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Protein

Triosephosphate isomerase

Gene

tpiA

Organism
Shewanella sp. (strain W3-18-1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).UniRule annotation

Catalytic activityi

D-glyceraldehyde 3-phosphate = glycerone phosphate.UniRule annotation

Pathwayi: gluconeogenesis

This protein is involved in the pathway gluconeogenesis, which is part of Carbohydrate biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway gluconeogenesis and in Carbohydrate biosynthesis.

Pathwayi: glycolysis

This protein is involved in step 1 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate from glycerone phosphate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Triosephosphate isomerase (tpiA)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate from glycerone phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei103ElectrophileUniRule annotation1
Active sitei175Proton acceptorUniRule annotation1
Binding sitei181Substrate; via amide nitrogenUniRule annotation1
Binding sitei220SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processGluconeogenesis, Glycolysis, Pentose shunt

Enzyme and pathway databases

UniPathwayiUPA00109; UER00189.
UPA00138.

Names & Taxonomyi

Protein namesi
Recommended name:
Triosephosphate isomeraseUniRule annotation (EC:5.3.1.1UniRule annotation)
Short name:
TIMUniRule annotation
Short name:
TPIUniRule annotation
Alternative name(s):
Triose-phosphate isomeraseUniRule annotation
Gene namesi
Name:tpiAUniRule annotation
Ordered Locus Names:Sputw3181_1066
OrganismiShewanella sp. (strain W3-18-1)
Taxonomic identifieri351745 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003075591 – 260Triosephosphate isomeraseAdd BLAST260

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliA1RGX1.
SMRiA1RGX1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni11 – 13Substrate bindingUniRule annotation3
Regioni241 – 242Substrate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the triosephosphate isomerase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000226413.
KOiK01803.
OMAiIADCFGT.
OrthoDBiPOG091H02GL.

Family and domain databases

CDDicd00311. TIM. 1 hit.
Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00147_B. TIM_B. 1 hit.
InterProiView protein in InterPro
IPR013785. Aldolase_TIM.
IPR035990. TIM_sf.
IPR022896. TrioseP_Isoase_bac/euk.
IPR000652. Triosephosphate_isomerase.
IPR020861. Triosephosphate_isomerase_AS.
PANTHERiPTHR21139. PTHR21139. 1 hit.
PfamiView protein in Pfam
PF00121. TIM. 1 hit.
SUPFAMiSSF51351. SSF51351. 1 hit.
TIGRFAMsiTIGR00419. tim. 1 hit.
PROSITEiView protein in PROSITE
PS00171. TIM_1. 1 hit.
PS51440. TIM_2. 1 hit.

Sequencei

Sequence statusi: Complete.

A1RGX1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALRRPMVAG NWKMNGSAAL AQELFKKFAS KLQNDSAEVV LCPPSIYLES
60 70 80 90 100
VRQLLEANKE ALDGSLVRMG AQNLSQHDFG AYTGEVSGQM LKDSGCRYVI
110 120 130 140 150
IGHSERRRMY GETSNIVAEK FAAAQKHGLT PILCVGESGP AREARRTFEV
160 170 180 190 200
IAEELDIVIQ KNGTMAFDNA IIAYEPLWAV GTGKSATPEQ AQEVHAFIRK
210 220 230 240 250
RLSEVSPFIG ENIRILYGGS VTPSNAADLF AQPDVDGGLI GGASLNSSEF
260
LSLCTIAMSA
Length:260
Mass (Da):28,043
Last modified:February 6, 2007 - v1
Checksum:i6CF066AECCC9CA2C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000503 Genomic DNA. Translation: ABM23916.1.
RefSeqiWP_006082720.1. NC_008750.1.

Genome annotation databases

EnsemblBacteriaiABM23916; ABM23916; Sputw3181_1066.
GeneIDi11773463.
KEGGishw:Sputw3181_1066.

Similar proteinsi

Entry informationi

Entry nameiTPIS_SHESW
AccessioniPrimary (citable) accession number: A1RGX1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: February 6, 2007
Last modified: October 25, 2017
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families