Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

A1RQR5

- GSA_PYRIL

UniProt

A1RQR5 - GSA_PYRIL

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Glutamate-1-semialdehyde 2,1-aminomutase

Gene

hemL

Organism
Pyrobaculum islandicum (strain DSM 4184 / JCM 9189)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-4-amino-5-oxopentanoate = 5-aminolevulinate.UniRule annotation

Cofactori

Pyridoxal phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. glutamate-1-semialdehyde 2,1-aminomutase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: InterPro
  3. transaminase activity Source: InterPro

GO - Biological processi

  1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Porphyrin biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciPISL384616:GC8H-117-MONOMER.
UniPathwayiUPA00251; UER00317.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate-1-semialdehyde 2,1-aminomutaseUniRule annotation (EC:5.4.3.8UniRule annotation)
Short name:
GSAUniRule annotation
Alternative name(s):
Glutamate-1-semialdehyde aminotransferaseUniRule annotation
Short name:
GSA-ATUniRule annotation
Gene namesi
Name:hemLUniRule annotation
Ordered Locus Names:Pisl_0114
OrganismiPyrobaculum islandicum (strain DSM 4184 / JCM 9189)
Taxonomic identifieri384616 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiThermoprotealesThermoproteaceaePyrobaculum
ProteomesiUP000002595: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 424424Glutamate-1-semialdehyde 2,1-aminomutasePRO_0000382412Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei258 – 2581N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi384616.Pisl_0114.

Structurei

3D structure databases

ProteinModelPortaliA1RQR5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0001.
HOGENOMiHOG000020210.
KOiK01845.
OMAiLMAHIAP.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPiMF_00375. HemL_aminotrans_3.
InterProiIPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11986. PTHR11986. 1 hit.
PfamiPF00202. Aminotran_3. 1 hit.
[Graphical view]
PIRSFiPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR00713. hemL. 1 hit.
PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1RQR5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLFERARGVF PGGVNSPARA LKHLAAPLVA KGASGPYLYT DRGRLVDYCM
60 70 80 90 100
AFGAIILGHA HPRVKNAVTQ QLERGWIYAL LTEEEVAYAE RIKAHVPSIE
110 120 130 140 150
KMRIVNSGTE ATMNAVRLAR GYTRRDVIIK FDGNFHGSHD YVLVKAGSGA
160 170 180 190 200
ATWGIPTSAG VPQDVIKLTA VVPYNDVDAF VKTVREIGGR LAAVIVEPIA
210 220 230 240 250
ANYGLIIPDR EFIKALKEET ERVGALLIFD EVVTGFRVGL SGAQGHFGVR
260 270 280 290 300
PDLTTLGKVV GGGFPIGIFG GRADVMDMVA PSGPVYNAGT YNAHPVSVAA
310 320 330 340 350
GLAVIEELEK GEPYKIANEA AERLAKGIED IAGRAGFDVV VKQIASMFQL
360 370 380 390 400
YFKRGDVKTP QDVRESDEKL YLKLHELAIK HGVYLAPSQY ETNFTSAAHT
410 420
QDVVETTLAA LEKAFTELKS QVGK
Length:424
Mass (Da):45,776
Last modified:February 6, 2007 - v1
Checksum:iA9C94BB2BD336712
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000504 Genomic DNA. Translation: ABL87297.1.
RefSeqiWP_011761874.1. NC_008701.1.
YP_929640.1. NC_008701.1.

Genome annotation databases

EnsemblBacteriaiABL87297; ABL87297; Pisl_0114.
GeneIDi4617546.
KEGGipis:Pisl_0114.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000504 Genomic DNA. Translation: ABL87297.1 .
RefSeqi WP_011761874.1. NC_008701.1.
YP_929640.1. NC_008701.1.

3D structure databases

ProteinModelPortali A1RQR5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 384616.Pisl_0114.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABL87297 ; ABL87297 ; Pisl_0114 .
GeneIDi 4617546.
KEGGi pis:Pisl_0114.

Phylogenomic databases

eggNOGi COG0001.
HOGENOMi HOG000020210.
KOi K01845.
OMAi LMAHIAP.

Enzyme and pathway databases

UniPathwayi UPA00251 ; UER00317 .
BioCyci PISL384616:GC8H-117-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPi MF_00375. HemL_aminotrans_3.
InterProi IPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
PANTHERi PTHR11986. PTHR11986. 1 hit.
Pfami PF00202. Aminotran_3. 1 hit.
[Graphical view ]
PIRSFi PIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
TIGRFAMsi TIGR00713. hemL. 1 hit.
PROSITEi PS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of Pyrobaculum islandicum DSM 4184."
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Meincke L., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J., Larimer F., Land M.
    , Hauser L., Kyrpides N., Mikhailova N., Lowe T., Richardson P.
    Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 4184 / JCM 9189.

Entry informationi

Entry nameiGSA_PYRIL
AccessioniPrimary (citable) accession number: A1RQR5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 1, 2009
Last sequence update: February 6, 2007
Last modified: October 29, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3