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A1RFN3

- FTHS_SHESW

UniProt

A1RFN3 - FTHS_SHESW

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Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Shewanella sp. (strain W3-18-1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi65 – 728ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSSP351745:GCOY-643-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:Sputw3181_0627
OrganismiShewanella sp. (strain W3-18-1)
Taxonomic identifieri351745 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
ProteomesiUP000002597: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 570570Formate--tetrahydrofolate ligasePRO_0000300541Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi351745.Sputw3181_0627.

Structurei

3D structure databases

ProteinModelPortaliA1RFN3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiLKHHGGV.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1RFN3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLTDMEISSR ASLTNVAELG AELGLLPEEM LLFGSTKAKV DLSVQQRLAG
60 70 80 90 100
QSRGKLIIVT AVTPTPHGEG KTVTSIGLTQ SLKAIGKKAC ACIRQPSMGP
110 120 130 140 150
VFGVKGGAAG GGYAQVVPMQ ELNLHLTGDI HAVSSAHNLG AAAIAARLFH
160 170 180 190 200
ESRLGKVEFE AQSGQAFLDI DPAQIRWHRV LDHNDRCLRQ VQVGLGENNG
210 220 230 240 250
PVYESGFDIT AASELMAILA LSANLADMRA RIGRLVLALN RQGQVISAED
260 270 280 290 300
LGVAGAMTAI MVDAIKPTLM QTLNGAPCLI HAGPFANIAH GNSSIIADDI
310 320 330 340 350
ALKLVDYVIT EGGFGSDMGF EKFCNIKVRQ SGQVPSAAVL VTTLKALKAN
360 370 380 390 400
SGIESDTDIN TPDEIRLEAG FANLHWHINN VARYGIPVVV AINRFATDTE
410 420 430 440 450
AELQWLINAV NQTAAFGCEV SDAFSQGEAG AIELAYTVVR AADTQSQFRL
460 470 480 490 500
LYPDDASLEA KLSTLAEVGY GAAGISLSDE AKQQVREFTS LGYAYLPVCM
510 520 530 540 550
AKTPLSISHD PMQKGVPKDF IVPIRALVLN AGAGFVTALV GNVMTMPGLG
560 570
IKPGYLKIDI DEAGEIIGLG
Length:570
Mass (Da):60,137
Last modified:February 6, 2007 - v1
Checksum:iC4A5431C9C60FE1C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000503 Genomic DNA. Translation: ABM23478.1.
RefSeqiWP_011788008.1. NC_008750.1.
YP_962032.1. NC_008750.1.

Genome annotation databases

EnsemblBacteriaiABM23478; ABM23478; Sputw3181_0627.
GeneIDi4660169.
KEGGishw:Sputw3181_0627.
PATRICi23594677. VBISheSp103602_0647.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000503 Genomic DNA. Translation: ABM23478.1 .
RefSeqi WP_011788008.1. NC_008750.1.
YP_962032.1. NC_008750.1.

3D structure databases

ProteinModelPortali A1RFN3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 351745.Sputw3181_0627.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABM23478 ; ABM23478 ; Sputw3181_0627 .
GeneIDi 4660169.
KEGGi shw:Sputw3181_0627.
PATRICi 23594677. VBISheSp103602_0647.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi LKHHGGV.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci SSP351745:GCOY-643-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: W3-18-1.

Entry informationi

Entry nameiFTHS_SHESW
AccessioniPrimary (citable) accession number: A1RFN3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: February 6, 2007
Last modified: October 1, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3