei422 – 4221ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
  4. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. DNA biosynthetic process Source: InterPro
  4. DNA ligation involved in DNA repair Source: InterPro
  5. DNA recombination Source: UniProtKB-HAMAP
  6. DNA replication Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Cell cycle, Cell division, DNA damage, DNA recombination, DNA repair, DNA replication

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPISL384616:GC8H-1143-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]UniRule annotation
Gene namesi
Name:ligUniRule annotation
Ordered Locus Names:Pisl_1115
OrganismiPyrobaculum islandicum (strain DSM 4184 / JCM 9189)
Taxonomic identifieri384616 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiThermoprotealesThermoproteaceaePyrobaculum
ProteomesiUP000002595: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 584584DNA ligasePRO_1000049877Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi384616.Pisl_1115.

Structurei

3D structure databases

ProteinModelPortaliA1RTK4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1793.
HOGENOMiHOG000036008.
KOiK10747.
OMAiRVWLWSR.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPiMF_00407. DNA_ligase.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1RTK4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQFGELVKTL AAVESTTQRT TMVKLLTSLF KKARPEEIDK IIYFVLGDLR
60 70 80 90 100
PPWEGVELGV AEKLCLRAVS KATGVSISEL EALYKKTGDV GEAARKALST
110 120 130 140 150
AKRPGLLAFG QQKPLEVSEV YDTLLKVAQA SGEGAQDMKI SLLASLFAKA
160 170 180 190 200
SPEEAKYIAR FVVGKLRLGV ADMTLIEALS DAFGVDKEAL ERAYHIYPDL
210 220 230 240 250
GKLARHVAEG RPLEEIKITP GVPVLPMLAQ RLSSSSEILA KLGGSAICEY
260 270 280 290 300
KYDGERAQIH LKEGVVKIFS RRLEDITHAY PDVVKAVREA VSAREAILEG
310 320 330 340 350
EIVAIDPDTG DMLPFQELMH RKRKHEVAVA VEMYPVVLNL FDLLYIDGED
360 370 380 390 400
LTNEPLIYRR VRLSEVVQET EKVSIAKWRV FDDAEEIDVF FHEAVSLGME
410 420 430 440 450
GLVCKSPTSV YEMGARGWNW IKYKRDYKSE MIDTVDLVVV GAFYGRGKRA
460 470 480 490 500
GLYGAFLLAA YDPATDMFYT VCKVGSGFTD ADLKKMYEML QPYKIPHRHP
510 520 530 540 550
RVVSKMEPDV WFTPQVVIEV IGAEITLSPL HTCCLGAVKP GVGLAIRFPR
560 570 580
FTGRYRTDKS PEQATTVSEM IELYKRQKKV AQPE
Length:584
Mass (Da):65,093
Last modified:February 6, 2007 - v1
Checksum:iD050BF645449D34A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000504 Genomic DNA. Translation: ABL88286.1.
RefSeqiYP_930629.1. NC_008701.1.

Genome annotation databases

EnsemblBacteriaiABL88286; ABL88286; Pisl_1115.
GeneIDi4616742.
KEGGipis:Pisl_1115.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000504 Genomic DNA. Translation: ABL88286.1 .
RefSeqi YP_930629.1. NC_008701.1.

3D structure databases

ProteinModelPortali A1RTK4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 384616.Pisl_1115.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABL88286 ; ABL88286 ; Pisl_1115 .
GeneIDi 4616742.
KEGGi pis:Pisl_1115.

Phylogenomic databases

eggNOGi COG1793.
HOGENOMi HOG000036008.
KOi K10747.
OMAi RVWLWSR.

Enzyme and pathway databases

BioCyci PISL384616:GC8H-1143-MONOMER.

Family and domain databases

Gene3Di 1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPi MF_00407. DNA_ligase.
InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view ]
Pfami PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view ]
SUPFAMi SSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00574. dnl1. 1 hit.
PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of Pyrobaculum islandicum DSM 4184."
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Meincke L., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J., Larimer F., Land M.
    , Hauser L., Kyrpides N., Mikhailova N., Lowe T., Richardson P.
    Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 4184 / JCM 9189.

Entry informationi

Entry nameiDNLI_PYRIL
AccessioniPrimary (citable) accession number: A1RTK4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 6, 2007
Last modified: November 26, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3