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A1RTK4

- DNLI_PYRIL

UniProt

A1RTK4 - DNLI_PYRIL

Protein

DNA ligase

Gene

lig

Organism
Pyrobaculum islandicum (strain DSM 4184 / JCM 9189)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 54 (01 Oct 2014)
      Sequence version 1 (06 Feb 2007)
      Previous versions | rss
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    Functioni

    DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

    Catalytic activityi

    ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

    Cofactori

    Divalent metal cations.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei249 – 2491ATPUniRule annotation
    Active sitei251 – 2511N6-AMP-lysine intermediateUniRule annotation
    Binding sitei256 – 2561ATPUniRule annotation
    Binding sitei271 – 2711ATPUniRule annotation
    Binding sitei301 – 3011ATPUniRule annotation
    Binding sitei341 – 3411ATPUniRule annotation
    Binding sitei416 – 4161ATPUniRule annotation
    Binding sitei422 – 4221ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. DNA binding Source: InterPro
    3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
    4. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW
    3. DNA ligation involved in DNA repair Source: InterPro
    4. DNA recombination Source: UniProtKB-HAMAP
    5. DNA replication Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Cell cycle, Cell division, DNA damage, DNA recombination, DNA repair, DNA replication

    Keywords - Ligandi

    ATP-binding, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciPISL384616:GC8H-1143-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
    Alternative name(s):
    Polydeoxyribonucleotide synthase [ATP]UniRule annotation
    Gene namesi
    Name:ligUniRule annotation
    Ordered Locus Names:Pisl_1115
    OrganismiPyrobaculum islandicum (strain DSM 4184 / JCM 9189)
    Taxonomic identifieri384616 [NCBI]
    Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiThermoprotealesThermoproteaceaePyrobaculum
    ProteomesiUP000002595: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 584584DNA ligasePRO_1000049877Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi384616.Pisl_1115.

    Structurei

    3D structure databases

    ProteinModelPortaliA1RTK4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ATP-dependent DNA ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1793.
    HOGENOMiHOG000036008.
    KOiK10747.
    OMAiRVWLWSR.

    Family and domain databases

    Gene3Di1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    HAMAPiMF_00407. DNA_ligase.
    InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view]
    PfamiPF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsiTIGR00574. dnl1. 1 hit.
    PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A1RTK4-1 [UniParc]FASTAAdd to Basket

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    MQFGELVKTL AAVESTTQRT TMVKLLTSLF KKARPEEIDK IIYFVLGDLR    50
    PPWEGVELGV AEKLCLRAVS KATGVSISEL EALYKKTGDV GEAARKALST 100
    AKRPGLLAFG QQKPLEVSEV YDTLLKVAQA SGEGAQDMKI SLLASLFAKA 150
    SPEEAKYIAR FVVGKLRLGV ADMTLIEALS DAFGVDKEAL ERAYHIYPDL 200
    GKLARHVAEG RPLEEIKITP GVPVLPMLAQ RLSSSSEILA KLGGSAICEY 250
    KYDGERAQIH LKEGVVKIFS RRLEDITHAY PDVVKAVREA VSAREAILEG 300
    EIVAIDPDTG DMLPFQELMH RKRKHEVAVA VEMYPVVLNL FDLLYIDGED 350
    LTNEPLIYRR VRLSEVVQET EKVSIAKWRV FDDAEEIDVF FHEAVSLGME 400
    GLVCKSPTSV YEMGARGWNW IKYKRDYKSE MIDTVDLVVV GAFYGRGKRA 450
    GLYGAFLLAA YDPATDMFYT VCKVGSGFTD ADLKKMYEML QPYKIPHRHP 500
    RVVSKMEPDV WFTPQVVIEV IGAEITLSPL HTCCLGAVKP GVGLAIRFPR 550
    FTGRYRTDKS PEQATTVSEM IELYKRQKKV AQPE 584
    Length:584
    Mass (Da):65,093
    Last modified:February 6, 2007 - v1
    Checksum:iD050BF645449D34A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000504 Genomic DNA. Translation: ABL88286.1.
    RefSeqiYP_930629.1. NC_008701.1.

    Genome annotation databases

    EnsemblBacteriaiABL88286; ABL88286; Pisl_1115.
    GeneIDi4616742.
    KEGGipis:Pisl_1115.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000504 Genomic DNA. Translation: ABL88286.1 .
    RefSeqi YP_930629.1. NC_008701.1.

    3D structure databases

    ProteinModelPortali A1RTK4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 384616.Pisl_1115.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABL88286 ; ABL88286 ; Pisl_1115 .
    GeneIDi 4616742.
    KEGGi pis:Pisl_1115.

    Phylogenomic databases

    eggNOGi COG1793.
    HOGENOMi HOG000036008.
    KOi K10747.
    OMAi RVWLWSR.

    Enzyme and pathway databases

    BioCyci PISL384616:GC8H-1143-MONOMER.

    Family and domain databases

    Gene3Di 1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    HAMAPi MF_00407. DNA_ligase.
    InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view ]
    Pfami PF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsi TIGR00574. dnl1. 1 hit.
    PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of Pyrobaculum islandicum DSM 4184."
      Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Meincke L., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J., Larimer F., Land M.
      , Hauser L., Kyrpides N., Mikhailova N., Lowe T., Richardson P.
      Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 4184 / JCM 9189.

    Entry informationi

    Entry nameiDNLI_PYRIL
    AccessioniPrimary (citable) accession number: A1RTK4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: February 6, 2007
    Last modified: October 1, 2014
    This is version 54 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3