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A1RFN3

- FTHS_SHESW

UniProt

A1RFN3 - FTHS_SHESW

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Protein
Formate--tetrahydrofolate ligase
Gene
fhs, Sputw3181_0627
Organism
Shewanella sp. (strain W3-18-1)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi65 – 728ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSSP351745:GCOY-643-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligase (EC:6.3.4.3)
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name:
FHS
Short name:
FTHFS
Gene namesi
Name:fhs
Ordered Locus Names:Sputw3181_0627
OrganismiShewanella sp. (strain W3-18-1)
Taxonomic identifieri351745 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
ProteomesiUP000002597: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 570570Formate--tetrahydrofolate ligaseUniRule annotation
PRO_0000300541Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi351745.Sputw3181_0627.

Structurei

3D structure databases

ProteinModelPortaliA1RFN3.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiLKHHGGV.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1RFN3-1 [UniParc]FASTAAdd to Basket

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MLTDMEISSR ASLTNVAELG AELGLLPEEM LLFGSTKAKV DLSVQQRLAG    50
QSRGKLIIVT AVTPTPHGEG KTVTSIGLTQ SLKAIGKKAC ACIRQPSMGP 100
VFGVKGGAAG GGYAQVVPMQ ELNLHLTGDI HAVSSAHNLG AAAIAARLFH 150
ESRLGKVEFE AQSGQAFLDI DPAQIRWHRV LDHNDRCLRQ VQVGLGENNG 200
PVYESGFDIT AASELMAILA LSANLADMRA RIGRLVLALN RQGQVISAED 250
LGVAGAMTAI MVDAIKPTLM QTLNGAPCLI HAGPFANIAH GNSSIIADDI 300
ALKLVDYVIT EGGFGSDMGF EKFCNIKVRQ SGQVPSAAVL VTTLKALKAN 350
SGIESDTDIN TPDEIRLEAG FANLHWHINN VARYGIPVVV AINRFATDTE 400
AELQWLINAV NQTAAFGCEV SDAFSQGEAG AIELAYTVVR AADTQSQFRL 450
LYPDDASLEA KLSTLAEVGY GAAGISLSDE AKQQVREFTS LGYAYLPVCM 500
AKTPLSISHD PMQKGVPKDF IVPIRALVLN AGAGFVTALV GNVMTMPGLG 550
IKPGYLKIDI DEAGEIIGLG 570
Length:570
Mass (Da):60,137
Last modified:February 6, 2007 - v1
Checksum:iC4A5431C9C60FE1C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000503 Genomic DNA. Translation: ABM23478.1.
RefSeqiWP_011788008.1. NC_008750.1.
YP_962032.1. NC_008750.1.

Genome annotation databases

EnsemblBacteriaiABM23478; ABM23478; Sputw3181_0627.
GeneIDi4660169.
KEGGishw:Sputw3181_0627.
PATRICi23594677. VBISheSp103602_0647.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000503 Genomic DNA. Translation: ABM23478.1 .
RefSeqi WP_011788008.1. NC_008750.1.
YP_962032.1. NC_008750.1.

3D structure databases

ProteinModelPortali A1RFN3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 351745.Sputw3181_0627.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABM23478 ; ABM23478 ; Sputw3181_0627 .
GeneIDi 4660169.
KEGGi shw:Sputw3181_0627.
PATRICi 23594677. VBISheSp103602_0647.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi LKHHGGV.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci SSP351745:GCOY-643-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: W3-18-1.

Entry informationi

Entry nameiFTHS_SHESW
AccessioniPrimary (citable) accession number: A1RFN3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: February 6, 2007
Last modified: September 3, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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