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Protein

Geranylgeranylglyceryl phosphate synthase

Gene

Pisl_0443

Organism
Pyrobaculum islandicum (strain DSM 4184 / JCM 9189 / GEO3)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids.UniRule annotation

Catalytic activityi

Geranylgeranyl diphosphate + sn-glycerol 1-phosphate = diphosphate + sn-3-O-(geranylgeranyl)glycerol 1-phosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Pathwayi: glycerophospholipid metabolism

This protein is involved in the pathway glycerophospholipid metabolism, which is part of Membrane lipid metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway glycerophospholipid metabolism and in Membrane lipid metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi18 – 181MagnesiumUniRule annotation
Metal bindingi45 – 451MagnesiumUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciPISL384616:GC8H-452-MONOMER.
UniPathwayiUPA00940.

Names & Taxonomyi

Protein namesi
Recommended name:
Geranylgeranylglyceryl phosphate synthaseUniRule annotation (EC:2.5.1.41UniRule annotation)
Short name:
GGGP synthaseUniRule annotation
Short name:
GGGPSUniRule annotation
Alternative name(s):
(S)-3-O-geranylgeranylglyceryl phosphate synthaseUniRule annotation
Phosphoglycerol geranylgeranyltransferaseUniRule annotation
Gene namesi
Ordered Locus Names:Pisl_0443
OrganismiPyrobaculum islandicum (strain DSM 4184 / JCM 9189 / GEO3)
Taxonomic identifieri384616 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiThermoprotealesThermoproteaceaePyrobaculum
Proteomesi
  • UP000002595 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 239239Geranylgeranylglyceryl phosphate synthasePRO_0000304188Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi384616.Pisl_0443.

Structurei

3D structure databases

ProteinModelPortaliA1RRN9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni166 – 1727Glycerol-1-phosphate bindingUniRule annotation
Regioni197 – 1982Glycerol-1-phosphate bindingUniRule annotation
Regioni219 – 2202Glycerol-1-phosphate bindingUniRule annotation

Sequence similaritiesi

Belongs to the GGGP/HepGP synthase family. Group II subfamily.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01085. Archaea.
COG1646. LUCA.
HOGENOMiHOG000034117.
KOiK17104.
OMAiEPIPMAY.

Family and domain databases

Gene3Di3.20.20.390. 1 hit.
HAMAPiMF_00112. GGGP_HepGP_synthase. 1 hit.
InterProiIPR008205. GGGP_HepGP_synthase.
IPR010946. GGGP_synth.
[Graphical view]
PfamiPF01884. PcrB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01769. GGGP. 1 hit.
TIGR01768. GGGP-family. 1 hit.

Sequencei

Sequence statusi: Complete.

A1RRN9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLYEYLVEG TKHFTLIDPD KSVDYLKIAK YALEAGTDGI LVGGSLGIRE
60 70 80 90 100
SQITQVVKDI KSIAHVPVVI FPGSISQLTD EADGVLFLSV LNSLDPYYII
110 120 130 140 150
GAQIQGAVLL AKHYPKLEVI STAYIIIGDG GAAGFVSMSK PIPYTRPDIV
160 170 180 190 200
MAYALAANYI GFKAVYLEAG SGAPQPAPPE MVRAARRVFP RILIVGGGIR
210 220 230
SGEVAYTIAR EKPNVIVTGT LAEEKPEKLG EIIRAIKSA
Length:239
Mass (Da):25,604
Last modified:February 6, 2007 - v1
Checksum:i77E56D6FA5A2248A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000504 Genomic DNA. Translation: ABL87621.1.
RefSeqiWP_011762198.1. NC_008701.1.

Genome annotation databases

EnsemblBacteriaiABL87621; ABL87621; Pisl_0443.
GeneIDi4617622.
KEGGipis:Pisl_0443.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000504 Genomic DNA. Translation: ABL87621.1.
RefSeqiWP_011762198.1. NC_008701.1.

3D structure databases

ProteinModelPortaliA1RRN9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi384616.Pisl_0443.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABL87621; ABL87621; Pisl_0443.
GeneIDi4617622.
KEGGipis:Pisl_0443.

Phylogenomic databases

eggNOGiarCOG01085. Archaea.
COG1646. LUCA.
HOGENOMiHOG000034117.
KOiK17104.
OMAiEPIPMAY.

Enzyme and pathway databases

UniPathwayiUPA00940.
BioCyciPISL384616:GC8H-452-MONOMER.

Family and domain databases

Gene3Di3.20.20.390. 1 hit.
HAMAPiMF_00112. GGGP_HepGP_synthase. 1 hit.
InterProiIPR008205. GGGP_HepGP_synthase.
IPR010946. GGGP_synth.
[Graphical view]
PfamiPF01884. PcrB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01769. GGGP. 1 hit.
TIGR01768. GGGP-family. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiGGGPS_PYRIL
AccessioniPrimary (citable) accession number: A1RRN9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: February 6, 2007
Last modified: July 6, 2016
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.