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Protein

Large-conductance mechanosensitive channel

Gene

mscL

Organism
Shewanella sp. (strain W3-18-1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channel
Biological processIon transport, Transport

Enzyme and pathway databases

BioCyciSSP351745:G1G7O-633-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Large-conductance mechanosensitive channelUniRule annotation
Gene namesi
Name:mscLUniRule annotation
Ordered Locus Names:Sputw3181_0602
OrganismiShewanella sp. (strain W3-18-1)
Taxonomic identifieri351745 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei9 – 29HelicalUniRule annotationAdd BLAST21
Transmembranei79 – 99HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000154291 – 136Large-conductance mechanosensitive channelAdd BLAST136

Interactioni

Subunit structurei

Homopentamer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliA1RFK8
SMRiA1RFK8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MscL family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000226782
KOiK03282
OMAiYGSFIQT
OrthoDBiPOG091H07L6

Family and domain databases

Gene3Di1.10.1200.120, 1 hit
HAMAPiMF_00115 MscL, 1 hit
InterProiView protein in InterPro
IPR036019 Gated_MS_channel
IPR019823 Mechanosensitive_channel_CS
IPR001185 MS_channel
IPR037673 MSC/AndL
PANTHERiPTHR30266 PTHR30266, 1 hit
PfamiView protein in Pfam
PF01741 MscL, 1 hit
PRINTSiPR01264 MECHCHANNEL
SUPFAMiSSF81330 SSF81330, 1 hit
TIGRFAMsiTIGR00220 mscL, 1 hit
PROSITEiView protein in PROSITE
PS01327 MSCL, 1 hit

Sequencei

Sequence statusi: Complete.

A1RFK8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLIKEFKAF ASRGNVIDMA VGIIIGAAFG KIVSSFVADV IMPPIGIILG
60 70 80 90 100
GVNFSDLSIV LQAAQGDAPS VVIAYGKFIQ TVIDFTIIAF AIFMGLKAIN
110 120 130
TLKRKEEEAP KAPPTPTKEE ELLSEIRDLL KAQQEK
Length:136
Mass (Da):14,607
Last modified:February 6, 2007 - v1
Checksum:iBC5821992F760CD6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000503 Genomic DNA Translation: ABM23453.1
RefSeqiWP_011787984.1, NC_008750.1

Genome annotation databases

EnsemblBacteriaiABM23453; ABM23453; Sputw3181_0602
KEGGishw:Sputw3181_0602

Similar proteinsi

Entry informationi

Entry nameiMSCL_SHESW
AccessioniPrimary (citable) accession number: A1RFK8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 6, 2007
Last modified: April 25, 2018
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health