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A1RAI8

- TRMB_ARTAT

UniProt

A1RAI8 - TRMB_ARTAT

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Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene
trmB, AAur_3557
Organism
Arthrobacter aurescens (strain TC1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA By similarity.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei85 – 851S-adenosyl-L-methionine By similarity
Binding sitei110 – 1101S-adenosyl-L-methionine By similarity
Binding sitei137 – 1371S-adenosyl-L-methionine By similarity
Active sitei160 – 1601 By similarity
Binding sitei160 – 1601S-adenosyl-L-methionine By similarity
Binding sitei164 – 1641Substrate By similarity
Binding sitei196 – 1961Substrate By similarity

GO - Molecular functioni

  1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciAAUR290340:GI59-3556-MONOMER.
UniPathwayiUPA00989.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferase (EC:2.1.1.33)
Alternative name(s):
tRNA (guanine(46)-N(7))-methyltransferase
tRNA(m7G46)-methyltransferase
Gene namesi
Name:trmB
Ordered Locus Names:AAur_3557
OrganismiArthrobacter aurescens (strain TC1)
Taxonomic identifieri290340 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeMicrococcaceaeArthrobacter
ProteomesiUP000000637: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 301301tRNA (guanine-N(7)-)-methyltransferaseUniRule annotationPRO_0000288118Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi290340.AAur_3557.

Structurei

3D structure databases

ProteinModelPortaliA1RAI8.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni280 – 2834Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0220.
HOGENOMiHOG000073968.
KOiK03439.
OMAiGWAPRFE.
OrthoDBiEOG6K6VBC.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01057. tRNA_methyltr_TrmB.
InterProiIPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view]
PfamiPF02390. Methyltransf_4. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1RAI8-1 [UniParc]FASTAAdd to Basket

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MSETPDSPRP VTPGSQASFG TYGGRPVSFV RRGTRLQGRR QAAWEEHAER    50
WAIQVPRHVA NTSVHPDYTF DAEAVFGRKA PLIVEIGSGL GDAVVHAAEQ 100
NPDKDFLAVE VYTPGLANTI IKINSRGLTN VRVVEANAPE VLESMLPEGS 150
VSELWVFFPD PWHKARHHKR RLIQPAFASV AAKALVKGGY WRIATDWSNY 200
AVHVREVLTG STEFENMHEG ERSGEESPLT QVWQSGVESV VGGAPVREGR 250
APVSTEHTGP NEGVDEEGGW APRFDGRIRT SFENKAHEAG RMIFDLTYRK 300
R 301
Length:301
Mass (Da):33,299
Last modified:February 6, 2007 - v1
Checksum:i7665727B93B13679
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000474 Genomic DNA. Translation: ABM06497.1.
RefSeqiYP_949250.1. NC_008711.1.

Genome annotation databases

EnsemblBacteriaiABM06497; ABM06497; AAur_3557.
GeneIDi4639067.
KEGGiaau:AAur_3557.
PATRICi20982652. VBIArtAur67810_3629.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000474 Genomic DNA. Translation: ABM06497.1 .
RefSeqi YP_949250.1. NC_008711.1.

3D structure databases

ProteinModelPortali A1RAI8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 290340.AAur_3557.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABM06497 ; ABM06497 ; AAur_3557 .
GeneIDi 4639067.
KEGGi aau:AAur_3557.
PATRICi 20982652. VBIArtAur67810_3629.

Phylogenomic databases

eggNOGi COG0220.
HOGENOMi HOG000073968.
KOi K03439.
OMAi GWAPRFE.
OrthoDBi EOG6K6VBC.

Enzyme and pathway databases

UniPathwayi UPA00989 .
BioCyci AAUR290340:GI59-3556-MONOMER.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
HAMAPi MF_01057. tRNA_methyltr_TrmB.
InterProi IPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view ]
Pfami PF02390. Methyltransf_4. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TC1.

Entry informationi

Entry nameiTRMB_ARTAT
AccessioniPrimary (citable) accession number: A1RAI8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: February 6, 2007
Last modified: June 11, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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