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A1RPR6

- ASSY_SHESW

UniProt

A1RPR6 - ASSY_SHESW

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Protein

Argininosuccinate synthase

Gene
argG, Sputw3181_3857
Organism
Shewanella sp. (strain W3-18-1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei44 – 441ATP; via amide nitrogen and carbonyl oxygen By similarity
Binding sitei96 – 961Citrulline By similarity
Binding sitei101 – 1011Citrulline By similarity
Binding sitei126 – 1261ATP; via amide nitrogen By similarity
Binding sitei128 – 1281Aspartate By similarity
Binding sitei132 – 1321Aspartate By similarity
Binding sitei132 – 1321Citrulline By similarity
Binding sitei133 – 1331Aspartate By similarity
Binding sitei136 – 1361Citrulline By similarity
Binding sitei185 – 1851Citrulline By similarity
Binding sitei194 – 1941Citrulline By similarity
Binding sitei270 – 2701Citrulline By similarity
Binding sitei282 – 2821Citrulline By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi16 – 249ATP By similarity

GO - Molecular functioni

  1. argininosuccinate synthase activity Source: UniProtKB-HAMAP
  2. ATP binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. arginine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSSP351745:GCOY-3973-MONOMER.
UniPathwayiUPA00068; UER00113.

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate synthase (EC:6.3.4.5)
Alternative name(s):
Citrulline--aspartate ligase
Gene namesi
Name:argG
Ordered Locus Names:Sputw3181_3857
OrganismiShewanella sp. (strain W3-18-1)
Taxonomic identifieri351745 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
ProteomesiUP000002597: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 407407Argininosuccinate synthaseUniRule annotationPRO_1000000436Add
BLAST

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi351745.Sputw3181_3857.

Structurei

3D structure databases

ProteinModelPortaliA1RPR6.
SMRiA1RPR6. Positions 12-406.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0137.
HOGENOMiHOG000230093.
KOiK01940.
OMAiAPPEEAY.
OrthoDBiEOG6K9QCV.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPiMF_00005. Arg_succ_synth_type1.
InterProiIPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF00764. Arginosuc_synth. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00032. argG. 1 hit.
PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1RPR6-1 [UniParc]FASTAAdd to Basket

« Hide

MSIENKNTGV KKVVLAYSGG LDTSAIIPWL KENYDNCEII AFCADVGQGE    50
EELVGLTEKA LASGASECHI VDLKEEFVKD YIYPTMATGA IYEGTYLLGT 100
SMARPIIAKA QVEVARKVGA DALCHGCTGK GNDQVRFEGC FAALAPDLKV 150
IAPWREWTMQ SREDLLDYLA ERNIKTSASA TKIYSRDANA FHISHEGGEL 200
EDPWNEPSKG VWTLTADPED APNQPEYVSL EVENGRVTKV NGEALTPYAA 250
LMKLNAIAAP HGVGRIDITE NRLVGMKSRG CYETPGGTVM FAALRAIEEL 300
VLDKTSRTWR EQVGAQMAHL VYDGRWFTPL CKSLLAASES LAESVNGGVV 350
VKLYKGHAIA VKKRSPNSLY SEAFATFGED QVYDQKHAEG FIRLYSLASR 400
IRALNAK 407
Length:407
Mass (Da):44,510
Last modified:February 6, 2007 - v1
Checksum:iDE3E33F513E186A4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000503 Genomic DNA. Translation: ABM26661.1.
RefSeqiWP_011791085.1. NC_008750.1.
YP_965215.1. NC_008750.1.

Genome annotation databases

EnsemblBacteriaiABM26661; ABM26661; Sputw3181_3857.
GeneIDi4661468.
KEGGishw:Sputw3181_3857.
PATRICi23601672. VBISheSp103602_4041.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000503 Genomic DNA. Translation: ABM26661.1 .
RefSeqi WP_011791085.1. NC_008750.1.
YP_965215.1. NC_008750.1.

3D structure databases

ProteinModelPortali A1RPR6.
SMRi A1RPR6. Positions 12-406.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 351745.Sputw3181_3857.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABM26661 ; ABM26661 ; Sputw3181_3857 .
GeneIDi 4661468.
KEGGi shw:Sputw3181_3857.
PATRICi 23601672. VBISheSp103602_4041.

Phylogenomic databases

eggNOGi COG0137.
HOGENOMi HOG000230093.
KOi K01940.
OMAi APPEEAY.
OrthoDBi EOG6K9QCV.

Enzyme and pathway databases

UniPathwayi UPA00068 ; UER00113 .
BioCyci SSP351745:GCOY-3973-MONOMER.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPi MF_00005. Arg_succ_synth_type1.
InterProi IPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
Pfami PF00764. Arginosuc_synth. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00032. argG. 1 hit.
PROSITEi PS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: W3-18-1.

Entry informationi

Entry nameiASSY_SHESW
AccessioniPrimary (citable) accession number: A1RPR6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 6, 2007
Last modified: September 3, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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