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Protein

Fructose-1,6-bisphosphatase class 1

Gene

fbp

Organism
Shewanella sp. (strain W3-18-1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-fructose 1,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate.UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 2 magnesium ions per subunit.UniRule annotation

Pathwayi: gluconeogenesis

This protein is involved in the pathway gluconeogenesis, which is part of Carbohydrate biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway gluconeogenesis and in Carbohydrate biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi84 – 841Magnesium 1UniRule annotation
Metal bindingi103 – 1031Magnesium 1UniRule annotation
Metal bindingi103 – 1031Magnesium 2UniRule annotation
Metal bindingi105 – 1051Magnesium 1; via carbonyl oxygenUniRule annotation
Metal bindingi106 – 1061Magnesium 2UniRule annotation
Binding sitei196 – 1961SubstrateUniRule annotation
Binding sitei262 – 2621SubstrateUniRule annotation
Metal bindingi268 – 2681Magnesium 2UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Carbohydrate metabolism

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciSSP351745:GCOY-3600-MONOMER.
UniPathwayiUPA00138.

Names & Taxonomyi

Protein namesi
Recommended name:
Fructose-1,6-bisphosphatase class 1UniRule annotation (EC:3.1.3.11UniRule annotation)
Short name:
FBPase class 1UniRule annotation
Alternative name(s):
D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1UniRule annotation
Gene namesi
Name:fbpUniRule annotation
Ordered Locus Names:Sputw3181_3495
OrganismiShewanella sp. (strain W3-18-1)
Taxonomic identifieri351745 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 330330Fructose-1,6-bisphosphatase class 1PRO_0000364714Add
BLAST

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliA1RNR2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni106 – 1094Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the FBPase class 1 family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000191264.
KOiK03841.
OMAiYTTRYIG.
OrthoDBiEOG6X10TR.

Family and domain databases

HAMAPiMF_01855. FBPase_class1.
InterProiIPR000146. FBPase_class-1.
IPR033391. FBPase_N.
IPR028343. FBPtase.
[Graphical view]
PANTHERiPTHR11556. PTHR11556. 1 hit.
PfamiPF00316. FBPase. 1 hit.
[Graphical view]
PIRSFiPIRSF500210. FBPtase. 1 hit.
PIRSF000904. FBPtase_SBPase. 1 hit.
PRINTSiPR00115. F16BPHPHTASE.

Sequencei

Sequence statusi: Complete.

A1RNR2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQTLAQHLTS QAVNDSLSQL ILTLADTSKA ISHAVRHGAL AGVLGATEQE
60 70 80 90 100
NVQGETQKKL DIITNDMLKD ALKADGTVRG LASEEEDHVV EVSTNGQYLV
110 120 130 140 150
CFDPLDGSSN IDINSLVGTI FSILPASAGE LTETSFLQSG RNQLAAGYVL
160 170 180 190 200
YGPSTMLALT TGQGVQLFTL HPETNEFLLT NAAMSISADT QEFAINMSNQ
210 220 230 240 250
RFWEAPMQTY IADLLLGKIG PREKSFNMRW IAAMVGDVHR VLSRGGIFTY
260 270 280 290 300
PTDNKDPKKP YKLRLMYEAN PMAFLVEQAG GKASTGYETI LDIQPTHIHQ
310 320 330
RVAVILGSAN EVDACLSYHG LDYSEEPGLD
Length:330
Mass (Da):35,823
Last modified:February 6, 2007 - v1
Checksum:i3EBB33DDF8E5D859
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000503 Genomic DNA. Translation: ABM26307.1.
RefSeqiWP_011790743.1. NC_008750.1.

Genome annotation databases

EnsemblBacteriaiABM26307; ABM26307; Sputw3181_3495.
KEGGishw:Sputw3181_3495.
PATRICi23600888. VBISheSp103602_3660.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000503 Genomic DNA. Translation: ABM26307.1.
RefSeqiWP_011790743.1. NC_008750.1.

3D structure databases

ProteinModelPortaliA1RNR2.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABM26307; ABM26307; Sputw3181_3495.
KEGGishw:Sputw3181_3495.
PATRICi23600888. VBISheSp103602_3660.

Phylogenomic databases

HOGENOMiHOG000191264.
KOiK03841.
OMAiYTTRYIG.
OrthoDBiEOG6X10TR.

Enzyme and pathway databases

UniPathwayiUPA00138.
BioCyciSSP351745:GCOY-3600-MONOMER.

Family and domain databases

HAMAPiMF_01855. FBPase_class1.
InterProiIPR000146. FBPase_class-1.
IPR033391. FBPase_N.
IPR028343. FBPtase.
[Graphical view]
PANTHERiPTHR11556. PTHR11556. 1 hit.
PfamiPF00316. FBPase. 1 hit.
[Graphical view]
PIRSFiPIRSF500210. FBPtase. 1 hit.
PIRSF000904. FBPtase_SBPase. 1 hit.
PRINTSiPR00115. F16BPHPHTASE.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: W3-18-1.

Entry informationi

Entry nameiF16PA_SHESW
AccessioniPrimary (citable) accession number: A1RNR2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: February 6, 2007
Last modified: May 11, 2016
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.