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A1RR78 (ARLY_PYRIL) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 37. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Argininosuccinate lyase
Short name=ASAL
EC=4.3.2.1
Alternative name(s):
Arginosuccinase
Gene names
Name:argH
Ordered Locus Names:Pisl_0281
OrganismPyrobaculum islandicum (strain DSM 4184 / JCM 9189) [Complete proteome] [HAMAP]
Taxonomic identifier384616 [NCBI]
Taxonomic lineageArchaea › Crenarchaeota › Thermoprotei › Thermoproteales › Thermoproteaceae › Pyrobaculum

Protein attributes

Sequence length429 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

2-(N(omega)-L-arginino)succinate = fumarate + L-arginine. HAMAP MF_00006

Pathway

Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3. HAMAP MF_00006

Subcellular location

Cytoplasm By similarity HAMAP MF_00006.

Sequence similarities

Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Arginine biosynthesis
   Cellular componentCytoplasm
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processarginine biosynthetic process via ornithine

Inferred from electronic annotation. Source: InterPro

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionargininosuccinate lyase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 429429Argininosuccinate lyase HAMAP MF_00006
PRO_1000089106

Sequences

Sequence LengthMass (Da)Tools
A1RR78 [UniParc].

Last modified February 6, 2007. Version 1.
Checksum: 30644D6F08D9B740

FASTA42947,481
        10         20         30         40         50         60 
MSFYRSWIGE EGELIKRYTS SIKDDVEIAE EVIKVMEAHV KHLAEVGIMP KEAADAILKT 

        70         80         90        100        110        120 
LKEATPEQLL SSEFEDIHEA LEKWLIDRLG EETAGWVGLG RSRNDHVAAA IRLAALRKAS 

       130        140        150        160        170        180 
ALRKNVEKMR CILAKKALEY ADCAMPSFTH FQPAQAITFG HYLLAVDELA AEFLHVLKAV 

       190        200        210        220        230        240 
EKLLKRSPLG AGPAGGTRTP IDRERLAKLA GFEDVVENAL YASGSRFFAL ALASAVVSFL 

       250        260        270        280        290        300 
TELSRTVDDL IRWNSPLVGY VAAPDSHVST SSIMPHKRNL VTLEVFRARA AEALGHLTAL 

       310        320        330        340        350        360 
NAVVMKIGLG YSLDLQEATR HLWAVLNMAT EGVEIFIDFL EKMSFNCVKA REDAERYHST 

       370        380        390        400        410        420 
SSDTAETIAL SGVPFRKAYF QLAKEIKEGT ARLMSIEEAL QRPTRGSANP EEVKKAASTR 


LVFCREKPL

« Hide

References

[1]"Complete sequence of Pyrobaculum islandicum DSM 4184."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Meincke L., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J., Larimer F., Land M. expand/collapse author list , Hauser L., Kyrpides N., Mikhailova N., Lowe T., Richardson P.
Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 4184 / JCM 9189.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000504 Genomic DNA. Translation: ABL87460.1.
RefSeqYP_929803.1. NC_008701.1.

3D structure databases

ProteinModelPortalA1RR78.
ModBaseSearch...

Protein-protein interaction databases

STRINGA1RR78.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4616786.
GenomeReviewsGene locus Pisl_0281 in contig CP000504_GR.
KEGGpis:Pisl_0281.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGarNOG04975.
HOGENOMHBG539632.
OMAMPGRTHL.
ProtClustDBPRK00855.

Enzyme and pathway databases

BioCycPISL384616:PISL_0281-MONOMER.

Family and domain databases

HAMAPMF_00006. Arg_succ_lyase.
[Tree]
InterProIPR009049. Argininosuccinate_lyase.
IPR003031. D_crystallin.
IPR000362. Fumarate_lyase.
IPR008948. L-Aspartase-like.
IPR022761. Lyase1_N.
[Graphical view]
KOK01755.
PANTHERPTHR11444:SF3. argH. 1 hit.
PfamPF00206. Lyase_1. 1 hit.
[Graphical view]
PRINTSPR00145. ARGSUCLYASE.
PR00149. FUMRATELYASE.
SUPFAMSSF48557. L-Aspartase-like. 1 hit.
TIGRFAMsTIGR00838. ArgH. 1 hit.
PROSITEPS00163. FUMARATE_LYASES. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameARLY_PYRIL
AccessionPrimary (citable) accession number: A1RR78
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: February 6, 2007
Last modified: November 16, 2011
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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