Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

A1RFN3

- FTHS_SHESW

UniProt

A1RFN3 - FTHS_SHESW

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Shewanella sp. (strain W3-18-1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 45 (01 Oct 2014)
      Sequence version 1 (06 Feb 2007)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi65 – 728ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSSP351745:GCOY-643-MONOMER.
    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetaseUniRule annotation
    Short name:
    FHSUniRule annotation
    Short name:
    FTHFSUniRule annotation
    Gene namesi
    Name:fhsUniRule annotation
    Ordered Locus Names:Sputw3181_0627
    OrganismiShewanella sp. (strain W3-18-1)
    Taxonomic identifieri351745 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
    ProteomesiUP000002597: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 570570Formate--tetrahydrofolate ligasePRO_0000300541Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi351745.Sputw3181_0627.

    Structurei

    3D structure databases

    ProteinModelPortaliA1RFN3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    HOGENOMiHOG000040280.
    KOiK01938.
    OMAiLKHHGGV.
    OrthoDBiEOG6PCPSP.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00721. FTHFS_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A1RFN3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLTDMEISSR ASLTNVAELG AELGLLPEEM LLFGSTKAKV DLSVQQRLAG    50
    QSRGKLIIVT AVTPTPHGEG KTVTSIGLTQ SLKAIGKKAC ACIRQPSMGP 100
    VFGVKGGAAG GGYAQVVPMQ ELNLHLTGDI HAVSSAHNLG AAAIAARLFH 150
    ESRLGKVEFE AQSGQAFLDI DPAQIRWHRV LDHNDRCLRQ VQVGLGENNG 200
    PVYESGFDIT AASELMAILA LSANLADMRA RIGRLVLALN RQGQVISAED 250
    LGVAGAMTAI MVDAIKPTLM QTLNGAPCLI HAGPFANIAH GNSSIIADDI 300
    ALKLVDYVIT EGGFGSDMGF EKFCNIKVRQ SGQVPSAAVL VTTLKALKAN 350
    SGIESDTDIN TPDEIRLEAG FANLHWHINN VARYGIPVVV AINRFATDTE 400
    AELQWLINAV NQTAAFGCEV SDAFSQGEAG AIELAYTVVR AADTQSQFRL 450
    LYPDDASLEA KLSTLAEVGY GAAGISLSDE AKQQVREFTS LGYAYLPVCM 500
    AKTPLSISHD PMQKGVPKDF IVPIRALVLN AGAGFVTALV GNVMTMPGLG 550
    IKPGYLKIDI DEAGEIIGLG 570
    Length:570
    Mass (Da):60,137
    Last modified:February 6, 2007 - v1
    Checksum:iC4A5431C9C60FE1C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000503 Genomic DNA. Translation: ABM23478.1.
    RefSeqiWP_011788008.1. NC_008750.1.
    YP_962032.1. NC_008750.1.

    Genome annotation databases

    EnsemblBacteriaiABM23478; ABM23478; Sputw3181_0627.
    GeneIDi4660169.
    KEGGishw:Sputw3181_0627.
    PATRICi23594677. VBISheSp103602_0647.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000503 Genomic DNA. Translation: ABM23478.1 .
    RefSeqi WP_011788008.1. NC_008750.1.
    YP_962032.1. NC_008750.1.

    3D structure databases

    ProteinModelPortali A1RFN3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 351745.Sputw3181_0627.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABM23478 ; ABM23478 ; Sputw3181_0627 .
    GeneIDi 4660169.
    KEGGi shw:Sputw3181_0627.
    PATRICi 23594677. VBISheSp103602_0647.

    Phylogenomic databases

    eggNOGi COG2759.
    HOGENOMi HOG000040280.
    KOi K01938.
    OMAi LKHHGGV.
    OrthoDBi EOG6PCPSP.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .
    BioCyci SSP351745:GCOY-643-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00721. FTHFS_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: W3-18-1.

    Entry informationi

    Entry nameiFTHS_SHESW
    AccessioniPrimary (citable) accession number: A1RFN3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 11, 2007
    Last sequence update: February 6, 2007
    Last modified: October 1, 2014
    This is version 45 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3