Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

23S rRNA (uracil(747)-C(5))-methyltransferase RlmC

Gene

rlmC

Organism
Shewanella sp. (strain W3-18-1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + uracil(747) in 23S rRNA = S-adenosyl-L-homocysteine + 5-methyluracil(747) in 23S rRNA.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi12Iron-sulfur (4Fe-4S)UniRule annotation1
Metal bindingi20Iron-sulfur (4Fe-4S)UniRule annotation1
Metal bindingi23Iron-sulfur (4Fe-4S)UniRule annotation1
Metal bindingi99Iron-sulfur (4Fe-4S)UniRule annotation1
Binding sitei224S-adenosyl-L-methionineUniRule annotation1
Binding sitei253S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation1
Binding sitei274S-adenosyl-L-methionineUniRule annotation1
Binding sitei321S-adenosyl-L-methionineUniRule annotation1
Active sitei348NucleophileUniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processrRNA processing
Ligand4Fe-4S, Iron, Iron-sulfur, Metal-binding, S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciSSP351745:G1G7O-928-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
23S rRNA (uracil(747)-C(5))-methyltransferase RlmCUniRule annotation (EC:2.1.1.189UniRule annotation)
Alternative name(s):
23S rRNA(m5U747)-methyltransferaseUniRule annotation
Gene namesi
Name:rlmCUniRule annotation
Synonyms:rumB
Ordered Locus Names:Sputw3181_0891
OrganismiShewanella sp. (strain W3-18-1)
Taxonomic identifieri351745 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002820171 – 38923S rRNA (uracil(747)-C(5))-methyltransferase RlmCAdd BLAST389

Proteomic databases

PRIDEiA1RGE6

Structurei

3D structure databases

ProteinModelPortaliA1RGE6
SMRiA1RGE6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. RlmC subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000218547
KOiK03212
OMAiSCQWLEK
OrthoDBiPOG091H00VG

Family and domain databases

HAMAPiMF_01012 23SrRNA_methyltr_RlmC, 1 hit
InterProiView protein in InterPro
IPR001566 23S_rRNA_MeTrfase_RlmD
IPR011825 23SrRNA_MeTrfase_RlmC
IPR030390 MeTrfase_TrmA_AS
IPR030391 MeTrfase_TrmA_CS
IPR029063 SAM-dependent_MTases
IPR010280 U5_MeTrfase_fam
PANTHERiPTHR11061 PTHR11061, 1 hit
PfamiView protein in Pfam
PF05958 tRNA_U5-meth_tr, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit
TIGRFAMsiTIGR02085 meth_trns_rumB, 1 hit
TIGR00479 rumA, 1 hit
PROSITEiView protein in PROSITE
PS51687 SAM_MT_RNA_M5U, 1 hit
PS01230 TRMA_1, 1 hit
PS01231 TRMA_2, 1 hit

Sequencei

Sequence statusi: Complete.

A1RGE6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAVIVNTVE QCGYFNRGQC QSCRHIQVPM AQQLMAKSLE LQQLLKPFVA
60 70 80 90 100
PSAAIFYPPV TGEATAFRNK AKMVVLGAAH APVLGIVSPS GEAVSLCDCL
110 120 130 140 150
LYPSDMQKLL HRLTQFVQQA GIPPYRVDKA KGELKFILLT RSQVRGEYLL
160 170 180 190 200
RFVLRSHNSI ERIERALPTL LAEYPQINVV SVNIQPIHMA ILEGDEEIFL
210 220 230 240 250
TENTRLEERF NDVPLFIRPK SFFQTNPQVA AQLYQTAREW VAEFAPKSLW
260 270 280 290 300
DLFCGVGGFG LHCATKDIAL TGIEIEAEAI SCAQISANLM GLEKVQFMAL
310 320 330 340 350
DSTDFAQGKN AADKPDLIIV NPPRRGIGEA LCQSLSEFAP RAILYSSCNP
360 370 380
KTLAKDLEHI QGYHLTKVQL FDLFPHTDHF EVLAMLVKD
Length:389
Mass (Da):43,299
Last modified:February 6, 2007 - v1
Checksum:i0CC8DA73C741487B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000503 Genomic DNA Translation: ABM23741.1
RefSeqiWP_011788268.1, NC_008750.1

Genome annotation databases

EnsemblBacteriaiABM23741; ABM23741; Sputw3181_0891
KEGGishw:Sputw3181_0891

Similar proteinsi

Entry informationi

Entry nameiRLMC_SHESW
AccessioniPrimary (citable) accession number: A1RGE6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: February 6, 2007
Last modified: May 23, 2018
This is version 60 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health