A1R8P8 (COAA_ARTAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Pantothenate kinase
EC=2.7.1.33

Alternative name(s):
Pantothenic acid kinase

Gene names

Name:	coaA
Ordered Locus Names:	AAur_2901

Organism

Arthrobacter aurescens (strain TC1) [Complete proteome] [HAMAP]

Taxonomic identifier

290340 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micrococcineae › Micrococcaceae › Arthrobacter

Protein attributes

Sequence length	323 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + (R)-pantothenate = ADP + (R)-4'-phosphopantothenate. HAMAP MF_00215
Pathway	Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5. HAMAP MF_00215
Subcellular location	Cytoplasm Probable HAMAP MF_00215.
Sequence similarities	Belongs to the prokaryotic pantothenate kinase family.

Ontologies

Keywords
Biological process	Coenzyme A biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	coenzyme A biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW pantothenate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 323	323	Pantothenate kinase HAMAP MF_00215		PRO_0000325542
Regions
	Nucleotide binding	101 – 108	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	A1R8P8 [UniParc]. Last modified February 6, 2007. Version 1. Checksum: 2E42FB1C30D027FF	FASTA	323	36,971
	10 20 30 40 50 60 MSVTLQRTEA NGDGASPFVE LDRQTWSRLA AQMEQPLNEE DIFRLRGLGD PLDMKEVREV 70 80 90 100 110 120 YLPLSRLLHL YVEASHQLHA ATTTFLGEQT QRTPFVIGVA GSVAVGKSTI ARVLREMLRR 130 140 150 160 170 180 WPGTPNVELI TTDGFLYPLA ELKRRHLLER KGFPESYDRR GLLRFVSEVK GGAEEVRAPW 190 200 210 220 230 240 YSHVTYDIVP GKEVVVRRPD VLIVEGLNVL APARPRMDGK QGLAVSDFFD FSIYVDAKTS 250 260 270 280 290 300 YIEEWYVDRF RKLRTTAFAQ PESYFHRYAT LSDDDAESTA RGIWKRINEP NLEENVLPTR 310 320 GRAQLVLTKD ADHSIRRMLL RKV

References

[1]

"Secrets of soil survival revealed by the genome sequence of Arthrobacter aurescens TC1." Mongodin E.F., Shapir N., Daugherty S.C., DeBoy R.T., Emerson J.B., Shvartzbeyn A., Radune D., Vamathevan J., Riggs F., Grinberg V., Khouri H.M., Wackett L.P., Nelson K.E., Sadowsky M.J. PLoS Genet. 2:2094-2106(2006) [PubMed: 17194220] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: TC1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000474 Genomic DNA. Translation: ABM10005.1.
RefSeq	YP_948610.1. NC_008711.1.
3D structure databases
ProteinModelPortal	A1R8P8.
SMR	A1R8P8. Positions 16-323.
ModBase	Search...
Protein-protein interaction databases
STRING	A1R8P8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4640569.
GenomeReviews	Gene locus AAur_2901 in contig CP000474_GR.
KEGG	aau:AAur_2901.
PATRIC	20981282. VBIArtAur67810_2949.
TIGR	AAur_2901.
Phylogenomic databases
eggNOG	COG1072.
HOGENOM	HBG732538.
OMA	EVYLPLS.
ProtClustDB	PRK05439.
Enzyme and pathway databases
BioCyc	AAUR290340:AAUR_2901-MONOMER.
Family and domain databases
HAMAP	MF_00215. Pantothen_kinase_1. [Tree]
InterPro	IPR004566. PanK_bact. IPR006083. PRK/URK. [Graphical view]
KO	K00867.
PANTHER	PTHR10285:SF7. PanK_bact. 1 hit.
Pfam	PF00485. PRK. 1 hit. [Graphical view]
PIRSF	PIRSF000545. Pantothenate_kin. 1 hit.
TIGRFAMs	TIGR00554. PanK_bact. 1 hit.
ProtoNet	Search...

Entry information

Entry name

COAA_ARTAT

Accession

Primary (citable) accession number: A1R8P8

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 18, 2008
Last sequence update:	February 6, 2007
Last modified:	December 14, 2011
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program