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Protein

Phosphoribosylaminoimidazole-succinocarboxamide synthase

Gene

purC

Organism
Shewanella sp. (strain W3-18-1)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate = ADP + phosphate + (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate.UniRule annotation

Pathwayi: IMP biosynthesis via de novo pathway

This protein is involved in step 1 of the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Phosphoribosylaminoimidazole-succinocarboxamide synthase (purC)
  2. no protein annotated in this organism
This subpathway is part of the pathway IMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate, the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Purine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSSP351745:GCOY-3667-MONOMER.
UniPathwayiUPA00074; UER00131.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylaminoimidazole-succinocarboxamide synthaseUniRule annotation (EC:6.3.2.6UniRule annotation)
Alternative name(s):
SAICAR synthetaseUniRule annotation
Gene namesi
Name:purCUniRule annotation
Ordered Locus Names:Sputw3181_3563
OrganismiShewanella sp. (strain W3-18-1)
Taxonomic identifieri351745 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 367367Phosphoribosylaminoimidazole-succinocarboxamide synthasePRO_1000117856Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliA1RNX8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SAICAR synthetase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000230361.
KOiK01923.
OMAiHFPDPDI.
OrthoDBiEOG6DG2PN.

Family and domain databases

Gene3Di3.30.470.20. 1 hit.
HAMAPiMF_00137. SAICAR_synth.
InterProiIPR013816. ATP_grasp_subdomain_2.
IPR028923. SAICAR_synt/ADE2_N.
IPR014106. SAICAR_synthase_Vibrio-typ.
IPR018236. SAICAR_synthetase_CS.
[Graphical view]
PfamiPF01259. SAICAR_synt. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02735. purC_vibrio. 1 hit.
PROSITEiPS01057. SAICAR_SYNTHETASE_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1RNX8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLADSVLAV NNDLPIRTDS PVHSGKVRSV YWLTDADSRR LIKTKGYNVP
60 70 80 90 100
EDTPLAIMVI SDRISAFDCI FHGEGGLKGI PGKGAALNAI SNHWFKLFAE
110 120 130 140 150
NGLADSHILD IPHPFVWIVQ KARPIKVEAI CRQYITGSMW RAYSKGERVF
160 170 180 190 200
CGITLPEGLE KDQKLPDLLI TPSTKGILTG IPGVPAQDDI NISRSDIEAN
210 220 230 240 250
YQAFGFEKLE DIDLYEKLLK DGFKVISKAL ADIDQVFVDT KFEFGYVTDK
260 270 280 290 300
DGNSKLIYMD EVGTPDSSRI WDGAAYRDGK ILENSKEGFR QFLLNHFPDP
310 320 330 340 350
DVLLNKDRMP EREALARDND LPLEAMMQVS RTYTGVAEKV TGAAIPLPAN
360
PKADIIKILR EEYDLIL
Length:367
Mass (Da):40,915
Last modified:February 6, 2007 - v1
Checksum:iCF2A907D81FE65B9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000503 Genomic DNA. Translation: ABM26373.1.
RefSeqiWP_011790804.1. NC_008750.1.

Genome annotation databases

EnsemblBacteriaiABM26373; ABM26373; Sputw3181_3563.
KEGGishw:Sputw3181_3563.
PATRICi23601036. VBISheSp103602_3734.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000503 Genomic DNA. Translation: ABM26373.1.
RefSeqiWP_011790804.1. NC_008750.1.

3D structure databases

ProteinModelPortaliA1RNX8.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABM26373; ABM26373; Sputw3181_3563.
KEGGishw:Sputw3181_3563.
PATRICi23601036. VBISheSp103602_3734.

Phylogenomic databases

HOGENOMiHOG000230361.
KOiK01923.
OMAiHFPDPDI.
OrthoDBiEOG6DG2PN.

Enzyme and pathway databases

UniPathwayiUPA00074; UER00131.
BioCyciSSP351745:GCOY-3667-MONOMER.

Family and domain databases

Gene3Di3.30.470.20. 1 hit.
HAMAPiMF_00137. SAICAR_synth.
InterProiIPR013816. ATP_grasp_subdomain_2.
IPR028923. SAICAR_synt/ADE2_N.
IPR014106. SAICAR_synthase_Vibrio-typ.
IPR018236. SAICAR_synthetase_CS.
[Graphical view]
PfamiPF01259. SAICAR_synt. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02735. purC_vibrio. 1 hit.
PROSITEiPS01057. SAICAR_SYNTHETASE_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: W3-18-1.

Entry informationi

Entry nameiPUR7_SHESW
AccessioniPrimary (citable) accession number: A1RNX8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: February 6, 2007
Last modified: November 11, 2015
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.