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Protein

Glycerol-3-phosphate acyltransferase

Gene

plsB

Organism
Shewanella sp. (strain W3-18-1)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Acyl-CoA + sn-glycerol 3-phosphate = CoA + 1-acyl-sn-glycerol 3-phosphate.UniRule annotation

Pathwayi: CDP-diacylglycerol biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes CDP-diacylglycerol from sn-glycerol 3-phosphate.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Glycerol-3-phosphate acyltransferase (plsB)
  2. no protein annotated in this organism
  3. no protein annotated in this organism
This subpathway is part of the pathway CDP-diacylglycerol biosynthesis, which is itself part of Phospholipid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CDP-diacylglycerol from sn-glycerol 3-phosphate, the pathway CDP-diacylglycerol biosynthesis and in Phospholipid metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processLipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Enzyme and pathway databases

UniPathwayiUPA00557; UER00612.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycerol-3-phosphate acyltransferaseUniRule annotation (EC:2.3.1.15UniRule annotation)
Short name:
GPATUniRule annotation
Gene namesi
Name:plsBUniRule annotation
Ordered Locus Names:Sputw3181_0136
OrganismiShewanella sp. (strain W3-18-1)
Taxonomic identifieri351745 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella

Subcellular locationi

  • Cell inner membrane UniRule annotation; Peripheral membrane protein UniRule annotation; Cytoplasmic side UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000494631 – 807Glycerol-3-phosphate acyltransferaseAdd BLAST807

Structurei

3D structure databases

ProteinModelPortaliA1RE94.
SMRiA1RE94.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi308 – 313HXXXXD motif6

Domaini

The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.UniRule annotation

Sequence similaritiesi

Belongs to the GPAT/DAPAT family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000218231.
KOiK00631.
OMAiEVIYVPC.
OrthoDBiPOG091H06BX.

Family and domain databases

HAMAPiMF_00393. Glyc3P_acyltrans. 1 hit.
InterProiView protein in InterPro
IPR022284. GPAT/DHAPAT.
IPR028354. GPAT_PlsB.
IPR002123. Plipid/glycerol_acylTrfase.
PANTHERiPTHR12563. PTHR12563. 1 hit.
PfamiView protein in Pfam
PF01553. Acyltransferase. 1 hit.
PIRSFiPIRSF500064. GPAT. 1 hit.
PIRSF000437. GPAT_DHAPAT. 1 hit.
SMARTiView protein in SMART
SM00563. PlsC. 1 hit.
TIGRFAMsiTIGR03703. plsB. 1 hit.

Sequencei

Sequence statusi: Complete.

A1RE94-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPKQDSLWLK SLRWIQKHLV HTIVVPQDPF ADLNLDTSRP LAYVMKTESL
60 70 80 90 100
SDIAALSEVT EKLGLPSPYE PLVVNGVVAP RVVCLQGRKP LFGERAGNEP
110 120 130 140 150
FLECFMRLLA VHKERPELDI QLVPVSLYWG RTPGKEDDTM KAAVLERENP
160 170 180 190 200
TWLRKCFMIL FLGRHNFVQF SNAVSLRYMA DEHGTDMGIA HKLARVARVH
210 220 230 240 250
FRRQRKVMTG PLLPNRQALF DSLLKSESLR KAIQEEAVSK KISETQSRET
260 270 280 290 300
AIEYLDEIAA NYSDSLVRIA ERFLTWLWNK LYSGINIKGA EHIRQLHHDG
310 320 330 340 350
HEIVYVPCHR SHMDYLLLSY ILYYQGMVPP HIAAGINLNF WPAGPLFRRG
360 370 380 390 400
GAFFIRRSFN GNKLYTAVFR EYLDQLFAKG YSVEYFSEGG RSRTGRLLAP
410 420 430 440 450
KTGMIAMTMN SVLRGIERPV TLVPVYLGYD HVMEVATYHK ELSGKKKQKE
460 470 480 490 500
SVWQVFGAIR KLGNFGQGYV NFGEPITLQT FLNEMAPNWR AELADDPEQK
510 520 530 540 550
PTWLTPAVNV LANRVMTRIN DAAAASSVTL TSLALLASEQ NALERCLLER
560 570 580 590 600
QLDLYLTLLK RVPYTSFTSV AEGDGKHLVQ QGIDLNKFSV SSDPLGEIVS
610 620 630 640 650
IDANQAISMT YYRNNIIHLF IIPSLIASCL THNEQSQRQQ IVAIVNDFYP
660 670 680 690 700
LLKAELFMGI KDIPSYVNQV LDLFIEQGLI TESDNLSVVT EHSSQLVLLS
710 720 730 740 750
GSVSETLQRY AIIFNLLAHR PKMERSELES ESHLLAQRLG ALHGITAPEF
760 770 780 790 800
YDKKLYGTLS VKLKELGYLS DKDDKSDVKR IRDQANSLLR ASVRQTIVAS

VTAEHIS
Length:807
Mass (Da):91,375
Last modified:February 6, 2007 - v1
Checksum:iB2329DB2B660F8C1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000503 Genomic DNA. Translation: ABM22989.1.
RefSeqiWP_011787556.1. NC_008750.1.

Genome annotation databases

EnsemblBacteriaiABM22989; ABM22989; Sputw3181_0136.
KEGGishw:Sputw3181_0136.

Similar proteinsi

Entry informationi

Entry nameiPLSB_SHESW
AccessioniPrimary (citable) accession number: A1RE94
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 6, 2007
Last modified: August 30, 2017
This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families