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A1RHL0

- TRMB_SHESW

UniProt

A1RHL0 - TRMB_SHESW

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Protein
tRNA (guanine-N(7)-)-methyltransferase
Gene
trmB, Sputw3181_1312
Organism
Shewanella sp. (strain W3-18-1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA By similarity.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei68 – 681S-adenosyl-L-methionine By similarity
Binding sitei93 – 931S-adenosyl-L-methionine By similarity
Binding sitei120 – 1201S-adenosyl-L-methionine By similarity
Active sitei143 – 1431 By similarity
Binding sitei143 – 1431S-adenosyl-L-methionine By similarity
Binding sitei147 – 1471Substrate By similarity
Binding sitei179 – 1791Substrate By similarity

GO - Molecular functioni

  1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    tRNA processing

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Enzyme and pathway databases

    BioCyciSSP351745:GCOY-1355-MONOMER.
    UniPathwayiUPA00989.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    tRNA (guanine-N(7)-)-methyltransferase (EC:2.1.1.33)
    Alternative name(s):
    tRNA (guanine(46)-N(7))-methyltransferase
    tRNA(m7G46)-methyltransferase
    Gene namesi
    Name:trmB
    Ordered Locus Names:Sputw3181_1312
    OrganismiShewanella sp. (strain W3-18-1)
    Taxonomic identifieri351745 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
    ProteomesiUP000002597: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 238238tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation
    PRO_0000288227Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi351745.Sputw3181_1312.

    Structurei

    3D structure databases

    ProteinModelPortaliA1RHL0.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni216 – 2194Substrate binding By similarity

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0220.
    HOGENOMiHOG000073968.
    KOiK03439.
    OMAiHSTLEMA.
    OrthoDBiEOG6K6VBC.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    HAMAPiMF_01057. tRNA_methyltr_TrmB.
    InterProiIPR029063. SAM-dependent_MTases-like.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view]
    PfamiPF02390. Methyltransf_4. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 1 hit.
    TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
    PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A1RHL0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSEVTTAEFN EEGKYLRKIR SFVLREGRLT KGQAQAIESQ WPTMGLDYSP    50
    VPLNLSEVFG READTVLEIG FGMGASLVQM AKDAPEQNFI GIEVHKPGVG 100
    SCLSDAAIAG VTNLRVYHHD AMEVLEHAIA DGSLARVQLF FPDPWHKKRH 150
    HKRRIVQAEF AELVRSKLKI GGVFHMATDW EEYSEHMLEV MNAAPGYKNQ 200
    SVDDTVVPRP DHRPLTKFEA RGHRLGHGVW DLMFERIV 238
    Length:238
    Mass (Da):26,859
    Last modified:February 6, 2007 - v1
    Checksum:i49B2C82E96AA01FA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000503 Genomic DNA. Translation: ABM24155.1.
    RefSeqiWP_011788661.1. NC_008750.1.
    YP_962709.1. NC_008750.1.

    Genome annotation databases

    EnsemblBacteriaiABM24155; ABM24155; Sputw3181_1312.
    GeneIDi4659073.
    KEGGishw:Sputw3181_1312.
    PATRICi23596173. VBISheSp103602_1368.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000503 Genomic DNA. Translation: ABM24155.1 .
    RefSeqi WP_011788661.1. NC_008750.1.
    YP_962709.1. NC_008750.1.

    3D structure databases

    ProteinModelPortali A1RHL0.
    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 351745.Sputw3181_1312.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABM24155 ; ABM24155 ; Sputw3181_1312 .
    GeneIDi 4659073.
    KEGGi shw:Sputw3181_1312.
    PATRICi 23596173. VBISheSp103602_1368.

    Phylogenomic databases

    eggNOGi COG0220.
    HOGENOMi HOG000073968.
    KOi K03439.
    OMAi HSTLEMA.
    OrthoDBi EOG6K6VBC.

    Enzyme and pathway databases

    UniPathwayi UPA00989 .
    BioCyci SSP351745:GCOY-1355-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    HAMAPi MF_01057. tRNA_methyltr_TrmB.
    InterProi IPR029063. SAM-dependent_MTases-like.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view ]
    Pfami PF02390. Methyltransf_4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 1 hit.
    TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
    PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: W3-18-1.

    Entry informationi

    Entry nameiTRMB_SHESW
    AccessioniPrimary (citable) accession number: A1RHL0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 29, 2007
    Last sequence update: February 6, 2007
    Last modified: September 3, 2014
    This is version 49 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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