Reviewed, UniProtKB/Swiss-Prot A1RBC4 (MTLD_ARTAT)

Names and origin

Protein names

Recommended name:
    Mannitol-1-phosphate 5-dehydrogenase
    EC=1.1.1.17

Gene names

Name:	mtlD
Ordered Locus Names:	AAur_3858

Organism

Arthrobacter aurescens (strain TC1) [Complete proteome] [HAMAP]

Taxonomic identifier

290340 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micrococcineae › Micrococcaceae › Arthrobacter

Protein attributes

Sequence length	382 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	D-mannitol 1-phosphate + NAD+ = D-fructose 6-phosphate + NADH. HAMAP MF_00196
Sequence similarities	Belongs to the mannitol dehydrogenase family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	coenzyme binding Inferred from electronic annotation. Source: InterPro mannitol-1-phosphate 5-dehydrogenase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 382	382	Mannitol-1-phosphate 5-dehydrogenase HAMAP MF_00196		PRO_1000011792
Regions
	Nucleotide binding	3 – 14	12	NAD By similarity

Sequences

	Sequence		Length	Mass (Da)
	A1RBC4-1 [UniParc]. Last modified February 6, 2007. Version 1. Checksum: 4F916BE9A989995B	FASTA	382	40,753
	10 20 30 40 50 60 MKAVHFGAGN IGRGFVGLLL HEAGYEVVFA DVADALISQL ASASSYDVHE VGENPAVKTV 70 80 90 100 110 120 SGFRAFNSAS QEAAVVEEIS TADVLTTAVG PHILKFVAPV IARGLAVRPA DLPPLQVMAC 130 140 150 160 170 180 ENAINATDLL HTEIRAAWDD SAGDLDAVAV FANTAVDRIV PNQAPGQGLD VTVETFYEWV 190 200 210 220 230 240 IDRTPFGGNA PKIPGATFVD ELGPYIERKL FTVNTGHASA AYFGYAAGLE KISDAMADPA 250 260 270 280 290 300 VAAKVRAVLE ETKELLVAKH GFEEAEQEAY VQKILSRFTN PHLPDTVNRV GRAPLRKLSR 310 320 330 340 350 360 HERFVGPAAE LAERGVTPAA LLEAMSAALR FDDGNDDEAV ELTNLLSELD AAAAVERITE 370 380 LTPTHPLFPA LQKLVEDRQA EA

References

[1]

"Secrets of soil survival revealed by the genome sequence of Arthrobacter aurescens TC1." Mongodin E.F., Shapir N., Daugherty S.C., DeBoy R.T., Emerson J.B., Shvartzbeyn A., Radune D., Vamathevan J., Riggs F., Grinberg V., Khouri H.M., Wackett L.P., Nelson K.E., Sadowsky M.J. PLoS Genet. 2:2094-2106(2006) [PubMed: 17194220] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000474 Genomic DNA. Translation: ABM09759.1.
RefSeq	YP_949536.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	4639719.
GenomeReviews	Gene locus AAur_3858 in contig CP000474_GR.
KEGG	aau:AAur_3858.
TIGR	AAur_3858.
Phylogenomic databases
OMA	A1RBC4. VDRIVPN.
Family and domain databases
HAMAP	MF_00196. [Tree]
InterPro	IPR013328. DH_multihelical. IPR013118. Mannitol_DH_C. IPR000669. Mannitol_DH_core. IPR013131. Mannitol_DH_N. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. G3DSA:1.10.1040.10. Opine_DH. 1 hit.
Pfam	PF01232. Mannitol_dh. 1 hit. PF08125. Mannitol_dh_C. 1 hit. [Graphical view]
PRINTS	PR00084. MTLDHDRGNASE.
PROSITE	PS00974. MANNITOL_DHGENASE. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MTLD_ARTAT

Accession

Primary (citable) accession number: A1RBC4

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	February 6, 2007
Last modified:	June 16, 2009
This is version 20 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)