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Protein

Large-conductance mechanosensitive channel

Gene

mscL

Organism
Shewanella sp. (strain W3-18-1)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.UniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Ion channel

Keywords - Biological processi

Ion transport, Transport

Enzyme and pathway databases

BioCyciSSP351745:GCOY-618-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Large-conductance mechanosensitive channelUniRule annotation
Gene namesi
Name:mscLUniRule annotation
Ordered Locus Names:Sputw3181_0602
OrganismiShewanella sp. (strain W3-18-1)
Taxonomic identifieri351745 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei32 – 5221HelicalUniRule annotationAdd
BLAST
Transmembranei79 – 9921HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 136136Large-conductance mechanosensitive channelPRO_1000015429Add
BLAST

Interactioni

Subunit structurei

Homopentamer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliA1RFK8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MscL family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000226782.
KOiK03282.
OMAiTEFKEFA.
OrthoDBiPOG091H07L6.

Family and domain databases

HAMAPiMF_00115. MscL. 1 hit.
InterProiIPR019823. Mechanosensitive_channel_CS.
IPR001185. MS_channel.
[Graphical view]
PfamiPF01741. MscL. 1 hit.
[Graphical view]
PRINTSiPR01264. MECHCHANNEL.
SUPFAMiSSF81330. SSF81330. 1 hit.
TIGRFAMsiTIGR00220. mscL. 1 hit.
PROSITEiPS01327. MSCL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1RFK8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLIKEFKAF ASRGNVIDMA VGIIIGAAFG KIVSSFVADV IMPPIGIILG
60 70 80 90 100
GVNFSDLSIV LQAAQGDAPS VVIAYGKFIQ TVIDFTIIAF AIFMGLKAIN
110 120 130
TLKRKEEEAP KAPPTPTKEE ELLSEIRDLL KAQQEK
Length:136
Mass (Da):14,607
Last modified:February 6, 2007 - v1
Checksum:iBC5821992F760CD6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000503 Genomic DNA. Translation: ABM23453.1.
RefSeqiWP_011787984.1. NC_008750.1.

Genome annotation databases

EnsemblBacteriaiABM23453; ABM23453; Sputw3181_0602.
KEGGishw:Sputw3181_0602.
PATRICi23594627. VBISheSp103602_0622.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000503 Genomic DNA. Translation: ABM23453.1.
RefSeqiWP_011787984.1. NC_008750.1.

3D structure databases

ProteinModelPortaliA1RFK8.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABM23453; ABM23453; Sputw3181_0602.
KEGGishw:Sputw3181_0602.
PATRICi23594627. VBISheSp103602_0622.

Phylogenomic databases

HOGENOMiHOG000226782.
KOiK03282.
OMAiTEFKEFA.
OrthoDBiPOG091H07L6.

Enzyme and pathway databases

BioCyciSSP351745:GCOY-618-MONOMER.

Family and domain databases

HAMAPiMF_00115. MscL. 1 hit.
InterProiIPR019823. Mechanosensitive_channel_CS.
IPR001185. MS_channel.
[Graphical view]
PfamiPF01741. MscL. 1 hit.
[Graphical view]
PRINTSiPR01264. MECHCHANNEL.
SUPFAMiSSF81330. SSF81330. 1 hit.
TIGRFAMsiTIGR00220. mscL. 1 hit.
PROSITEiPS01327. MSCL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMSCL_SHESW
AccessioniPrimary (citable) accession number: A1RFK8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 6, 2007
Last modified: September 7, 2016
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.