A1RA16 (A1RA16_ARTAT) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Phosphoribosylaminoimidazole-succinocarboxamide synthase HAMAP MF_00137
EC=6.3.2.6 HAMAP MF_00137

Alternative name(s):
SAICAR synthetase HAMAP MF_00137

Gene names

Name:	purC HAMAP MF_00137
Ordered Locus Names:	AAur_3383

Organism

Arthrobacter aurescens (strain TC1) [Complete proteome] [HAMAP] EMBL ABM08272.1

Taxonomic identifier

290340 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micrococcineae › Micrococcaceae › Arthrobacter

Protein attributes

Sequence length	312 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate = ADP + phosphate + (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate. HAMAP MF_00137
Pathway	Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2. HAMAP MF_00137
Sequence similarities	Belongs to the SAICAR synthetase family. HAMAP MF_00137

Ontologies

Keywords
Biological process	Purine biosynthesis HAMAP MF_00137
Ligand	ATP-binding HAMAP MF_00137 Nucleotide-binding
Molecular function	Ligase HAMAP MF_00137 EMBL ABM08272.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	purine nucleotide biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoribosylaminoimidazolesuccinocarboxamide synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A1RA16 [UniParc]. Last modified February 6, 2007. Version 1. Checksum: 46D96F9842BF2D87	FASTA	312	34,336
	10 20 30 40 50 60 MTEGIPTGGF ETETLELPGW KHVYSGKVRD LYVPADEAIT EKIGQECVLV VASDRISAYD 70 80 90 100 110 120 HVLSSEIPDK GRVLTQLSLW WFDQLDVEHH VLASTVEGGV PEAVEGRAMI CKKLDMFPVE 130 140 150 160 170 180 CIARGYLTGS GLAEYKESRT VCNIPLPEGL VDGSRLEKAL FTPSAKAEVG EHDVNITYDD 190 200 210 220 230 240 VVAMVGDDIA ARLSELTLKI YTRAEEIARE RGIILADTKV EFGIDAATGV ITLGDEVLTP 250 260 270 280 290 300 DSSRFWDAST YAPGKSQPSY DKQYVRDWLT SAESGWDKSS DTPPPPLPAE VVERTRARYV 310 EAYEKLTGRT FA

References

[1]

"Secrets of soil survival revealed by the genome sequence of Arthrobacter aurescens TC1." Mongodin E.F., Shapir N., Daugherty S.C., DeBoy R.T., Emerson J.B., Shvartzbeyn A., Radune D., Vamathevan J., Riggs F., Grinberg V., Khouri H.M., Wackett L.P., Nelson K.E., Sadowsky M.J. PLoS Genet. 2:2094-2106(2006) [PubMed: 17194220] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000474 Genomic DNA. Translation: ABM08272.1.
RefSeq	YP_949078.1. NC_008711.1.
3D structure databases
ProteinModelPortal	A1RA16.
ModBase	Search...
Protein-protein interaction databases
STRING	A1RA16.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4637471.
GenomeReviews	Gene locus AAur_3383 in contig CP000474_GR.
KEGG	aau:AAur_3383.
PATRIC	20982286. VBIArtAur67810_3446.
TIGR	AAur_3383.
Phylogenomic databases
eggNOG	COG0152.
HOGENOM	HBG555040.
OMA	LTLMDEV.
ProtClustDB	CLSK960249.
Family and domain databases
HAMAP	MF_00137. SAICAR_synth. [Tree]
InterPro	IPR013816. ATP_grasp_subdomain_2. IPR001636. SAICAR_synth. IPR018236. SAICAR_synthetase_CS. [Graphical view]
Gene3D	G3DSA:3.30.470.20. ATP_grasp_subdomain_2. 1 hit.
KO	K01923.
PANTHER	PTHR11609. SAICAR_synt. 1 hit.
Pfam	PF01259. SAICAR_synt. 1 hit. [Graphical view]
TIGRFAMs	TIGR00081. PurC. 1 hit.
PROSITE	PS01057. SAICAR_SYNTHETASE_1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

A1RA16_ARTAT

Accession

Primary (citable) accession number: A1RA16

Entry history

Integrated into UniProtKB/TrEMBL:	February 6, 2007
Last sequence update:	February 6, 2007
Last modified:	December 14, 2011
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)