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A1RAI8

- TRMB_ARTAT

UniProt

A1RAI8 - TRMB_ARTAT

Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene

trmB

Organism
Arthrobacter aurescens (strain TC1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 51 (01 Oct 2014)
      Sequence version 1 (06 Feb 2007)
      Previous versions | rss
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    • Comment

    Functioni

    Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.UniRule annotation

    Catalytic activityi

    S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei85 – 851S-adenosyl-L-methionineUniRule annotation
    Binding sitei110 – 1101S-adenosyl-L-methionineUniRule annotation
    Binding sitei137 – 1371S-adenosyl-L-methionineUniRule annotation
    Active sitei160 – 1601By similarity
    Binding sitei160 – 1601S-adenosyl-L-methionineUniRule annotation
    Binding sitei164 – 1641SubstrateUniRule annotation
    Binding sitei196 – 1961SubstrateUniRule annotation

    GO - Molecular functioni

    1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    tRNA processing

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Enzyme and pathway databases

    BioCyciAAUR290340:GI59-3556-MONOMER.
    UniPathwayiUPA00989.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation (EC:2.1.1.33UniRule annotation)
    Alternative name(s):
    tRNA (guanine(46)-N(7))-methyltransferaseUniRule annotation
    tRNA(m7G46)-methyltransferaseUniRule annotation
    Gene namesi
    Name:trmBUniRule annotation
    Ordered Locus Names:AAur_3557
    OrganismiArthrobacter aurescens (strain TC1)
    Taxonomic identifieri290340 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeMicrococcaceaeArthrobacter
    ProteomesiUP000000637: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 301301tRNA (guanine-N(7)-)-methyltransferasePRO_0000288118Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi290340.AAur_3557.

    Structurei

    3D structure databases

    ProteinModelPortaliA1RAI8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni280 – 2834Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0220.
    HOGENOMiHOG000073968.
    KOiK03439.
    OMAiGWAPRFE.
    OrthoDBiEOG6K6VBC.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    HAMAPiMF_01057. tRNA_methyltr_TrmB.
    InterProiIPR029063. SAM-dependent_MTases-like.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view]
    PfamiPF02390. Methyltransf_4. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 1 hit.
    TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
    PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A1RAI8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSETPDSPRP VTPGSQASFG TYGGRPVSFV RRGTRLQGRR QAAWEEHAER    50
    WAIQVPRHVA NTSVHPDYTF DAEAVFGRKA PLIVEIGSGL GDAVVHAAEQ 100
    NPDKDFLAVE VYTPGLANTI IKINSRGLTN VRVVEANAPE VLESMLPEGS 150
    VSELWVFFPD PWHKARHHKR RLIQPAFASV AAKALVKGGY WRIATDWSNY 200
    AVHVREVLTG STEFENMHEG ERSGEESPLT QVWQSGVESV VGGAPVREGR 250
    APVSTEHTGP NEGVDEEGGW APRFDGRIRT SFENKAHEAG RMIFDLTYRK 300
    R 301
    Length:301
    Mass (Da):33,299
    Last modified:February 6, 2007 - v1
    Checksum:i7665727B93B13679
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000474 Genomic DNA. Translation: ABM06497.1.
    RefSeqiYP_949250.1. NC_008711.1.

    Genome annotation databases

    EnsemblBacteriaiABM06497; ABM06497; AAur_3557.
    GeneIDi4639067.
    KEGGiaau:AAur_3557.
    PATRICi20982652. VBIArtAur67810_3629.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000474 Genomic DNA. Translation: ABM06497.1 .
    RefSeqi YP_949250.1. NC_008711.1.

    3D structure databases

    ProteinModelPortali A1RAI8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 290340.AAur_3557.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABM06497 ; ABM06497 ; AAur_3557 .
    GeneIDi 4639067.
    KEGGi aau:AAur_3557.
    PATRICi 20982652. VBIArtAur67810_3629.

    Phylogenomic databases

    eggNOGi COG0220.
    HOGENOMi HOG000073968.
    KOi K03439.
    OMAi GWAPRFE.
    OrthoDBi EOG6K6VBC.

    Enzyme and pathway databases

    UniPathwayi UPA00989 .
    BioCyci AAUR290340:GI59-3556-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    HAMAPi MF_01057. tRNA_methyltr_TrmB.
    InterProi IPR029063. SAM-dependent_MTases-like.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view ]
    Pfami PF02390. Methyltransf_4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 1 hit.
    TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
    PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: TC1.

    Entry informationi

    Entry nameiTRMB_ARTAT
    AccessioniPrimary (citable) accession number: A1RAI8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 29, 2007
    Last sequence update: February 6, 2007
    Last modified: October 1, 2014
    This is version 51 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3