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A1R958

- A1R958_ARTAT

UniProt

A1R958 - A1R958_ARTAT

Protein
Submitted name:

4-aminobutyrate transaminase

Gene

gabT

Organism
Arthrobacter aurescens (strain TC1)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 54 (01 Oct 2014)
      Sequence version 1 (06 Feb 2007)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei295 – 2951N6-(pyridoxalphosphate)lysine (covalent)Imported

    GO - Molecular functioni

    1. 4-aminobutyrate transaminase activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. gamma-aminobutyric acid metabolic process Source: InterPro

    Keywords - Molecular functioni

    AminotransferaseImported, Transferase

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotation

    Enzyme and pathway databases

    BioCyciAAUR290340:GI59-3068-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    4-aminobutyrate transaminaseImported (EC:2.6.1.19Imported)
    Gene namesi
    Name:gabTImported
    Ordered Locus Names:AAur_3069Imported
    OrganismiArthrobacter aurescens (strain TC1)Imported
    Taxonomic identifieri290340 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeMicrococcaceaeArthrobacter
    ProteomesiUP000000637: Chromosome

    Interactioni

    Protein-protein interaction databases

    STRINGi290340.AAur_3069.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4ATPX-ray2.80A/B/C/D/E/F/G/H/I/J/K/L1-456[»]
    4ATQX-ray2.75A/B/C/D/E/F/G/H/I/J/K/L1-456[»]
    ProteinModelPortaliA1R958.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0160.
    HOGENOMiHOG000020206.
    KOiK07250.
    OMAiNSFTHTA.
    OrthoDBiEOG6QVRHN.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    InterProiIPR004632. 4NH2But_aminotransferase_bac.
    IPR005814. Aminotrans_3.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PANTHERiPTHR11986. PTHR11986. 1 hit.
    PfamiPF00202. Aminotran_3. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
    SUPFAMiSSF53383. SSF53383. 1 hit.
    TIGRFAMsiTIGR00700. GABAtrnsam. 1 hit.
    PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A1R958-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTTTANELSY RIEQKRNING AFPGPKSQAL AERRSAVVAA GVASGVPVYV    50
    EDADGGIIRD VDGNSFIDLG SGIAVTSVGA SDPAVVAAVQ EAAAHFTHTC 100
    FMVTPYEGYV AVAEQLNRLT PGDHAKRTVL FNSGAEAVEN AVKVARLATG 150
    RDAVVAFDHA YHGRTNLTMA LTAKAMPYKT NFGPFAPEVY RMPMSYPFRE 200
    ENPEITGAEA AKRAITMIEK QIGGDQVAAI IIEPIQGEGG FIVPAEGFLP 250
    ALSEWAKEKG IVFIADEVQS GFCRTGEWFA VDHEGVVPDI ITMAKGIAGG 300
    LPLSAITGRA DLLDAVHPGG LGGTYGGNPV ACAAALAAID TMEQHDLNGR 350
    ARHIEELALG KLRELAAELS AGGGSVVGDI RGRGAMLAIE LVQPGSKEPN 400
    AELTKAVAAA CLKEGVIILT CGTYGNVIRL LPPLVISDEL LIDGLEVLAA 450
    AIKAHA 456
    Length:456
    Mass (Da):47,557
    Last modified:February 6, 2007 - v1
    Checksum:i7318C673C41B1ECB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000474 Genomic DNA. Translation: ABM08874.1.
    RefSeqiYP_948770.1. NC_008711.1.

    Genome annotation databases

    EnsemblBacteriaiABM08874; ABM08874; AAur_3069.
    GeneIDi4640834.
    KEGGiaau:AAur_3069.
    PATRICi20981634. VBIArtAur67810_3121.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000474 Genomic DNA. Translation: ABM08874.1 .
    RefSeqi YP_948770.1. NC_008711.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4ATP X-ray 2.80 A/B/C/D/E/F/G/H/I/J/K/L 1-456 [» ]
    4ATQ X-ray 2.75 A/B/C/D/E/F/G/H/I/J/K/L 1-456 [» ]
    ProteinModelPortali A1R958.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 290340.AAur_3069.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABM08874 ; ABM08874 ; AAur_3069 .
    GeneIDi 4640834.
    KEGGi aau:AAur_3069.
    PATRICi 20981634. VBIArtAur67810_3121.

    Phylogenomic databases

    eggNOGi COG0160.
    HOGENOMi HOG000020206.
    KOi K07250.
    OMAi NSFTHTA.
    OrthoDBi EOG6QVRHN.

    Enzyme and pathway databases

    BioCyci AAUR290340:GI59-3068-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    InterProi IPR004632. 4NH2But_aminotransferase_bac.
    IPR005814. Aminotrans_3.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    PANTHERi PTHR11986. PTHR11986. 1 hit.
    Pfami PF00202. Aminotran_3. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
    SUPFAMi SSF53383. SSF53383. 1 hit.
    TIGRFAMsi TIGR00700. GABAtrnsam. 1 hit.
    PROSITEi PS00600. AA_TRANSFER_CLASS_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: TC1Imported.
    2. "Structures of a ?-aminobutyrate (GABA) transaminase from the s-triazine-degrading organism Arthrobacter aurescens TC1 in complex with PLP and with its external aldimine PLP-GABA adduct."
      Bruce H., Nguyen Tuan A., Mangas Sanchez J., Leese C., Hopwood J., Hyde R., Hart S., Turkenburg J.P., Grogan G.
      Acta Crystallogr. F 68:1175-1180(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.75 ANGSTROMS) IN COMPLEX WITH N6-(PYRIDOXALPHOSPHATE)LYSINE.

    Entry informationi

    Entry nameiA1R958_ARTAT
    AccessioniPrimary (citable) accession number: A1R958
    Entry historyi
    Integrated into UniProtKB/TrEMBL: February 6, 2007
    Last sequence update: February 6, 2007
    Last modified: October 1, 2014
    This is version 54 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported, Complete proteome, Reference proteomeImported

    External Data

    Dasty 3